Formulation of polymeric nanoparticles loaded sorafenib; evaluation of cytotoxicity, molecular evaluation, and gene expression studies in lung and breast cancer cell lines

Formulation of polymeric nanoparticles loaded sorafenib; evaluation of cytotoxicity, molecular evaluation, and gene expression studies in lung and breast cancer cell lines

Sorafenib (SFB) is an anticancer drug with sparingly water solubility and reduced bioavailability. Nanoformulation of SFB can increase its dissolution rate and solubility. The current study aimed to formulate SFB in nanoparticles to improve their solubility. The sorafenib nanoparticles (SFB-PNs) wer...

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Bibliographic Details
Main Authors: Abdellatif Ahmed A. H., Ali Asmaa T., Bouazzaoui Abdellatif, Alsharidah Mansour, Al Rugaie Osamah, Tolba Nahla Sameh
Format: Article
Language:English
Published: De Gruyter 2022-02-01
Series:Nanotechnology Reviews
Subjects:
sorafenib
nanoparticles
a549 cell lines
mcf-7 cell lines
anticancer activities
Online Access:https://doi.org/10.1515/ntrev-2022-0058

Internet

https://doi.org/10.1515/ntrev-2022-0058

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