The multifaceted virulence of adherent-invasive Escherichia coli
ABSTRACTThe surge in inflammatory bowel diseases, like Crohn’s disease (CD), is alarming. While the role of the gut microbiome in CD development is unresolved, the frequent isolation of adherent-invasive Escherichia coli (AIEC) strains from patient biopsies, together with their propensity to trigger...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2023.2172669 |
| _version_ | 1797236658838437888 |
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| author | Sarah Mansour Tahreem Asrar Wael Elhenawy |
| author_facet | Sarah Mansour Tahreem Asrar Wael Elhenawy |
| author_sort | Sarah Mansour |
| collection | DOAJ |
| description | ABSTRACTThe surge in inflammatory bowel diseases, like Crohn’s disease (CD), is alarming. While the role of the gut microbiome in CD development is unresolved, the frequent isolation of adherent-invasive Escherichia coli (AIEC) strains from patient biopsies, together with their propensity to trigger gut inflammation, underpin the potential role of these bacteria as disease modifiers. In this review, we explore the spectrum of AIEC pathogenesis, including their metabolic versatility in the gut. We describe how AIEC strains hijack the host defense mechanisms to evade immune attrition and promote inflammation. Furthermore, we highlight the key traits that differentiate AIEC from commensal E. coli. Deciphering the main components of AIEC virulence is cardinal to the discovery of the next generation of antimicrobials that can selectively eradicate CD-associated bacteria. |
| first_indexed | 2024-03-11T14:20:26Z |
| format | Article |
| id | doaj.art-7dc3d7dbeddc437ba8ea2a370c85404b |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-04-24T17:07:22Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-7dc3d7dbeddc437ba8ea2a370c85404b2024-03-28T22:38:19ZengTaylor & Francis GroupGut Microbes1949-09761949-09842023-12-0115110.1080/19490976.2023.2172669The multifaceted virulence of adherent-invasive Escherichia coliSarah Mansour0Tahreem Asrar1Wael Elhenawy2Department of Medical Microbiology & Immunology, Faculty of Medicine & Dentistry, University of Alberta, CanadaDepartment of Medical Microbiology & Immunology, Faculty of Medicine & Dentistry, University of Alberta, CanadaDepartment of Medical Microbiology & Immunology, Faculty of Medicine & Dentistry, University of Alberta, CanadaABSTRACTThe surge in inflammatory bowel diseases, like Crohn’s disease (CD), is alarming. While the role of the gut microbiome in CD development is unresolved, the frequent isolation of adherent-invasive Escherichia coli (AIEC) strains from patient biopsies, together with their propensity to trigger gut inflammation, underpin the potential role of these bacteria as disease modifiers. In this review, we explore the spectrum of AIEC pathogenesis, including their metabolic versatility in the gut. We describe how AIEC strains hijack the host defense mechanisms to evade immune attrition and promote inflammation. Furthermore, we highlight the key traits that differentiate AIEC from commensal E. coli. Deciphering the main components of AIEC virulence is cardinal to the discovery of the next generation of antimicrobials that can selectively eradicate CD-associated bacteria.https://www.tandfonline.com/doi/10.1080/19490976.2023.2172669InflammationCrohn’s diseaseadherent-invasiveE. colimetabolic adaptationimmune evasion |
| spellingShingle | Sarah Mansour Tahreem Asrar Wael Elhenawy The multifaceted virulence of adherent-invasive Escherichia coli Gut Microbes Inflammation Crohn’s disease adherent-invasiveE. coli metabolic adaptation immune evasion |
| title | The multifaceted virulence of adherent-invasive Escherichia coli |
| title_full | The multifaceted virulence of adherent-invasive Escherichia coli |
| title_fullStr | The multifaceted virulence of adherent-invasive Escherichia coli |
| title_full_unstemmed | The multifaceted virulence of adherent-invasive Escherichia coli |
| title_short | The multifaceted virulence of adherent-invasive Escherichia coli |
| title_sort | multifaceted virulence of adherent invasive escherichia coli |
| topic | Inflammation Crohn’s disease adherent-invasiveE. coli metabolic adaptation immune evasion |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2023.2172669 |
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