Hypothalamic Renin–Angiotensin System and Lipid Metabolism: Effects of Virgin Olive Oil versus Butter in the Diet
The brain renin–angiotensin system (RAS) has been recently involved in the homeostatic regulation of energy. Our goal was to analyse the influence of a diet rich in saturated fatty acids (butter) against one enriched in monounsaturated fatty acids (olive oil) on hypothalamic RAS, and their relations...
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MDPI AG
2021-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/2/480 |
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| author | Ana Belén Segarra Germán Domínguez-Vías José Redondo Magdalena Martínez-Cañamero Manuel Ramírez-Sánchez Isabel Prieto |
| author_facet | Ana Belén Segarra Germán Domínguez-Vías José Redondo Magdalena Martínez-Cañamero Manuel Ramírez-Sánchez Isabel Prieto |
| author_sort | Ana Belén Segarra |
| collection | DOAJ |
| description | The brain renin–angiotensin system (RAS) has been recently involved in the homeostatic regulation of energy. Our goal was to analyse the influence of a diet rich in saturated fatty acids (butter) against one enriched in monounsaturated fatty acids (olive oil) on hypothalamic RAS, and their relationship with the metabolism of fatty acids. Increases in body weight and visceral fat, together with an increase in aminopeptidase A expression and reductions in AngII and AngIV were observed in the hypothalamus of animals fed with the butter diet. In this group, a marked reduction in the expression of genes related to lipid metabolism (LPL, CD36, and CPT-1) was observed in liver and muscle. No changes were found in terms of body weight, total visceral fat and the expression of hepatic genes related to fatty acid metabolism in the olive oil diet. The expressions of LPL and CD36 were reduced in the muscles, although the decrease was lower than in the butter diet. At the same time, the fasting levels of leptin were reduced, no changes were observed in the hypothalamic expression of aminopeptidase A and decreases were noted in the levels of AngII, AngIV and AngIII. These results support that the type of dietary fat is able to modify the hypothalamic profile of RAS and the body energy balance, related to changes in lipid metabolism. |
| first_indexed | 2024-03-09T06:17:50Z |
| format | Article |
| id | doaj.art-7dc0cfff680b437190e51e8dfdf7f371 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T06:17:50Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-7dc0cfff680b437190e51e8dfdf7f3712023-12-03T11:51:28ZengMDPI AGNutrients2072-66432021-01-0113248010.3390/nu13020480Hypothalamic Renin–Angiotensin System and Lipid Metabolism: Effects of Virgin Olive Oil versus Butter in the DietAna Belén Segarra0Germán Domínguez-Vías1José Redondo2Magdalena Martínez-Cañamero3Manuel Ramírez-Sánchez4Isabel Prieto5Unit of Physiology, Department of Health Sciences, University of Jaén, Las Lagunillas, 23071 Jaén, SpainDepartment of Physiology, Faculty of Health Sciences, Ceuta, University of Granada, 18071 Granada, SpainUnit of Physiology, Department of Health Sciences, University of Jaén, Las Lagunillas, 23071 Jaén, SpainUnit of Microbiology, Department of Health Sciences, University of Jaén, Las Lagunillas, 23071 Jaén, SpainUnit of Physiology, Department of Health Sciences, University of Jaén, Las Lagunillas, 23071 Jaén, SpainUnit of Physiology, Department of Health Sciences, University of Jaén, Las Lagunillas, 23071 Jaén, SpainThe brain renin–angiotensin system (RAS) has been recently involved in the homeostatic regulation of energy. Our goal was to analyse the influence of a diet rich in saturated fatty acids (butter) against one enriched in monounsaturated fatty acids (olive oil) on hypothalamic RAS, and their relationship with the metabolism of fatty acids. Increases in body weight and visceral fat, together with an increase in aminopeptidase A expression and reductions in AngII and AngIV were observed in the hypothalamus of animals fed with the butter diet. In this group, a marked reduction in the expression of genes related to lipid metabolism (LPL, CD36, and CPT-1) was observed in liver and muscle. No changes were found in terms of body weight, total visceral fat and the expression of hepatic genes related to fatty acid metabolism in the olive oil diet. The expressions of LPL and CD36 were reduced in the muscles, although the decrease was lower than in the butter diet. At the same time, the fasting levels of leptin were reduced, no changes were observed in the hypothalamic expression of aminopeptidase A and decreases were noted in the levels of AngII, AngIV and AngIII. These results support that the type of dietary fat is able to modify the hypothalamic profile of RAS and the body energy balance, related to changes in lipid metabolism.https://www.mdpi.com/2072-6643/13/2/480virgin olive oilbrain renin–angiotensin systemfatty acid metabolismenergy balance |
| spellingShingle | Ana Belén Segarra Germán Domínguez-Vías José Redondo Magdalena Martínez-Cañamero Manuel Ramírez-Sánchez Isabel Prieto Hypothalamic Renin–Angiotensin System and Lipid Metabolism: Effects of Virgin Olive Oil versus Butter in the Diet Nutrients virgin olive oil brain renin–angiotensin system fatty acid metabolism energy balance |
| title | Hypothalamic Renin–Angiotensin System and Lipid Metabolism: Effects of Virgin Olive Oil versus Butter in the Diet |
| title_full | Hypothalamic Renin–Angiotensin System and Lipid Metabolism: Effects of Virgin Olive Oil versus Butter in the Diet |
| title_fullStr | Hypothalamic Renin–Angiotensin System and Lipid Metabolism: Effects of Virgin Olive Oil versus Butter in the Diet |
| title_full_unstemmed | Hypothalamic Renin–Angiotensin System and Lipid Metabolism: Effects of Virgin Olive Oil versus Butter in the Diet |
| title_short | Hypothalamic Renin–Angiotensin System and Lipid Metabolism: Effects of Virgin Olive Oil versus Butter in the Diet |
| title_sort | hypothalamic renin angiotensin system and lipid metabolism effects of virgin olive oil versus butter in the diet |
| topic | virgin olive oil brain renin–angiotensin system fatty acid metabolism energy balance |
| url | https://www.mdpi.com/2072-6643/13/2/480 |
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