| Summary: | Cardamine violifolia polysaccharide (CVP) has been studied mainly for structural analysis and in vitro activity. The present study showed that CVP supplementation was effective in enhancing the production of N-Oleoylethanolamin and improving the content of campesterol and stigmasterol in the Steroid biosynthesis - Mus musculus metabolic pathway. The genus levels of Ruminococcaceae_UCG-014 genus, Lactobacillus genus, were significantly increased in the intestine of mice after CVP infusion. Importantly, CVP had a protective effect on the intestinal microbiota of mice, which may result from the increase in short-chain fatty acid-producing bacteria of the genera Ruminococcaceae and Lactobacillus. The therapeutic effect of CVP in STZ-induced type 2 diabetic mice may be achieved by modulating the structure of the intestinal microbiota and regulating the Steroid biosynthesis - Mus musculus metabolic pathway, and CVP is expected to be a potential food for the treatment and prevention of type 2 diabetes.
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