Associations of blood pressure components with risks of cardiovascular events and all‐cause death in a Chinese population: A Prospective Study
Abstract The associations of blood pressure components with cardiovascular risks and death remain unclear, and the definition of wide pulse pressure (PP) is still controversial. Using data from 1257 participants without a history of cardiovascular disease, who were followed for 4.84 years, we perfor...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-07-01
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| Series: | The Journal of Clinical Hypertension |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jch.14529 |
| _version_ | 1797645238467035136 |
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| author | Zhongying Zhang Xiang Gu Zhe Tang Shaochen Guan Hongjun Liu Xiaoguang Wu Yan Zhao Xianghua Fang |
| author_facet | Zhongying Zhang Xiang Gu Zhe Tang Shaochen Guan Hongjun Liu Xiaoguang Wu Yan Zhao Xianghua Fang |
| author_sort | Zhongying Zhang |
| collection | DOAJ |
| description | Abstract The associations of blood pressure components with cardiovascular risks and death remain unclear, and the definition of wide pulse pressure (PP) is still controversial. Using data from 1257 participants without a history of cardiovascular disease, who were followed for 4.84 years, we performed multivariable Cox regression analyses to assess how systolic blood pressure (SBP), diastolic blood pressure (DBP), and PP contribute to risks of cardiovascular events and all‐cause death. Among all participants, SBP and PP were significantly associated with the risks of cardiovascular events and all‐cause death (all p < .05). DBP was not significantly associated with the risk of all‐cause death; rather, it was only associated with a marginally significant 1% increased risk for cardiovascular events (p = 0.051). In participants aged < 65 years, DBP was significantly associated with a 3% increased risk for cardiovascular events (hazard ratio [HR]: 1.03, 95% confidence interval [95% CI]: 1.01–1.06). The association between PP and cardiovascular events appeared to be J‐shaped in comparison to participants with the lowest‐risk PP (50–60 mmHg), with adjusted HRs of 1.71 (95% CI: 1.03–2.85), 1.63 (95% CI: 1.00–2.68), and 2.13 (95% CI: 1.32–3.43) in the <50, 60.0–72.5, and ≥72.5 mmHg subgroups, respectively. The optimal cutoff points of a wide PP for predicting the risks of cardiovascular events and all‐cause death were 70.25 and 76.25 mmHg, respectively. SBP and PP had a greater effect on cardiovascular risk, whereas DBP independently influenced cardiovascular events in middle‐aged participants. Considerable PP alterations should be avoided in antihypertensive treatment. |
| first_indexed | 2024-03-11T14:43:27Z |
| format | Article |
| id | doaj.art-7da8c0f6650647d19723601d6c194efc |
| institution | Directory Open Access Journal |
| issn | 1524-6175 1751-7176 |
| language | English |
| last_indexed | 2024-03-11T14:43:27Z |
| publishDate | 2022-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj.art-7da8c0f6650647d19723601d6c194efc2023-10-30T13:26:30ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762022-07-0124782583710.1111/jch.14529Associations of blood pressure components with risks of cardiovascular events and all‐cause death in a Chinese population: A Prospective StudyZhongying Zhang0Xiang Gu1Zhe Tang2Shaochen Guan3Hongjun Liu4Xiaoguang Wu5Yan Zhao6Xianghua Fang7Geriatric department Xuanwu Hospital Capital Medical University Beijing ChinaMedical affair department Beijing Friendship Hospital, Capital Medical University Beijing ChinaBeijing Geriatric Healthcare Center Xuanwu Hospital Capital Medical University Beijing ChinaEvidence‐based Medical Center Xuanwu Hospital Capital Medical University Beijing ChinaEvidence‐based Medical Center Xuanwu Hospital Capital Medical University Beijing ChinaEvidence‐based Medical Center Xuanwu Hospital Capital Medical University Beijing ChinaEducation department Xuanwu Hospital Capital Medical University Beijing ChinaEvidence‐based Medical Center Xuanwu Hospital Capital Medical University Beijing ChinaAbstract The associations of blood pressure components with cardiovascular risks and death remain unclear, and the definition of wide pulse pressure (PP) is still controversial. Using data from 1257 participants without a history of cardiovascular disease, who were followed for 4.84 years, we performed multivariable Cox regression analyses to assess how systolic blood pressure (SBP), diastolic blood pressure (DBP), and PP contribute to risks of cardiovascular events and all‐cause death. Among all participants, SBP and PP were significantly associated with the risks of cardiovascular events and all‐cause death (all p < .05). DBP was not significantly associated with the risk of all‐cause death; rather, it was only associated with a marginally significant 1% increased risk for cardiovascular events (p = 0.051). In participants aged < 65 years, DBP was significantly associated with a 3% increased risk for cardiovascular events (hazard ratio [HR]: 1.03, 95% confidence interval [95% CI]: 1.01–1.06). The association between PP and cardiovascular events appeared to be J‐shaped in comparison to participants with the lowest‐risk PP (50–60 mmHg), with adjusted HRs of 1.71 (95% CI: 1.03–2.85), 1.63 (95% CI: 1.00–2.68), and 2.13 (95% CI: 1.32–3.43) in the <50, 60.0–72.5, and ≥72.5 mmHg subgroups, respectively. The optimal cutoff points of a wide PP for predicting the risks of cardiovascular events and all‐cause death were 70.25 and 76.25 mmHg, respectively. SBP and PP had a greater effect on cardiovascular risk, whereas DBP independently influenced cardiovascular events in middle‐aged participants. Considerable PP alterations should be avoided in antihypertensive treatment.https://doi.org/10.1111/jch.14529cardiovascular eventscohort studyhypertensionpulse pressure |
| spellingShingle | Zhongying Zhang Xiang Gu Zhe Tang Shaochen Guan Hongjun Liu Xiaoguang Wu Yan Zhao Xianghua Fang Associations of blood pressure components with risks of cardiovascular events and all‐cause death in a Chinese population: A Prospective Study The Journal of Clinical Hypertension cardiovascular events cohort study hypertension pulse pressure |
| title | Associations of blood pressure components with risks of cardiovascular events and all‐cause death in a Chinese population: A Prospective Study |
| title_full | Associations of blood pressure components with risks of cardiovascular events and all‐cause death in a Chinese population: A Prospective Study |
| title_fullStr | Associations of blood pressure components with risks of cardiovascular events and all‐cause death in a Chinese population: A Prospective Study |
| title_full_unstemmed | Associations of blood pressure components with risks of cardiovascular events and all‐cause death in a Chinese population: A Prospective Study |
| title_short | Associations of blood pressure components with risks of cardiovascular events and all‐cause death in a Chinese population: A Prospective Study |
| title_sort | associations of blood pressure components with risks of cardiovascular events and all cause death in a chinese population a prospective study |
| topic | cardiovascular events cohort study hypertension pulse pressure |
| url | https://doi.org/10.1111/jch.14529 |
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