A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis

A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis

Hypertension-associated end-organ damage commonly leads to cardiac and renal fibrosis. As no effective anti-fibrotic therapy currently exists, the unchecked progression of fibrogenesis manifests as cardio-renal failure and early death. We have previously shown that FATp300—p300 with intrinsic factor...

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Bibliographic Details
Main Authors: Rahul Rai, Suresh K. Verma, David Kim, Veronica Ramirez, Elizabeth Lux, Chengjin Li, Susmita Sahoo, Lisa D. Wilsbacher, Douglas E. Vaughan, Susan E. Quaggin, Asish K. Ghosh
Format: Article
Language:English
Published: Taylor & Francis Group 2017-11-01
Series:Epigenetics
Subjects:
acetyltransferase p300
angiotensin ii
cardiac fibrosis
epigenetics
fibroblasts
hypertension
podocytes
renal fibrosis
small molecule inhibitors
tgf-β
Online Access:http://dx.doi.org/10.1080/15592294.2017.1370173

Internet

http://dx.doi.org/10.1080/15592294.2017.1370173

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