Additional mechanisms conferring genetic susceptibility to Alzheimer's disease

Additional mechanisms conferring genetic susceptibility to Alzheimer's disease

Familial Alzheimer's disease (AD), mostly associated with early onset, is caused by mutations in three genes (APP, PSEN1 and PSEN2) involved in the production of the amyloid  peptide. In contrast, the molecular mechanisms that trigger the most common late onset sporadic AD remain largely unkno...

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Bibliographic Details
Main Authors: Miguel eCalero, Alberto eGomez-Ramos, Olga eCalero, Eduardo eSoriano, Jesus eAvila, Miguel eMedina
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Exome
Alzheimer
GWAS
neurodegeneration
Epistasis
Risk factors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00138/full

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