The mutant of rs2075604 in STK11 improves HDL-c levels among newly diagnosed type 2 diabetes mellitus patients
Context: Type 2 diabetes mellitus (T2DM) patients tend to have lipid abnormalities, thus elevating the risk of complications and mortality. Early detection using a genomic approach could help identify the abnormality of lipid profiles so that it could reduce those burdens. A previous study found a h...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
GarVal Editorial Ltda.
2023-03-01
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| Series: | Journal of Pharmacy & Pharmacognosy Research |
| Subjects: | |
| Online Access: | https://jppres.com/jppres/pdf/vol11/jppres22.1541_11.2.255.pdf |
| _version_ | 1827953827140075520 |
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| author | Dita Maria Virginia Christine Patramurti Phebe Hendra Paulina Nadya Feranti Pebby Lorenza Faustina Evania Ngai Novita Anastasia Matea Nirmala Defi Mae Sri Hartati Wahyuningsih Dwi Aris Agung Nugrahaningsih |
| author_facet | Dita Maria Virginia Christine Patramurti Phebe Hendra Paulina Nadya Feranti Pebby Lorenza Faustina Evania Ngai Novita Anastasia Matea Nirmala Defi Mae Sri Hartati Wahyuningsih Dwi Aris Agung Nugrahaningsih |
| author_sort | Dita Maria Virginia |
| collection | DOAJ |
| description | Context: Type 2 diabetes mellitus (T2DM) patients tend to have lipid abnormalities, thus elevating the risk of complications and mortality. Early detection using a genomic approach could help identify the abnormality of lipid profiles so that it could reduce those burdens. A previous study found a high frequency of mutants in the rs2075604 as the intron area in the STK11 gene.
Aims: To analyze the effect of rs2075604 related to lipid abnormalities in newly diagnosed T2DM patients.
Methods: This present study conducted a cross-sectional study in the ten public healthcare facilities in Sleman, Yogyakarta. The genetic variants were detected using PCR-RFLP methods. A total of 130 patients who had to consume antidiabetic oral for three months participated in this study.
Results: This study revealed that the mutant variant dominated in this population at 61.5%. Mutant genotype, mutant allele, and dominant model reduce the risk of low HDL (OR = 0.33, 95% CI = 0.11-0.99; OR = 0.46, 95% CI = 0.24-0.90; OR = 0.33, 95% CI = 0.12-0.96; respectively). The improvement of low HDL risk by the mutant allele was confirmed through an adjusted model (OR = 0.47, 95% CI = 0.23-0.98). The mutant allele only influenced high LDL risk in the non-adjusted model (OR = 2.22, 95% CI = 1.02-4.82), but it did not found in other models.
Conclusions: The mutant of rs2075604 has a protective role in low HDL-c risk in Indonesia. However, further study is required to observe the effect on LDL-c. |
| first_indexed | 2024-04-09T14:19:38Z |
| format | Article |
| id | doaj.art-7dac61a95d0843238d78bed2f1a3f1be |
| institution | Directory Open Access Journal |
| issn | 0719-4250 |
| language | English |
| last_indexed | 2024-04-09T14:19:38Z |
| publishDate | 2023-03-01 |
| publisher | GarVal Editorial Ltda. |
| record_format | Article |
| series | Journal of Pharmacy & Pharmacognosy Research |
| spelling | doaj.art-7dac61a95d0843238d78bed2f1a3f1be2023-05-05T01:45:31ZengGarVal Editorial Ltda.Journal of Pharmacy & Pharmacognosy Research0719-42502023-03-0111225526210.56499/jppres22.1541_11.2.255The mutant of rs2075604 in STK11 improves HDL-c levels among newly diagnosed type 2 diabetes mellitus patientsDita Maria Virginia0https://orcid.org/0000-0003-0469-1913Christine Patramurti1https://orcid.org/0000-0002-2423-9695Phebe Hendra2https://orcid.org/0000-0002-1077-7847Paulina Nadya Feranti Pebby Lorenza3Faustina Evania Ngai4Novita Anastasia5Matea Nirmala Defi6Mae Sri Hartati Wahyuningsih7https://orcid.org/0000-0002-9274-5573Dwi Aris Agung Nugrahaningsih8https://orcid.org/0000-0002-1616-3053Faculty of Pharmacy, Sanata Dharma University, DI Yogyakarta, Indonesia.Faculty of Pharmacy, Sanata Dharma University, DI Yogyakarta, Indonesia.Faculty of Pharmacy, Sanata Dharma University, DI Yogyakarta, Indonesia.Faculty of Pharmacy, Sanata Dharma University, DI Yogyakarta, Indonesia.Faculty of Pharmacy, Sanata Dharma University, DI Yogyakarta, Indonesia.Faculty of Pharmacy, Sanata Dharma University, DI Yogyakarta, Indonesia.Faculty of Pharmacy, Sanata Dharma University, DI Yogyakarta, Indonesia.Department of Pharmacology and Therapy, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, DI Yogyakarta, Indonesia.Department of Pharmacology and Therapy, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, DI Yogyakarta, Indonesia. Center of Genetic Study, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, DI Yogyakarta, Indonesia.Context: Type 2 diabetes mellitus (T2DM) patients tend to have lipid abnormalities, thus elevating the risk of complications and mortality. Early detection using a genomic approach could help identify the abnormality of lipid profiles so that it could reduce those burdens. A previous study found a high frequency of mutants in the rs2075604 as the intron area in the STK11 gene. Aims: To analyze the effect of rs2075604 related to lipid abnormalities in newly diagnosed T2DM patients. Methods: This present study conducted a cross-sectional study in the ten public healthcare facilities in Sleman, Yogyakarta. The genetic variants were detected using PCR-RFLP methods. A total of 130 patients who had to consume antidiabetic oral for three months participated in this study. Results: This study revealed that the mutant variant dominated in this population at 61.5%. Mutant genotype, mutant allele, and dominant model reduce the risk of low HDL (OR = 0.33, 95% CI = 0.11-0.99; OR = 0.46, 95% CI = 0.24-0.90; OR = 0.33, 95% CI = 0.12-0.96; respectively). The improvement of low HDL risk by the mutant allele was confirmed through an adjusted model (OR = 0.47, 95% CI = 0.23-0.98). The mutant allele only influenced high LDL risk in the non-adjusted model (OR = 2.22, 95% CI = 1.02-4.82), but it did not found in other models. Conclusions: The mutant of rs2075604 has a protective role in low HDL-c risk in Indonesia. However, further study is required to observe the effect on LDL-c.https://jppres.com/jppres/pdf/vol11/jppres22.1541_11.2.255.pdfrs2075604stk11lipid profilestype 2 diabetes mellitus |
| spellingShingle | Dita Maria Virginia Christine Patramurti Phebe Hendra Paulina Nadya Feranti Pebby Lorenza Faustina Evania Ngai Novita Anastasia Matea Nirmala Defi Mae Sri Hartati Wahyuningsih Dwi Aris Agung Nugrahaningsih The mutant of rs2075604 in STK11 improves HDL-c levels among newly diagnosed type 2 diabetes mellitus patients Journal of Pharmacy & Pharmacognosy Research rs2075604 stk11 lipid profiles type 2 diabetes mellitus |
| title | The mutant of rs2075604 in STK11 improves HDL-c levels among newly diagnosed type 2 diabetes mellitus patients |
| title_full | The mutant of rs2075604 in STK11 improves HDL-c levels among newly diagnosed type 2 diabetes mellitus patients |
| title_fullStr | The mutant of rs2075604 in STK11 improves HDL-c levels among newly diagnosed type 2 diabetes mellitus patients |
| title_full_unstemmed | The mutant of rs2075604 in STK11 improves HDL-c levels among newly diagnosed type 2 diabetes mellitus patients |
| title_short | The mutant of rs2075604 in STK11 improves HDL-c levels among newly diagnosed type 2 diabetes mellitus patients |
| title_sort | mutant of rs2075604 in stk11 improves hdl c levels among newly diagnosed type 2 diabetes mellitus patients |
| topic | rs2075604 stk11 lipid profiles type 2 diabetes mellitus |
| url | https://jppres.com/jppres/pdf/vol11/jppres22.1541_11.2.255.pdf |
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