Ethyl 2-(3-Methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate
A simple route for synthesis of ethyl 2-(3-methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate is developed. The present work involves condensation of 2-(2-nitrobenzamido)propanoic acid with ethyl anthranillate followed by the H2/Pd/C reduction to give the amino ester which upon hea...
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-12-01
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| Series: | Molbank |
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| Online Access: | http://www.mdpi.com/1422-8599/2013/4/M811 |
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| author | Naim H. Al-Said Ayat M. Al-Sghair |
| author_facet | Naim H. Al-Said Ayat M. Al-Sghair |
| author_sort | Naim H. Al-Said |
| collection | DOAJ |
| description | A simple route for synthesis of ethyl 2-(3-methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate is developed. The present work involves condensation of 2-(2-nitrobenzamido)propanoic acid with ethyl anthranillate followed by the H2/Pd/C reduction to give the amino ester which upon heating in DMF in the presence of FeCl3 affords the title compound. The structure of the title compound was established on the basis of 1H-NMR, 13C-NMR and mass spectral data. |
| first_indexed | 2024-12-23T06:33:14Z |
| format | Article |
| id | doaj.art-7db806df7e2f488bbea4971e25ab3d2b |
| institution | Directory Open Access Journal |
| issn | 1422-8599 |
| language | English |
| last_indexed | 2024-12-23T06:33:14Z |
| publishDate | 2013-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molbank |
| spelling | doaj.art-7db806df7e2f488bbea4971e25ab3d2b2022-12-21T17:56:52ZengMDPI AGMolbank1422-85992013-12-0120134M81110.3390/M811M811Ethyl 2-(3-Methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoateNaim H. Al-Said0Ayat M. Al-Sghair1Department of Chemistry, Jordan University of Science and Technology, Irbid 22110, JordanDepartment of Chemistry, Jordan University of Science and Technology, Irbid 22110, JordanA simple route for synthesis of ethyl 2-(3-methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate is developed. The present work involves condensation of 2-(2-nitrobenzamido)propanoic acid with ethyl anthranillate followed by the H2/Pd/C reduction to give the amino ester which upon heating in DMF in the presence of FeCl3 affords the title compound. The structure of the title compound was established on the basis of 1H-NMR, 13C-NMR and mass spectral data.http://www.mdpi.com/1422-8599/2013/4/M811benzo[e][1,4]diazepineferric chloridecyclization |
| spellingShingle | Naim H. Al-Said Ayat M. Al-Sghair Ethyl 2-(3-Methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate Molbank benzo[e][1,4]diazepine ferric chloride cyclization |
| title | Ethyl 2-(3-Methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate |
| title_full | Ethyl 2-(3-Methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate |
| title_fullStr | Ethyl 2-(3-Methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate |
| title_full_unstemmed | Ethyl 2-(3-Methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate |
| title_short | Ethyl 2-(3-Methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate |
| title_sort | ethyl 2 3 methyl 5 oxo 4 5 dihydro 3h benzo e 1 4 diazepin 2 ylamino benzoate |
| topic | benzo[e][1,4]diazepine ferric chloride cyclization |
| url | http://www.mdpi.com/1422-8599/2013/4/M811 |
| work_keys_str_mv | AT naimhalsaid ethyl23methyl5oxo45dihydro3hbenzoe14diazepin2ylaminobenzoate AT ayatmalsghair ethyl23methyl5oxo45dihydro3hbenzoe14diazepin2ylaminobenzoate |