Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy: Dynamic analysis on cytotoxic effects of LW-218

Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy: Dynamic analysis on cytotoxic effects of LW-218

The integrity of lysosomes is of vital importance to survival of tumor cells. We demonstrated that LW-218, a synthetic flavonoid, induced rapid lysosomal enlargement accompanied with lysosomal membrane permeabilization in hematological malignancy. LW-218-induced lysosomal damage and lysosome-depende...

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Bibliographic Details
Main Authors: Po Hu, Hui Li, Wenzhuo Sun, Hongzheng Wang, Xiaoxuan Yu, Yingjie Qing, Zhanyu Wang, Mengyuan Zhu, Jingyan Xu, Qinglong Guo, Hui Hui
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Acta Pharmaceutica Sinica B
Subjects:
LW-218
Lysosomal damage
Lysophagy
Lysosomal membrane permeabilization
Lysosome-dependent cell death
Cholesterol
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521000411

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