Preliminary study on brain resting-state networks and cognitive impairments of patients with obstructive sleep apnea–hypopnea syndrome
Abstract Background To investigate functional changes in brain resting-state networks (RSNs) in patients with obstructive sleep apnea–hypopnea syndrome (OSAHS) and their correlations with sleep breathing disorders and neurocognitive performance. Methods In this study, 18 OSAHS patients and 18 matche...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12883-022-02991-w |
| _version_ | 1811302372800987136 |
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| author | Yaqing He Junkang Shen Xiang Wang Qiaozhen Wu Jiacheng Liu Yiding Ji |
| author_facet | Yaqing He Junkang Shen Xiang Wang Qiaozhen Wu Jiacheng Liu Yiding Ji |
| author_sort | Yaqing He |
| collection | DOAJ |
| description | Abstract Background To investigate functional changes in brain resting-state networks (RSNs) in patients with obstructive sleep apnea–hypopnea syndrome (OSAHS) and their correlations with sleep breathing disorders and neurocognitive performance. Methods In this study, 18 OSAHS patients and 18 matched healthy controls underwent neurocognitive assessment and magnetic resonance imaging (MRI). Group-level independent component analysis (ICA) and statistical analyses were used to explore between-group differences in RSNs and the relationship between functional changes in RSNs, sleep breathing disorders and neurocognitive performance. Results The OSAHS patients performed worse on neuropsychological tests than the healthy controls. Eight RSNs were identified, and between-group analyses showed that OSAHS patients displayed significantly decreased functional connectivity in the bilateral posterior cingulate gyri (PCC) within the default mode network (DMN), the right middle frontal gyrus (MFG) within the dorsal attention network (DAN), and the left superior temporal gyrus (STG) within the ventral attention network (VAN), and increased functional connectivity in the right superior frontal gyrus (SFG) within the salience network (SN). Further correlation analyses revealed that the average ICA z-scores in the bilateral PCC were correlated with sleep breathing disorders. Conclusions Our findings demonstrate that the DMN, SN, DAN, and VAN are impaired during the resting state and are associated with decreased functionally distinct aspects of cognition in patients with OSAHS. Moreover, the intermittent hypoxia and sleep fragmentation caused by OSAHS are likely to be the main influencing factors. |
| first_indexed | 2024-04-13T07:27:04Z |
| format | Article |
| id | doaj.art-7da683ad50d44420bbb86f3805ff5c81 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-13T07:27:04Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-7da683ad50d44420bbb86f3805ff5c812022-12-22T02:56:27ZengBMCBMC Neurology1471-23772022-12-012211910.1186/s12883-022-02991-wPreliminary study on brain resting-state networks and cognitive impairments of patients with obstructive sleep apnea–hypopnea syndromeYaqing He0Junkang Shen1Xiang Wang2Qiaozhen Wu3Jiacheng Liu4Yiding Ji5Department of Radiology, Suzhou Ninth People’s HospitalDepartment of Radiology, The Second Affiliated Hospital of Soochow UniversityDepartment of Respiratory, Suzhou Ninth People’s HospitalDepartment of Respiratory, Suzhou Ninth People’s HospitalDepartment of Radiology, The Affiliated Zhongda Hospital of Southeast University Medical SchoolDepartment of Radiology, Suzhou Ninth People’s HospitalAbstract Background To investigate functional changes in brain resting-state networks (RSNs) in patients with obstructive sleep apnea–hypopnea syndrome (OSAHS) and their correlations with sleep breathing disorders and neurocognitive performance. Methods In this study, 18 OSAHS patients and 18 matched healthy controls underwent neurocognitive assessment and magnetic resonance imaging (MRI). Group-level independent component analysis (ICA) and statistical analyses were used to explore between-group differences in RSNs and the relationship between functional changes in RSNs, sleep breathing disorders and neurocognitive performance. Results The OSAHS patients performed worse on neuropsychological tests than the healthy controls. Eight RSNs were identified, and between-group analyses showed that OSAHS patients displayed significantly decreased functional connectivity in the bilateral posterior cingulate gyri (PCC) within the default mode network (DMN), the right middle frontal gyrus (MFG) within the dorsal attention network (DAN), and the left superior temporal gyrus (STG) within the ventral attention network (VAN), and increased functional connectivity in the right superior frontal gyrus (SFG) within the salience network (SN). Further correlation analyses revealed that the average ICA z-scores in the bilateral PCC were correlated with sleep breathing disorders. Conclusions Our findings demonstrate that the DMN, SN, DAN, and VAN are impaired during the resting state and are associated with decreased functionally distinct aspects of cognition in patients with OSAHS. Moreover, the intermittent hypoxia and sleep fragmentation caused by OSAHS are likely to be the main influencing factors.https://doi.org/10.1186/s12883-022-02991-wObstructive sleep apneaCognitive impairmentResting-state networksIndependent component analysis |
| spellingShingle | Yaqing He Junkang Shen Xiang Wang Qiaozhen Wu Jiacheng Liu Yiding Ji Preliminary study on brain resting-state networks and cognitive impairments of patients with obstructive sleep apnea–hypopnea syndrome BMC Neurology Obstructive sleep apnea Cognitive impairment Resting-state networks Independent component analysis |
| title | Preliminary study on brain resting-state networks and cognitive impairments of patients with obstructive sleep apnea–hypopnea syndrome |
| title_full | Preliminary study on brain resting-state networks and cognitive impairments of patients with obstructive sleep apnea–hypopnea syndrome |
| title_fullStr | Preliminary study on brain resting-state networks and cognitive impairments of patients with obstructive sleep apnea–hypopnea syndrome |
| title_full_unstemmed | Preliminary study on brain resting-state networks and cognitive impairments of patients with obstructive sleep apnea–hypopnea syndrome |
| title_short | Preliminary study on brain resting-state networks and cognitive impairments of patients with obstructive sleep apnea–hypopnea syndrome |
| title_sort | preliminary study on brain resting state networks and cognitive impairments of patients with obstructive sleep apnea hypopnea syndrome |
| topic | Obstructive sleep apnea Cognitive impairment Resting-state networks Independent component analysis |
| url | https://doi.org/10.1186/s12883-022-02991-w |
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