Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor
Identification of inhibitors can be accelerated by using the target as a template for ligand formation. Here the authors show that DNA-functionalised magnetic nanoparticles guide templating of G-quadruplex bindingc-MYCinhibitors from an array of building blocks, and can be isolated by magnetic decan...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms16103 |
| _version_ | 1818990867876151296 |
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| author | Deepanjan Panda Puja Saha Tania Das Jyotirmayee Dash |
| author_facet | Deepanjan Panda Puja Saha Tania Das Jyotirmayee Dash |
| author_sort | Deepanjan Panda |
| collection | DOAJ |
| description | Identification of inhibitors can be accelerated by using the target as a template for ligand formation. Here the authors show that DNA-functionalised magnetic nanoparticles guide templating of G-quadruplex bindingc-MYCinhibitors from an array of building blocks, and can be isolated by magnetic decanting. |
| first_indexed | 2024-12-20T20:01:12Z |
| format | Article |
| id | doaj.art-7da98346636d440491fe4fd673780c1d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:01:12Z |
| publishDate | 2017-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7da98346636d440491fe4fd673780c1d2022-12-21T19:28:03ZengNature PortfolioNature Communications2041-17232017-07-018111110.1038/ncomms16103Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitorDeepanjan Panda0Puja Saha1Tania Das2Jyotirmayee Dash3Department of Organic Chemistry, Indian Association for the Cultivation of ScienceDepartment of Organic Chemistry, Indian Association for the Cultivation of ScienceDepartment of Organic Chemistry, Indian Association for the Cultivation of ScienceDepartment of Organic Chemistry, Indian Association for the Cultivation of ScienceIdentification of inhibitors can be accelerated by using the target as a template for ligand formation. Here the authors show that DNA-functionalised magnetic nanoparticles guide templating of G-quadruplex bindingc-MYCinhibitors from an array of building blocks, and can be isolated by magnetic decanting.https://doi.org/10.1038/ncomms16103 |
| spellingShingle | Deepanjan Panda Puja Saha Tania Das Jyotirmayee Dash Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor Nature Communications |
| title | Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor |
| title_full | Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor |
| title_fullStr | Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor |
| title_full_unstemmed | Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor |
| title_short | Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor |
| title_sort | target guided synthesis using dna nano templates for selectively assembling a g quadruplex binding c myc inhibitor |
| url | https://doi.org/10.1038/ncomms16103 |
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