Blocking siglec-10hi tumor-associated macrophages improves anti-tumor immunity and enhances immunotherapy for hepatocellular carcinoma

Blocking siglec-10hi tumor-associated macrophages improves anti-tumor immunity and enhances immunotherapy for hepatocellular carcinoma

Abstract Background Tumor-associated macrophages (TAMs) promote key processes in the modulation of tumor microenvironment (TME). However, the clinical significance of heterogeneous subpopulations of TAMs in hepatocellular carcinoma (HCC) remains unknown. Methods HCC tissues from Zhongshan Hospital a...

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Bibliographic Details
Main Authors: Nan Xiao, Xiaodong Zhu, Kangshuai Li, Yifan Chen, Xuefeng Liu, Bin Xu, Ming Lei, Jiejie Xu, Hui-Chuan Sun
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Experimental Hematology & Oncology
Subjects:
Macrophages
Tumor microenvironment
Hepatocellular carcinoma
Immunotherapy
Immune evasion
Online Access:https://doi.org/10.1186/s40164-021-00230-5

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