Association between serum total bilirubin and diabetic kidney disease in US diabetic patients
BackgroundBilirubin has been widely reported to be a protective factor against diabetic kidney disease (DKD) in Asian populations. However, few large-sample analyses have been conducted in American populations. This study aimed to investigate the association between serum total bilirubin (STB) level...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1310003/full |
| _version_ | 1797392402047041536 |
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| author | Jian-Min Lv Xiu-E Shi Qiong Ma Nan Chen Mi Fu Jian-Zheng Liu Qiao-Rong Fan |
| author_facet | Jian-Min Lv Xiu-E Shi Qiong Ma Nan Chen Mi Fu Jian-Zheng Liu Qiao-Rong Fan |
| author_sort | Jian-Min Lv |
| collection | DOAJ |
| description | BackgroundBilirubin has been widely reported to be a protective factor against diabetic kidney disease (DKD) in Asian populations. However, few large-sample analyses have been conducted in American populations. This study aimed to investigate the association between serum total bilirubin (STB) level and DKD in a US diabetic cohort.MethodsThis cross-sectional study enrolled participants from the National Health and Nutrition Examination Survey (NHANES) 2003–2018. Univariate and multivariate logistic regression analyses were performed to assess the association between STB level and DKD. Three models were conducted to control the potential confounding factors. Subgroup analysis was carried out for further validation.ResultsAmong the 5,355 participants, the median age [interquartile range (IQR)] was 62 [52–71] years; 2,836 (52.96%) were male, and 1,576 (29.43%) were diagnosed with DKD. In the entire cohort, no significant association between STB level and DKD was observed in any logistic regression models (p > 0.05). Subgroup analysis revealed that, in U.S. diabetic males, STB levels > 11.98 µmol/L were associated with a nearly 30% lower risk of DKD than STB levels ≤ 8.55 µmol/L. Additionally, a moderate STB level (8.56–11.98 μmol/L) was found associated with a nearly 25% lower risk of DKD in U.S. diabetic patients over 65 years old.ConclusionThe association of STB level with DKD may depict differences across diverse populations, among which the impact of race, sex, and age requires thorough consideration and relevant inferences should be interpreted cautiously. |
| first_indexed | 2024-03-08T23:47:42Z |
| format | Article |
| id | doaj.art-7dae2c557fa649d89a674067bfd774fb |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T23:47:42Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-7dae2c557fa649d89a674067bfd774fb2023-12-13T15:49:31ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-12-011410.3389/fendo.2023.13100031310003Association between serum total bilirubin and diabetic kidney disease in US diabetic patientsJian-Min Lv0Xiu-E Shi1Qiong Ma2Nan Chen3Mi Fu4Jian-Zheng Liu5Qiao-Rong Fan6Rehabilitation Science Institute, Shaanxi Provincial Rehabilitation Hospital, Xi’an, Shaanxi, ChinaRehabilitation Science Institute, Shaanxi Provincial Rehabilitation Hospital, Xi’an, Shaanxi, ChinaHealth Department, Northwest Women’s and Children’s Hospital & Shaanxi Provincial Maternity and Child Healthcare Hospital, Xi’an, Shaanxi, ChinaRehabilitation Science Institute, Shaanxi Provincial Rehabilitation Hospital, Xi’an, Shaanxi, ChinaHealth Department, Northwest Women’s and Children’s Hospital & Shaanxi Provincial Maternity and Child Healthcare Hospital, Xi’an, Shaanxi, ChinaDepartment of Cardiology, Xijing Hospital, Xi’an, Shaanxi, ChinaDepartment of Primary health care, Baoji Maternal And Child Health Hospital, Bao Ji, Shaanxi, ChinaBackgroundBilirubin has been widely reported to be a protective factor against diabetic kidney disease (DKD) in Asian populations. However, few large-sample analyses have been conducted in American populations. This study aimed to investigate the association between serum total bilirubin (STB) level and DKD in a US diabetic cohort.MethodsThis cross-sectional study enrolled participants from the National Health and Nutrition Examination Survey (NHANES) 2003–2018. Univariate and multivariate logistic regression analyses were performed to assess the association between STB level and DKD. Three models were conducted to control the potential confounding factors. Subgroup analysis was carried out for further validation.ResultsAmong the 5,355 participants, the median age [interquartile range (IQR)] was 62 [52–71] years; 2,836 (52.96%) were male, and 1,576 (29.43%) were diagnosed with DKD. In the entire cohort, no significant association between STB level and DKD was observed in any logistic regression models (p > 0.05). Subgroup analysis revealed that, in U.S. diabetic males, STB levels > 11.98 µmol/L were associated with a nearly 30% lower risk of DKD than STB levels ≤ 8.55 µmol/L. Additionally, a moderate STB level (8.56–11.98 μmol/L) was found associated with a nearly 25% lower risk of DKD in U.S. diabetic patients over 65 years old.ConclusionThe association of STB level with DKD may depict differences across diverse populations, among which the impact of race, sex, and age requires thorough consideration and relevant inferences should be interpreted cautiously.https://www.frontiersin.org/articles/10.3389/fendo.2023.1310003/fulldiabetic kidney diseaseserum total bilirubincross-sectional studyNHANES (National Health and Nutrition Examination Survey)association |
| spellingShingle | Jian-Min Lv Xiu-E Shi Qiong Ma Nan Chen Mi Fu Jian-Zheng Liu Qiao-Rong Fan Association between serum total bilirubin and diabetic kidney disease in US diabetic patients Frontiers in Endocrinology diabetic kidney disease serum total bilirubin cross-sectional study NHANES (National Health and Nutrition Examination Survey) association |
| title | Association between serum total bilirubin and diabetic kidney disease in US diabetic patients |
| title_full | Association between serum total bilirubin and diabetic kidney disease in US diabetic patients |
| title_fullStr | Association between serum total bilirubin and diabetic kidney disease in US diabetic patients |
| title_full_unstemmed | Association between serum total bilirubin and diabetic kidney disease in US diabetic patients |
| title_short | Association between serum total bilirubin and diabetic kidney disease in US diabetic patients |
| title_sort | association between serum total bilirubin and diabetic kidney disease in us diabetic patients |
| topic | diabetic kidney disease serum total bilirubin cross-sectional study NHANES (National Health and Nutrition Examination Survey) association |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1310003/full |
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