Recent advances of NFATc1 in rheumatoid arthritis-related bone destruction: mechanisms and potential therapeutic targets

Recent advances of NFATc1 in rheumatoid arthritis-related bone destruction: mechanisms and potential therapeutic targets

Abstract Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by inflammation of the synovial tissue and joint bone destruction, often leading to significant disability. The main pathological manifestation of joint deformity in RA patients is bone destruction, which o...

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Bibliographic Details
Main Authors: Hao Zheng, Yuexuan Liu, Yasi Deng, Yunzhe Li, Shiqi Liu, Yong Yang, Yun Qiu, Bin Li, Wenbing Sheng, Jinzhi Liu, Caiyun Peng, Wei Wang, Huanghe Yu
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Molecular Medicine
Subjects:
Rheumatoid arthritis
NFATc1
Bone destruction
RANKL/RANK
Osteoclast
Osteoclastogenesis
Online Access:https://doi.org/10.1186/s10020-024-00788-w

Internet

https://doi.org/10.1186/s10020-024-00788-w

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