Recent Advances in the Synthesis of Pyrazole Derivatives: A Review
Pyrazole, characterized by a five-membered heterocyclic structure featuring two neighboring nitrogen atoms, serves as a core element. Pyrazoles hold a privileged status as versatile frameworks in various sectors of the chemical industry, including medicine and agriculture. Previous reviews have exte...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Reactions |
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| Online Access: | https://www.mdpi.com/2624-781X/4/3/29 |
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| author | Issam Ameziane El Hassani Khouloud Rouzi Hamza Assila Khalid Karrouchi M’hammed Ansar |
| author_facet | Issam Ameziane El Hassani Khouloud Rouzi Hamza Assila Khalid Karrouchi M’hammed Ansar |
| author_sort | Issam Ameziane El Hassani |
| collection | DOAJ |
| description | Pyrazole, characterized by a five-membered heterocyclic structure featuring two neighboring nitrogen atoms, serves as a core element. Pyrazoles hold a privileged status as versatile frameworks in various sectors of the chemical industry, including medicine and agriculture. Previous reviews have extensively highlighted the significance of pyrazoles and their diverse biological activities, encompassing roles such as antituberculosis, antimicrobial, antifungal, anti-inflammatory, anticancer, and antidiabetic agents. Consequently, they have garnered substantial interest from researchers. The aim of this review is to offer a comprehensive overview of the published research related to the synthesis of pyrazole derivatives, encompassing a discussion of diverse methods for accessing the pyrazole moiety. These methods span from utilizing transition-metal catalysts and photoredox reactions to employing one-pot multicomponent processes, novel reactants, and innovative reaction types. It encompasses studies conducted by numerous scientists worldwide, showcasing collective efforts in advancing the methodologies and applications of pyrazole derivatives. |
| first_indexed | 2024-03-10T22:07:27Z |
| format | Article |
| id | doaj.art-7db9f9bb22c2418d9894be73fe3ece6f |
| institution | Directory Open Access Journal |
| issn | 2624-781X |
| language | English |
| last_indexed | 2024-03-10T22:07:27Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Reactions |
| spelling | doaj.art-7db9f9bb22c2418d9894be73fe3ece6f2023-11-19T12:44:39ZengMDPI AGReactions2624-781X2023-09-014347850410.3390/reactions4030029Recent Advances in the Synthesis of Pyrazole Derivatives: A ReviewIssam Ameziane El Hassani0Khouloud Rouzi1Hamza Assila2Khalid Karrouchi3M’hammed Ansar4Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat 10100, MoroccoLaboratory of Analytical Chemistry and Bromatology, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat 10100, MoroccoLaboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat 10100, MoroccoLaboratory of Analytical Chemistry and Bromatology, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat 10100, MoroccoLaboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat 10100, MoroccoPyrazole, characterized by a five-membered heterocyclic structure featuring two neighboring nitrogen atoms, serves as a core element. Pyrazoles hold a privileged status as versatile frameworks in various sectors of the chemical industry, including medicine and agriculture. Previous reviews have extensively highlighted the significance of pyrazoles and their diverse biological activities, encompassing roles such as antituberculosis, antimicrobial, antifungal, anti-inflammatory, anticancer, and antidiabetic agents. Consequently, they have garnered substantial interest from researchers. The aim of this review is to offer a comprehensive overview of the published research related to the synthesis of pyrazole derivatives, encompassing a discussion of diverse methods for accessing the pyrazole moiety. These methods span from utilizing transition-metal catalysts and photoredox reactions to employing one-pot multicomponent processes, novel reactants, and innovative reaction types. It encompasses studies conducted by numerous scientists worldwide, showcasing collective efforts in advancing the methodologies and applications of pyrazole derivatives.https://www.mdpi.com/2624-781X/4/3/29pyrazole derivativessynthesisreactionsheterocyclicrecent advances |
| spellingShingle | Issam Ameziane El Hassani Khouloud Rouzi Hamza Assila Khalid Karrouchi M’hammed Ansar Recent Advances in the Synthesis of Pyrazole Derivatives: A Review Reactions pyrazole derivatives synthesis reactions heterocyclic recent advances |
| title | Recent Advances in the Synthesis of Pyrazole Derivatives: A Review |
| title_full | Recent Advances in the Synthesis of Pyrazole Derivatives: A Review |
| title_fullStr | Recent Advances in the Synthesis of Pyrazole Derivatives: A Review |
| title_full_unstemmed | Recent Advances in the Synthesis of Pyrazole Derivatives: A Review |
| title_short | Recent Advances in the Synthesis of Pyrazole Derivatives: A Review |
| title_sort | recent advances in the synthesis of pyrazole derivatives a review |
| topic | pyrazole derivatives synthesis reactions heterocyclic recent advances |
| url | https://www.mdpi.com/2624-781X/4/3/29 |
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