The causal relationship between O2:K7:H6 extra-intestinal pathogenic Escherichia coli (ExPEC) and native valve endocarditis: a case report
Abstract Background Native valves infective endocarditis due to Escherichia coli is still a rare disease and a particular virulence of some E.coli isolate may be suspected. Case presentation A 79-year-old woman presented during the post-operative period of an orthopedic surgery a urinary tract infec...
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| Format: | Article |
| Language: | English |
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BMC
2021-04-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-021-06066-y |
| _version_ | 1819299013714771968 |
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| author | Marie-Françoise Leonard Hector Rodriguez-Villalobos Nadia Boisen Flemming Scheutz Pierre-François Laterre Philippe Hantson |
| author_facet | Marie-Françoise Leonard Hector Rodriguez-Villalobos Nadia Boisen Flemming Scheutz Pierre-François Laterre Philippe Hantson |
| author_sort | Marie-Françoise Leonard |
| collection | DOAJ |
| description | Abstract Background Native valves infective endocarditis due to Escherichia coli is still a rare disease and a particular virulence of some E.coli isolate may be suspected. Case presentation A 79-year-old woman presented during the post-operative period of an orthopedic surgery a urinary tract infection following obstructive ureteral lithiasis. E. coli was isolated from a pure culture of urine and blood sampled simultaneously. After evidence of sustained E.coli septicemia, further investigations revealed acute cholecystitis with the same micro-organism in biliary drainage and a native valve mitral endocarditis. E.coli was identified as O2:K7:H6, phylogenetic group B2, ST141, and presented several putative and proven virulence genes. The present isolate can be classified as both extra-intestinal pathogenic E.coli (ExPECJJ) and uropathogenic E. coli (UPECHM). Conclusions The relationship between the virulent factors present in ExPEC strains and some serotypes of E. coli that could facilitate the adherence to cardiac valves warrants further investigation. |
| first_indexed | 2024-12-24T05:39:03Z |
| format | Article |
| id | doaj.art-7dad87043a744bd6817c7747198c445c |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-24T05:39:03Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-7dad87043a744bd6817c7747198c445c2022-12-21T17:12:53ZengBMCBMC Infectious Diseases1471-23342021-04-012111410.1186/s12879-021-06066-yThe causal relationship between O2:K7:H6 extra-intestinal pathogenic Escherichia coli (ExPEC) and native valve endocarditis: a case reportMarie-Françoise Leonard0Hector Rodriguez-Villalobos1Nadia Boisen2Flemming Scheutz3Pierre-François Laterre4Philippe Hantson5Laboratoire SynlabDepartment of Microbiology, Cliniques universitaires St-Luc, Université catholique de LouvainDepartment of Bacteria, Parasites and Fungi, Statens Serum Institut, The International Centre for Reference and Research on Escherichia and KlebsiellaDepartment of Bacteria, Parasites and Fungi, Statens Serum Institut, The International Centre for Reference and Research on Escherichia and KlebsiellaDepartment of Intensive Care, Cliniques universitaires St-Luc, Université catholique de LouvainDepartment of Intensive Care, Cliniques universitaires St-Luc, Université catholique de LouvainAbstract Background Native valves infective endocarditis due to Escherichia coli is still a rare disease and a particular virulence of some E.coli isolate may be suspected. Case presentation A 79-year-old woman presented during the post-operative period of an orthopedic surgery a urinary tract infection following obstructive ureteral lithiasis. E. coli was isolated from a pure culture of urine and blood sampled simultaneously. After evidence of sustained E.coli septicemia, further investigations revealed acute cholecystitis with the same micro-organism in biliary drainage and a native valve mitral endocarditis. E.coli was identified as O2:K7:H6, phylogenetic group B2, ST141, and presented several putative and proven virulence genes. The present isolate can be classified as both extra-intestinal pathogenic E.coli (ExPECJJ) and uropathogenic E. coli (UPECHM). Conclusions The relationship between the virulent factors present in ExPEC strains and some serotypes of E. coli that could facilitate the adherence to cardiac valves warrants further investigation.https://doi.org/10.1186/s12879-021-06066-yNative mitral valveEndocarditisEscherichia coliUrinary tract infection - virulence factorsCase report |
| spellingShingle | Marie-Françoise Leonard Hector Rodriguez-Villalobos Nadia Boisen Flemming Scheutz Pierre-François Laterre Philippe Hantson The causal relationship between O2:K7:H6 extra-intestinal pathogenic Escherichia coli (ExPEC) and native valve endocarditis: a case report BMC Infectious Diseases Native mitral valve Endocarditis Escherichia coli Urinary tract infection - virulence factors Case report |
| title | The causal relationship between O2:K7:H6 extra-intestinal pathogenic Escherichia coli (ExPEC) and native valve endocarditis: a case report |
| title_full | The causal relationship between O2:K7:H6 extra-intestinal pathogenic Escherichia coli (ExPEC) and native valve endocarditis: a case report |
| title_fullStr | The causal relationship between O2:K7:H6 extra-intestinal pathogenic Escherichia coli (ExPEC) and native valve endocarditis: a case report |
| title_full_unstemmed | The causal relationship between O2:K7:H6 extra-intestinal pathogenic Escherichia coli (ExPEC) and native valve endocarditis: a case report |
| title_short | The causal relationship between O2:K7:H6 extra-intestinal pathogenic Escherichia coli (ExPEC) and native valve endocarditis: a case report |
| title_sort | causal relationship between o2 k7 h6 extra intestinal pathogenic escherichia coli expec and native valve endocarditis a case report |
| topic | Native mitral valve Endocarditis Escherichia coli Urinary tract infection - virulence factors Case report |
| url | https://doi.org/10.1186/s12879-021-06066-y |
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