Inhibition of PKC disrupts addiction-related memory

Inhibition of PKC disrupts addiction-related memory

The atypical PKC isoforms, PKMζ and PKCλ have been proposed as integral substrates of long-term memory. Inhibition of these isoforms has recently been demonstrated to be sufficient for impairing the expression and maintenance of long-term potentiation. Additionally, the pseudosubstrate inhibitor, ze...

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Bibliographic Details
Main Authors: Kristin K Howell, Bradley R Monk, Stephanie A Carmack, Oliver D Mrowczynski, Robert E Clark, Stephan G Anagnostaras
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-03-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Cocaine
Memory
PKC
sensitization
nonassociative
ZIP
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00070/full

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