Acute Pharmacological Effects and Oral Fluid Concentrations of the Synthetic Cannabinoids JWH-122 and JWH-210 in Humans After Self-Administration: An Observational Study
Synthetic cannabinoids (SCs) are a group of new psychoactive drugs used recreationally with potential health risks. They are monitored by the EU Early Warning System since 2010 due to severe adverse effects on consumers. JWH-122 and JWH-210 are naphthoylindole SCs and potent cannabinoid receptor CB1...
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| Format: | Article |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.705643/full |
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| author | Lucia Martínez Lucia Martínez Nunzia La Maida Esther Papaseit Esther Papaseit Clara Pérez-Mañá Clara Pérez-Mañá Lourdes Poyatos Lourdes Poyatos Manuela Pellegrini Simona Pichini Mireia Ventura Liliana Galindo Liliana Galindo Francesco Paolo Busardò Magí Farré Magí Farré |
| author_facet | Lucia Martínez Lucia Martínez Nunzia La Maida Esther Papaseit Esther Papaseit Clara Pérez-Mañá Clara Pérez-Mañá Lourdes Poyatos Lourdes Poyatos Manuela Pellegrini Simona Pichini Mireia Ventura Liliana Galindo Liliana Galindo Francesco Paolo Busardò Magí Farré Magí Farré |
| author_sort | Lucia Martínez |
| collection | DOAJ |
| description | Synthetic cannabinoids (SCs) are a group of new psychoactive drugs used recreationally with potential health risks. They are monitored by the EU Early Warning System since 2010 due to severe adverse effects on consumers. JWH-122 and JWH-210 are naphthoylindole SCs and potent cannabinoid receptor CB1 and CB2 agonists. Information about the effects of SCs usually is available from intoxication cases and surveys, and few studies on humans after controlled administration or observational/naturalistic studies using standardized measures of cardiovascular and subjective effects are available. The aim of this study was to evaluate the acute pharmacological effects of JWH-122 and JWH-210 recreational consumption in a 4 h observational study and assess their disposition in oral fluid (OF). Sixteen volunteers self-administered 1 mg dose of JWH-122 (n = 8) or 2.25 mg mean dose of JWH-210 (range 2–3 mg, n = 8) by inhalation (smoking). Physiological parameters including blood pressure (systolic and diastolic), heart rate (HR), and cutaneous temperature were measured. A set of visual analog scales, the 49-item short-form version of the Addiction Research Center Inventory (ARCI), and the Evaluation of the Subjective Effects of Substances with Abuse Potential (VESSPA-SSE) were used for the evaluation of subjective effects. OF was collected at baseline and at 10, 20, and 40 min and 1, 2, 3, and 4 h after self-administration. Statistically significant increases in systolic blood pressure (SBP), diastolic blood pressure (DBP), and HR were observed after JWH-122 self-administration but not after JWH-210 self-administration. JWH-210 self-administration produced significant changes in subjective drug effects, similar to those induced by THC (intensity, high, good effects, and hunger). The subjective effects following JWH-122 consumption were minimal. The maximal effects were mostly observed 20 min after intake. JWH-122 and JWH 210 OF concentration reached a peak 20 min after administration and could not be detected after 3 h. The results demonstrated a different pattern of effects of these two SCs. Due to the limitations of our observational study, further research with a larger sample and controlled studies are needed to better define the acute pharmacological effect and health risk profile of JWH-122 and JWH-210. |
| first_indexed | 2024-12-16T17:57:20Z |
| format | Article |
| id | doaj.art-7dbefa39f53a4d48bf0267a712b61976 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-16T17:57:20Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pharmacology |
| spelling | doaj.art-7dbefa39f53a4d48bf0267a712b619762022-12-21T22:22:08ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-08-011210.3389/fphar.2021.705643705643Acute Pharmacological Effects and Oral Fluid Concentrations of the Synthetic Cannabinoids JWH-122 and JWH-210 in Humans After Self-Administration: An Observational StudyLucia Martínez0Lucia Martínez1Nunzia La Maida2Esther Papaseit3Esther Papaseit4Clara Pérez-Mañá5Clara Pérez-Mañá6Lourdes Poyatos7Lourdes Poyatos8Manuela Pellegrini9Simona Pichini10Mireia Ventura11Liliana Galindo12Liliana Galindo13Francesco Paolo Busardò14Magí Farré15Magí Farré16Clinical Pharmacology Unit, Hospital Universitari Germans Trias i Pujol, Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), Barcelona, SpainClinical Pharmacology Department, Hospital Universitario La Paz, Madrid, SpainDepartment of Excellence of Biomedical Science and Public Health, University “Politecnica delle Marche”, Ancona, ItalyClinical Pharmacology Unit, Hospital Universitari Germans Trias i Pujol, Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), Barcelona, SpainDepartment of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona, Cerdanyola del Vallés, SpainClinical Pharmacology Unit, Hospital Universitari Germans Trias i Pujol, Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), Barcelona, SpainDepartment of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona, Cerdanyola del Vallés, SpainClinical Pharmacology Unit, Hospital Universitari Germans Trias i Pujol, Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), Barcelona, SpainDepartment of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona, Cerdanyola del Vallés, SpainNational Centre on Addiction and Doping, Istituto Superiore di Sanità, Rome, ItalyNational Centre on Addiction and Doping, Istituto Superiore di Sanità, Rome, ItalyEnergy Control, Associació Benestar i Desenvolupament, Barcelona, SpainEnergy Control, Associació Benestar i Desenvolupament, Barcelona, SpainDepartment of Psychiatry, University of Cambridge/Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United KingdomDepartment of Excellence of Biomedical Science and Public Health, University “Politecnica delle Marche”, Ancona, ItalyClinical Pharmacology Unit, Hospital Universitari Germans Trias i Pujol, Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), Barcelona, SpainDepartment of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona, Cerdanyola del Vallés, SpainSynthetic cannabinoids (SCs) are a group of new psychoactive drugs used recreationally with potential health risks. They are monitored by the EU Early Warning System since 2010 due to severe adverse effects on consumers. JWH-122 and JWH-210 are naphthoylindole SCs and potent cannabinoid receptor CB1 and CB2 agonists. Information about the effects of SCs usually is available from intoxication cases and surveys, and few studies on humans after controlled administration or observational/naturalistic studies using standardized measures of cardiovascular and subjective effects are available. The aim of this study was to evaluate the acute pharmacological effects of JWH-122 and JWH-210 recreational consumption in a 4 h observational study and assess their disposition in oral fluid (OF). Sixteen volunteers self-administered 1 mg dose of JWH-122 (n = 8) or 2.25 mg mean dose of JWH-210 (range 2–3 mg, n = 8) by inhalation (smoking). Physiological parameters including blood pressure (systolic and diastolic), heart rate (HR), and cutaneous temperature were measured. A set of visual analog scales, the 49-item short-form version of the Addiction Research Center Inventory (ARCI), and the Evaluation of the Subjective Effects of Substances with Abuse Potential (VESSPA-SSE) were used for the evaluation of subjective effects. OF was collected at baseline and at 10, 20, and 40 min and 1, 2, 3, and 4 h after self-administration. Statistically significant increases in systolic blood pressure (SBP), diastolic blood pressure (DBP), and HR were observed after JWH-122 self-administration but not after JWH-210 self-administration. JWH-210 self-administration produced significant changes in subjective drug effects, similar to those induced by THC (intensity, high, good effects, and hunger). The subjective effects following JWH-122 consumption were minimal. The maximal effects were mostly observed 20 min after intake. JWH-122 and JWH 210 OF concentration reached a peak 20 min after administration and could not be detected after 3 h. The results demonstrated a different pattern of effects of these two SCs. Due to the limitations of our observational study, further research with a larger sample and controlled studies are needed to better define the acute pharmacological effect and health risk profile of JWH-122 and JWH-210.https://www.frontiersin.org/articles/10.3389/fphar.2021.705643/fullJWH-122JWH-210synthetic cannabinoid receptor agonists (SCRAs)physiological effectssubjective effects |
| spellingShingle | Lucia Martínez Lucia Martínez Nunzia La Maida Esther Papaseit Esther Papaseit Clara Pérez-Mañá Clara Pérez-Mañá Lourdes Poyatos Lourdes Poyatos Manuela Pellegrini Simona Pichini Mireia Ventura Liliana Galindo Liliana Galindo Francesco Paolo Busardò Magí Farré Magí Farré Acute Pharmacological Effects and Oral Fluid Concentrations of the Synthetic Cannabinoids JWH-122 and JWH-210 in Humans After Self-Administration: An Observational Study Frontiers in Pharmacology JWH-122 JWH-210 synthetic cannabinoid receptor agonists (SCRAs) physiological effects subjective effects |
| title | Acute Pharmacological Effects and Oral Fluid Concentrations of the Synthetic Cannabinoids JWH-122 and JWH-210 in Humans After Self-Administration: An Observational Study |
| title_full | Acute Pharmacological Effects and Oral Fluid Concentrations of the Synthetic Cannabinoids JWH-122 and JWH-210 in Humans After Self-Administration: An Observational Study |
| title_fullStr | Acute Pharmacological Effects and Oral Fluid Concentrations of the Synthetic Cannabinoids JWH-122 and JWH-210 in Humans After Self-Administration: An Observational Study |
| title_full_unstemmed | Acute Pharmacological Effects and Oral Fluid Concentrations of the Synthetic Cannabinoids JWH-122 and JWH-210 in Humans After Self-Administration: An Observational Study |
| title_short | Acute Pharmacological Effects and Oral Fluid Concentrations of the Synthetic Cannabinoids JWH-122 and JWH-210 in Humans After Self-Administration: An Observational Study |
| title_sort | acute pharmacological effects and oral fluid concentrations of the synthetic cannabinoids jwh 122 and jwh 210 in humans after self administration an observational study |
| topic | JWH-122 JWH-210 synthetic cannabinoid receptor agonists (SCRAs) physiological effects subjective effects |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.705643/full |
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