Cell-to-cell communication in bilateral macronodular adrenal hyperplasia causing hypercortisolism
It has been well established that, in the human adrenal gland, cortisol secretion is not only controlled by circulating corticotropin but is also influenced by a wide variety of bioactive signals, including conventional neurotransmitters and neuropeptides, released within the cortex by various cell...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00034/full |
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| author | Herve eLefebvre Herve eLefebvre Herve eLefebvre Celine eDuparc Celine eDuparc Gaetan ePrevost Gaetan ePrevost Gaetan ePrevost Jerome eBertherat Jerome eBertherat Estelle eLouiset Estelle eLouiset |
| author_facet | Herve eLefebvre Herve eLefebvre Herve eLefebvre Celine eDuparc Celine eDuparc Gaetan ePrevost Gaetan ePrevost Gaetan ePrevost Jerome eBertherat Jerome eBertherat Estelle eLouiset Estelle eLouiset |
| author_sort | Herve eLefebvre |
| collection | DOAJ |
| description | It has been well established that, in the human adrenal gland, cortisol secretion is not only controlled by circulating corticotropin but is also influenced by a wide variety of bioactive signals, including conventional neurotransmitters and neuropeptides, released within the cortex by various cell types such as chromaffin cells, neurons, cells of the immune system, adipocytes and endothelial cells. These different types of cells are present in bilateral macronodular adrenal hyperplasia, a rare etiology of primary adrenal Cushing’s syndrome, where they appear intermingled with adrenocortical cells in the hyperplastic cortex. In addition, the genetic events which cause the disease favor abnormal adrenal differenciation that results in illicit expression of paracrine regulatory factors and their receptors in adrenocortical cells. All these defects constitute the molecular basis for aberrant autocrine/paracrine regulatory mechanisms which are likely to play a role in the pathophysiology of bilateral macronodular adrenal hyperplasia-associated hypercortisolism. The present review summarizes the current knowledge on this topic as well as the therapeutic perspectives offered by this new pathophysiological concept. |
| first_indexed | 2024-04-13T06:25:34Z |
| format | Article |
| id | doaj.art-7dba23a3c959424ead2bd5775b4989a8 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-13T06:25:34Z |
| publishDate | 2015-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-7dba23a3c959424ead2bd5775b4989a82022-12-22T02:58:27ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922015-04-01610.3389/fendo.2015.00034132518Cell-to-cell communication in bilateral macronodular adrenal hyperplasia causing hypercortisolismHerve eLefebvre0Herve eLefebvre1Herve eLefebvre2Celine eDuparc3Celine eDuparc4Gaetan ePrevost5Gaetan ePrevost6Gaetan ePrevost7Jerome eBertherat8Jerome eBertherat9Estelle eLouiset10Estelle eLouiset11Inserm U982/CHU et Université de RouenInstitute for Research and Innovation in Biomedicine, Rouen UniversityDepartment of Endocrinology, Diabetes and Metabolic Diseases, University Hospital of RouenInserm U982/CHU et Université de RouenInstitute for Research and Innovation in Biomedicine, Rouen UniversityInserm U982/CHU et Université de RouenInstitute for Research and Innovation in Biomedicine, Rouen UniversityDepartment of Endocrinology, Diabetes and Metabolic Diseases, University Hospital of RouenInstitut National de la Santé et de la Recherche Médicale, Unité 1016, Institut CochinDepartment of Endocrinology and Metabolic Diseases, Hôpital Cochin, Assistance Publique-Hôpitaux de ParisInserm U982/CHU et Université de RouenInstitute for Research and Innovation in Biomedicine, Rouen UniversityIt has been well established that, in the human adrenal gland, cortisol secretion is not only controlled by circulating corticotropin but is also influenced by a wide variety of bioactive signals, including conventional neurotransmitters and neuropeptides, released within the cortex by various cell types such as chromaffin cells, neurons, cells of the immune system, adipocytes and endothelial cells. These different types of cells are present in bilateral macronodular adrenal hyperplasia, a rare etiology of primary adrenal Cushing’s syndrome, where they appear intermingled with adrenocortical cells in the hyperplastic cortex. In addition, the genetic events which cause the disease favor abnormal adrenal differenciation that results in illicit expression of paracrine regulatory factors and their receptors in adrenocortical cells. All these defects constitute the molecular basis for aberrant autocrine/paracrine regulatory mechanisms which are likely to play a role in the pathophysiology of bilateral macronodular adrenal hyperplasia-associated hypercortisolism. The present review summarizes the current knowledge on this topic as well as the therapeutic perspectives offered by this new pathophysiological concept.http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00034/fullHyperplasiaLeptinSerotoninACTHvasopressinendothelin |
| spellingShingle | Herve eLefebvre Herve eLefebvre Herve eLefebvre Celine eDuparc Celine eDuparc Gaetan ePrevost Gaetan ePrevost Gaetan ePrevost Jerome eBertherat Jerome eBertherat Estelle eLouiset Estelle eLouiset Cell-to-cell communication in bilateral macronodular adrenal hyperplasia causing hypercortisolism Frontiers in Endocrinology Hyperplasia Leptin Serotonin ACTH vasopressin endothelin |
| title | Cell-to-cell communication in bilateral macronodular adrenal hyperplasia causing hypercortisolism |
| title_full | Cell-to-cell communication in bilateral macronodular adrenal hyperplasia causing hypercortisolism |
| title_fullStr | Cell-to-cell communication in bilateral macronodular adrenal hyperplasia causing hypercortisolism |
| title_full_unstemmed | Cell-to-cell communication in bilateral macronodular adrenal hyperplasia causing hypercortisolism |
| title_short | Cell-to-cell communication in bilateral macronodular adrenal hyperplasia causing hypercortisolism |
| title_sort | cell to cell communication in bilateral macronodular adrenal hyperplasia causing hypercortisolism |
| topic | Hyperplasia Leptin Serotonin ACTH vasopressin endothelin |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00034/full |
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