Selenium-Containing Agents Acting on Cancer—A New Hope?
Selenium-containing agents are more and more considered as an innovative potential treatment option for cancer. Light is shed not only on the considerable advancements made in understanding the complex biology and chemistry related to selenium-containing small molecules but also on Se-nanoparticles....
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/1/104 |
| _version_ | 1827622585141035008 |
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| author | Sabrina Garbo Silvia Di Giacomo Dorota Łażewska Ewelina Honkisz-Orzechowska Antonella Di Sotto Rossella Fioravanti Clemens Zwergel Cecilia Battistelli |
| author_facet | Sabrina Garbo Silvia Di Giacomo Dorota Łażewska Ewelina Honkisz-Orzechowska Antonella Di Sotto Rossella Fioravanti Clemens Zwergel Cecilia Battistelli |
| author_sort | Sabrina Garbo |
| collection | DOAJ |
| description | Selenium-containing agents are more and more considered as an innovative potential treatment option for cancer. Light is shed not only on the considerable advancements made in understanding the complex biology and chemistry related to selenium-containing small molecules but also on Se-nanoparticles. Numerous Se-containing agents have been widely investigated in recent years in cancer therapy in relation to tumour development and dissemination, drug delivery, multidrug resistance (MDR) and immune system-related (anti)cancer effects. Despite numerous efforts, Se-agents apart from selenocysteine and selenomethionine have not yet reached clinical trials for cancer therapy. The purpose of this review is to provide a concise critical overview of the current state of the art in the development of highly potent target-specific Se-containing agents. |
| first_indexed | 2024-03-09T11:28:33Z |
| format | Article |
| id | doaj.art-7dc09047977e45b1a873ba650af1785f |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T11:28:33Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-7dc09047977e45b1a873ba650af1785f2023-11-30T23:57:42ZengMDPI AGPharmaceutics1999-49232022-12-0115110410.3390/pharmaceutics15010104Selenium-Containing Agents Acting on Cancer—A New Hope?Sabrina Garbo0Silvia Di Giacomo1Dorota Łażewska2Ewelina Honkisz-Orzechowska3Antonella Di Sotto4Rossella Fioravanti5Clemens Zwergel6Cecilia Battistelli7Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, ItalyDepartment of Physiology and Pharmacology “V. Erspamer”, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyDepartment of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, PolandDepartment of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, PolandDepartment of Physiology and Pharmacology “V. Erspamer”, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyDepartment of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, ItalySelenium-containing agents are more and more considered as an innovative potential treatment option for cancer. Light is shed not only on the considerable advancements made in understanding the complex biology and chemistry related to selenium-containing small molecules but also on Se-nanoparticles. Numerous Se-containing agents have been widely investigated in recent years in cancer therapy in relation to tumour development and dissemination, drug delivery, multidrug resistance (MDR) and immune system-related (anti)cancer effects. Despite numerous efforts, Se-agents apart from selenocysteine and selenomethionine have not yet reached clinical trials for cancer therapy. The purpose of this review is to provide a concise critical overview of the current state of the art in the development of highly potent target-specific Se-containing agents.https://www.mdpi.com/1999-4923/15/1/104seleniumcancercancer therapyimmunotherapysmall organic Se-containing compoundsSe-nanoparticles |
| spellingShingle | Sabrina Garbo Silvia Di Giacomo Dorota Łażewska Ewelina Honkisz-Orzechowska Antonella Di Sotto Rossella Fioravanti Clemens Zwergel Cecilia Battistelli Selenium-Containing Agents Acting on Cancer—A New Hope? Pharmaceutics selenium cancer cancer therapy immunotherapy small organic Se-containing compounds Se-nanoparticles |
| title | Selenium-Containing Agents Acting on Cancer—A New Hope? |
| title_full | Selenium-Containing Agents Acting on Cancer—A New Hope? |
| title_fullStr | Selenium-Containing Agents Acting on Cancer—A New Hope? |
| title_full_unstemmed | Selenium-Containing Agents Acting on Cancer—A New Hope? |
| title_short | Selenium-Containing Agents Acting on Cancer—A New Hope? |
| title_sort | selenium containing agents acting on cancer a new hope |
| topic | selenium cancer cancer therapy immunotherapy small organic Se-containing compounds Se-nanoparticles |
| url | https://www.mdpi.com/1999-4923/15/1/104 |
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