Variation in Mycobacterium tuberculosis population structure in Iran: a systemic review and meta-analysis
Abstract Background Acquiring comprehensive insight into the dynamics of Mycobacterium tuberculosis (Mtb) population structure is an essential step to adopt effective tuberculosis (TB) control strategies and improve therapeutic methods and vaccines. Accordingly, we performed this systematic review a...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-01-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-020-05639-7 |
| _version_ | 1819320575720423424 |
|---|---|
| author | Shima Hadifar Abolfazl Fateh Vahid Pourbarkhordar Seyed Davar Siadat Shayan Mostafaei Farzam Vaziri |
| author_facet | Shima Hadifar Abolfazl Fateh Vahid Pourbarkhordar Seyed Davar Siadat Shayan Mostafaei Farzam Vaziri |
| author_sort | Shima Hadifar |
| collection | DOAJ |
| description | Abstract Background Acquiring comprehensive insight into the dynamics of Mycobacterium tuberculosis (Mtb) population structure is an essential step to adopt effective tuberculosis (TB) control strategies and improve therapeutic methods and vaccines. Accordingly, we performed this systematic review and meta-analysis to determine the overall prevalence of Mtb genotypes/ sublineages in Iran. Methods We carried out a comprehensive literature search using the international databases of MEDLINE and Scopus as well as Iranian databases. Articles published until April 2020 were selected based on the PRISMA flow diagram. The overall prevalence of the Mtb genotypes/sublineage in Iran was determined using the random effects or fixed effect model. The metafor R package and MedCalc software were employed for performing this meta-analysis. Results We identified 34 studies for inclusion in this study, containing 8329 clinical samples. Based on the pooled prevalence of the Mtb genotypes, NEW1 (21.94, 95% CI: 16.41–28.05%), CAS (19.21, 95% CI: 14.95–23.86%), EAI (12.95, 95% CI: 7.58–19.47%), and T (12.16, 95% CI: 9.18–15.50%) were characterized as the dominant circulating genotypes in Iran. West African (L 5/6), Cameroon, TUR and H37Rv were identified as genotypes with the lowest prevalence in Iran (< 2%). The highest pooled prevalence rates of multidrug-resistant strains were related to Beijing (2.52, 95% CI) and CAS (1.21, 95% CI). Conclusions This systematic review showed that Mtb populations are genetically diverse in Iran, and further studies are needed to gain a better insight into the national diversity of Mtb populations and their drug resistance pattern. |
| first_indexed | 2024-12-24T11:21:46Z |
| format | Article |
| id | doaj.art-7dbe6e4fae594c16b5b15b98f9168634 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-24T11:21:46Z |
| publishDate | 2021-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-7dbe6e4fae594c16b5b15b98f91686342022-12-21T16:58:13ZengBMCBMC Infectious Diseases1471-23342021-01-0121111110.1186/s12879-020-05639-7Variation in Mycobacterium tuberculosis population structure in Iran: a systemic review and meta-analysisShima Hadifar0Abolfazl Fateh1Vahid Pourbarkhordar2Seyed Davar Siadat3Shayan Mostafaei4Farzam Vaziri5Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of IranDepartment of Mycobacteriology and Pulmonary Research, Pasteur Institute of IranDepartment of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Science, Isfahan University of Medical ScienceDepartment of Mycobacteriology and Pulmonary Research, Pasteur Institute of IranDepartment of Biostatistics, School of Health, Kermanshah University of Medical SciencesDepartment of Mycobacteriology and Pulmonary Research, Pasteur Institute of IranAbstract Background Acquiring comprehensive insight into the dynamics of Mycobacterium tuberculosis (Mtb) population structure is an essential step to adopt effective tuberculosis (TB) control strategies and improve therapeutic methods and vaccines. Accordingly, we performed this systematic review and meta-analysis to determine the overall prevalence of Mtb genotypes/ sublineages in Iran. Methods We carried out a comprehensive literature search using the international databases of MEDLINE and Scopus as well as Iranian databases. Articles published until April 2020 were selected based on the PRISMA flow diagram. The overall prevalence of the Mtb genotypes/sublineage in Iran was determined using the random effects or fixed effect model. The metafor R package and MedCalc software were employed for performing this meta-analysis. Results We identified 34 studies for inclusion in this study, containing 8329 clinical samples. Based on the pooled prevalence of the Mtb genotypes, NEW1 (21.94, 95% CI: 16.41–28.05%), CAS (19.21, 95% CI: 14.95–23.86%), EAI (12.95, 95% CI: 7.58–19.47%), and T (12.16, 95% CI: 9.18–15.50%) were characterized as the dominant circulating genotypes in Iran. West African (L 5/6), Cameroon, TUR and H37Rv were identified as genotypes with the lowest prevalence in Iran (< 2%). The highest pooled prevalence rates of multidrug-resistant strains were related to Beijing (2.52, 95% CI) and CAS (1.21, 95% CI). Conclusions This systematic review showed that Mtb populations are genetically diverse in Iran, and further studies are needed to gain a better insight into the national diversity of Mtb populations and their drug resistance pattern.https://doi.org/10.1186/s12879-020-05639-7Mycobacterium tuberculosisGenotypeDiversityMeta-analysisIran |
| spellingShingle | Shima Hadifar Abolfazl Fateh Vahid Pourbarkhordar Seyed Davar Siadat Shayan Mostafaei Farzam Vaziri Variation in Mycobacterium tuberculosis population structure in Iran: a systemic review and meta-analysis BMC Infectious Diseases Mycobacterium tuberculosis Genotype Diversity Meta-analysis Iran |
| title | Variation in Mycobacterium tuberculosis population structure in Iran: a systemic review and meta-analysis |
| title_full | Variation in Mycobacterium tuberculosis population structure in Iran: a systemic review and meta-analysis |
| title_fullStr | Variation in Mycobacterium tuberculosis population structure in Iran: a systemic review and meta-analysis |
| title_full_unstemmed | Variation in Mycobacterium tuberculosis population structure in Iran: a systemic review and meta-analysis |
| title_short | Variation in Mycobacterium tuberculosis population structure in Iran: a systemic review and meta-analysis |
| title_sort | variation in mycobacterium tuberculosis population structure in iran a systemic review and meta analysis |
| topic | Mycobacterium tuberculosis Genotype Diversity Meta-analysis Iran |
| url | https://doi.org/10.1186/s12879-020-05639-7 |
| work_keys_str_mv | AT shimahadifar variationinmycobacteriumtuberculosispopulationstructureiniranasystemicreviewandmetaanalysis AT abolfazlfateh variationinmycobacteriumtuberculosispopulationstructureiniranasystemicreviewandmetaanalysis AT vahidpourbarkhordar variationinmycobacteriumtuberculosispopulationstructureiniranasystemicreviewandmetaanalysis AT seyeddavarsiadat variationinmycobacteriumtuberculosispopulationstructureiniranasystemicreviewandmetaanalysis AT shayanmostafaei variationinmycobacteriumtuberculosispopulationstructureiniranasystemicreviewandmetaanalysis AT farzamvaziri variationinmycobacteriumtuberculosispopulationstructureiniranasystemicreviewandmetaanalysis |