Importance of household-level risk factors in explaining micro-epidemiology of asymptomatic malaria infections in Ratanakiri Province, Cambodia
Abstract Heterogeneity in malaria risk is considered a challenge for malaria elimination. A cross-sectional study was conducted to describe and explain micro-epidemiological variation in Plasmodium infection prevalence at household and village level in three villages in Ratanakiri Province, Cambodia...
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| Format: | Article |
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Nature Portfolio
2018-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-018-30193-3 |
| _version_ | 1819202653831299072 |
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| author | Melanie Bannister-Tyrrell Set Srun Vincent Sluydts Charlotte Gryseels Vanna Mean Saorin Kim Mao Sokny Koen Peeters Grietens Marc Coosemans Didier Menard Sochantha Tho Wim Van Bortel Lies Durnez |
| author_facet | Melanie Bannister-Tyrrell Set Srun Vincent Sluydts Charlotte Gryseels Vanna Mean Saorin Kim Mao Sokny Koen Peeters Grietens Marc Coosemans Didier Menard Sochantha Tho Wim Van Bortel Lies Durnez |
| author_sort | Melanie Bannister-Tyrrell |
| collection | DOAJ |
| description | Abstract Heterogeneity in malaria risk is considered a challenge for malaria elimination. A cross-sectional study was conducted to describe and explain micro-epidemiological variation in Plasmodium infection prevalence at household and village level in three villages in Ratanakiri Province, Cambodia. A two-level logistic regression model with a random intercept fitted for each household was used to model the odds of Plasmodium infection, with sequential adjustment for individual-level then household-level risk factors. Individual-level risk factors for Plasmodium infection included hammock net use and frequency of evening outdoor farm gatherings in adults, and older age in children. Household-level risk factors included house wall material, crop types, and satellite dish and farm machine ownership. Individual-level risk factors did not explain differences in odds of Plasmodium infection between households or between villages. In contrast, once household-level risk factors were taken into account, there was no significant difference in odds of Plasmodium infection between households and between villages. This study shows the importance of ongoing indoor and peridomestic transmission in a region where forest workers and mobile populations have previously been the focus of attention. Interventions targeting malaria risk at household level should be further explored. |
| first_indexed | 2024-12-23T04:07:27Z |
| format | Article |
| id | doaj.art-7dbda5c5ec1b4623bb85f41a1f50a4b2 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-23T04:07:27Z |
| publishDate | 2018-08-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-7dbda5c5ec1b4623bb85f41a1f50a4b22022-12-21T18:00:36ZengNature PortfolioScientific Reports2045-23222018-08-018111510.1038/s41598-018-30193-3Importance of household-level risk factors in explaining micro-epidemiology of asymptomatic malaria infections in Ratanakiri Province, CambodiaMelanie Bannister-Tyrrell0Set Srun1Vincent Sluydts2Charlotte Gryseels3Vanna Mean4Saorin Kim5Mao Sokny6Koen Peeters Grietens7Marc Coosemans8Didier Menard9Sochantha Tho10Wim Van Bortel11Lies Durnez12Institute of Tropical MedicineNational Centre for Parasitology, Entomology and Malaria ControlInstitute of Tropical MedicineInstitute of Tropical MedicineRatanakiri Provincial Health DepartmentInstitut Pasteur du CambodgeNational Centre for Parasitology, Entomology and Malaria ControlInstitute of Tropical MedicineInstitute of Tropical MedicineInstitut Pasteur du CambodgeNational Centre for Parasitology, Entomology and Malaria ControlInstitute of Tropical MedicineInstitute of Tropical MedicineAbstract Heterogeneity in malaria risk is considered a challenge for malaria elimination. A cross-sectional study was conducted to describe and explain micro-epidemiological variation in Plasmodium infection prevalence at household and village level in three villages in Ratanakiri Province, Cambodia. A two-level logistic regression model with a random intercept fitted for each household was used to model the odds of Plasmodium infection, with sequential adjustment for individual-level then household-level risk factors. Individual-level risk factors for Plasmodium infection included hammock net use and frequency of evening outdoor farm gatherings in adults, and older age in children. Household-level risk factors included house wall material, crop types, and satellite dish and farm machine ownership. Individual-level risk factors did not explain differences in odds of Plasmodium infection between households or between villages. In contrast, once household-level risk factors were taken into account, there was no significant difference in odds of Plasmodium infection between households and between villages. This study shows the importance of ongoing indoor and peridomestic transmission in a region where forest workers and mobile populations have previously been the focus of attention. Interventions targeting malaria risk at household level should be further explored.https://doi.org/10.1038/s41598-018-30193-3 |
| spellingShingle | Melanie Bannister-Tyrrell Set Srun Vincent Sluydts Charlotte Gryseels Vanna Mean Saorin Kim Mao Sokny Koen Peeters Grietens Marc Coosemans Didier Menard Sochantha Tho Wim Van Bortel Lies Durnez Importance of household-level risk factors in explaining micro-epidemiology of asymptomatic malaria infections in Ratanakiri Province, Cambodia Scientific Reports |
| title | Importance of household-level risk factors in explaining micro-epidemiology of asymptomatic malaria infections in Ratanakiri Province, Cambodia |
| title_full | Importance of household-level risk factors in explaining micro-epidemiology of asymptomatic malaria infections in Ratanakiri Province, Cambodia |
| title_fullStr | Importance of household-level risk factors in explaining micro-epidemiology of asymptomatic malaria infections in Ratanakiri Province, Cambodia |
| title_full_unstemmed | Importance of household-level risk factors in explaining micro-epidemiology of asymptomatic malaria infections in Ratanakiri Province, Cambodia |
| title_short | Importance of household-level risk factors in explaining micro-epidemiology of asymptomatic malaria infections in Ratanakiri Province, Cambodia |
| title_sort | importance of household level risk factors in explaining micro epidemiology of asymptomatic malaria infections in ratanakiri province cambodia |
| url | https://doi.org/10.1038/s41598-018-30193-3 |
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