FRC transplantation restores lymph node conduit defects in laminin α4–deficient mice

FRC transplantation restores lymph node conduit defects in laminin α4–deficient mice

Fibroblastic reticular cells (FRCs) play important roles in tolerance by producing laminin α4 (Lama4) and altering lymph node (LN) structure and function. The present study revealed the specific roles of extracellular matrix Lama4 in regulating LN conduits using FRC-specific KO mouse strains. FRC-de...

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Bibliographic Details
Main Authors: Lushen Li, Long Wu, Allison Kensiski, Jing Zhao, Marina W. Shirkey, Yang Song, Wenji Piao, Tianshu Zhang, Zhongcheng Mei, Samuel J. Gavzy, Bing Ma, Vikas Saxena, Young S. Lee, Yanbao Xiong, Xiaofei Li, Xiaoxuan Fan, Reza Abdi, Jonathan S. Bromberg
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-04-01
Series:JCI Insight
Subjects:
Immunology
Online Access:https://doi.org/10.1172/jci.insight.167816

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