LDP alleviates TKI-induced proteinuria through reversing the expression of RelA in renal tissues
Tyrosine kinase inhibitors (TKIs), as an important tumor therapy, can induce severe proteinuria that significantly affects anti-tumor therapy. Existing therapies against proteinuria induced by other etiologies are currently ineffective for TKI-induced proteinuria. It has been shown that various type...
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1095344/full |
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| author | Zhou Fu Su Zhang Su Zhang Xiaoying Gu Tao Guan Chengmeng Wang Jiaqi Zhang Yun Wang Hua Guo Lu Wang Lu Wang Ti Zhang Ti Zhang Ti Zhang |
| author_facet | Zhou Fu Su Zhang Su Zhang Xiaoying Gu Tao Guan Chengmeng Wang Jiaqi Zhang Yun Wang Hua Guo Lu Wang Lu Wang Ti Zhang Ti Zhang Ti Zhang |
| author_sort | Zhou Fu |
| collection | DOAJ |
| description | Tyrosine kinase inhibitors (TKIs), as an important tumor therapy, can induce severe proteinuria that significantly affects anti-tumor therapy. Existing therapies against proteinuria induced by other etiologies are currently ineffective for TKI-induced proteinuria. It has been shown that various types of proteinuria are related to podocyte damage caused by changes in the RelA signaling pathway. Our experiments confirmed that TKIs activate the renal RelA signaling pathway, and induce death of podocytes and destruction of the glomerular filtration barrier. Here we found that Liuwei Dihuang Pill (LDP) attenuated the inflammatory injury of podocytes through inhibiting activation of RelA, and subsequently relieved TKI-related proteinuria and prevented the progression of TMA and FSGS. Our finding indicated that LDP may be effective for the treatment of TKI-induced proteinuria, which is clinically significant. |
| first_indexed | 2024-04-10T21:40:25Z |
| format | Article |
| id | doaj.art-7dc59353fdbf4670b9631966469c81a7 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-10T21:40:25Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-7dc59353fdbf4670b9631966469c81a72023-01-19T05:02:36ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-01-011010.3389/fmed.2023.10953441095344LDP alleviates TKI-induced proteinuria through reversing the expression of RelA in renal tissuesZhou Fu0Su Zhang1Su Zhang2Xiaoying Gu3Tao Guan4Chengmeng Wang5Jiaqi Zhang6Yun Wang7Hua Guo8Lu Wang9Lu Wang10Ti Zhang11Ti Zhang12Ti Zhang13Key Laboratory of Cancer Prevention and Therapy, Department of Hepatobiliary Surgery, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, ChinaKey Laboratory of Cancer Prevention and Therapy, Department of Hepatobiliary Surgery, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, ChinaKey Laboratory of Cancer Prevention and Therapy, Department of Gynecologic Oncology, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, ChinaKey Laboratory of Cancer Prevention and Therapy, Department of Hepatobiliary Surgery, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, ChinaKey Laboratory of Cancer Prevention and Therapy, Department of Hepatobiliary Surgery, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, ChinaKey Laboratory of Cancer Prevention and Therapy, Department of Hepatobiliary Surgery, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, ChinaDepartment of Cell Biology and Medical Genetics, School of Basic Medical Science, Shanxi Medical University, Jinzhong, ChinaKey Laboratory of Cancer Prevention and Therapy, Department of Hepatobiliary Surgery, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, ChinaKey Laboratory of Cancer Prevention and Therapy, Department of Tumor Cell Biology, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, ChinaDepartment of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaKey Laboratory of Cancer Prevention and Therapy, Department of Hepatobiliary Surgery, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, ChinaDepartment of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaTyrosine kinase inhibitors (TKIs), as an important tumor therapy, can induce severe proteinuria that significantly affects anti-tumor therapy. Existing therapies against proteinuria induced by other etiologies are currently ineffective for TKI-induced proteinuria. It has been shown that various types of proteinuria are related to podocyte damage caused by changes in the RelA signaling pathway. Our experiments confirmed that TKIs activate the renal RelA signaling pathway, and induce death of podocytes and destruction of the glomerular filtration barrier. Here we found that Liuwei Dihuang Pill (LDP) attenuated the inflammatory injury of podocytes through inhibiting activation of RelA, and subsequently relieved TKI-related proteinuria and prevented the progression of TMA and FSGS. Our finding indicated that LDP may be effective for the treatment of TKI-induced proteinuria, which is clinically significant.https://www.frontiersin.org/articles/10.3389/fmed.2023.1095344/fullproteinuriatyrosine kinase inhibitorsLiuwei Dihuang Pilltumorhepatocellular carcinoma |
| spellingShingle | Zhou Fu Su Zhang Su Zhang Xiaoying Gu Tao Guan Chengmeng Wang Jiaqi Zhang Yun Wang Hua Guo Lu Wang Lu Wang Ti Zhang Ti Zhang Ti Zhang LDP alleviates TKI-induced proteinuria through reversing the expression of RelA in renal tissues Frontiers in Medicine proteinuria tyrosine kinase inhibitors Liuwei Dihuang Pill tumor hepatocellular carcinoma |
| title | LDP alleviates TKI-induced proteinuria through reversing the expression of RelA in renal tissues |
| title_full | LDP alleviates TKI-induced proteinuria through reversing the expression of RelA in renal tissues |
| title_fullStr | LDP alleviates TKI-induced proteinuria through reversing the expression of RelA in renal tissues |
| title_full_unstemmed | LDP alleviates TKI-induced proteinuria through reversing the expression of RelA in renal tissues |
| title_short | LDP alleviates TKI-induced proteinuria through reversing the expression of RelA in renal tissues |
| title_sort | ldp alleviates tki induced proteinuria through reversing the expression of rela in renal tissues |
| topic | proteinuria tyrosine kinase inhibitors Liuwei Dihuang Pill tumor hepatocellular carcinoma |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1095344/full |
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