Pathogenicity and transmission of a swine influenza A(H6N6) virus<subtitle>Risk assessment of H6N6 swine influenza A virus</subtitle>
Subtype H6 influenza A viruses (IAVs) are commonly detected in wild birds and domestic poultry and can infect humans. In 2010, a H6N6 virus emerged in southern China, and since then, it has caused sporadic infections among swine. We show that this virus binds to α2,6-linked and α2,3-linked sialic ac...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-01-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1038/emi.2017.3 |
| _version_ | 1797676963539714048 |
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| author | Hailiang Sun Bryan S Kaplan Minhui Guan Guihong Zhang Jianqiang Ye Li-Ping Long Sherry Blackmon Chun-Kai Yang Meng-Jung Chiang Hang Xie Nan Zhao Jim Cooley David F Smith Ming Liao Carol Cardona Lei Li George Peng Wang Richard Webby Xiu-Feng Wan |
| author_facet | Hailiang Sun Bryan S Kaplan Minhui Guan Guihong Zhang Jianqiang Ye Li-Ping Long Sherry Blackmon Chun-Kai Yang Meng-Jung Chiang Hang Xie Nan Zhao Jim Cooley David F Smith Ming Liao Carol Cardona Lei Li George Peng Wang Richard Webby Xiu-Feng Wan |
| author_sort | Hailiang Sun |
| collection | DOAJ |
| description | Subtype H6 influenza A viruses (IAVs) are commonly detected in wild birds and domestic poultry and can infect humans. In 2010, a H6N6 virus emerged in southern China, and since then, it has caused sporadic infections among swine. We show that this virus binds to α2,6-linked and α2,3-linked sialic acids. Mutations at residues 222 (alanine to valine) and 228 (glycine to serine) of the virus hemagglutinin (HA) affected its receptor-binding properties. Experiments showed that the virus has limited transmissibility between ferrets through direct contact or through inhalation of infectious aerosolized droplets. The internal genes of the influenza A(H1N1)pdm09 virus, which is prevalent in swine worldwide, increases the replication efficiency of H6N6 IAV in the lower respiratory tract of ferrets but not its transmissibility between ferrets. These findings suggest H6N6 swine IAV (SIV) currently poses a moderate risk to public health, but its evolution and spread should be closely monitored.Emerging Microbes & Infections (2017) 6, e17; doi:10.1038/emi.2017.3; published online 12 April 2017 |
| first_indexed | 2024-03-11T22:36:57Z |
| format | Article |
| id | doaj.art-7dca208f701d48f3a6f571ab6482c2e1 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-03-11T22:36:57Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-7dca208f701d48f3a6f571ab6482c2e12023-09-22T12:08:35ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512017-01-016111310.1038/emi.2017.3Pathogenicity and transmission of a swine influenza A(H6N6) virus<subtitle>Risk assessment of H6N6 swine influenza A virus</subtitle>Hailiang Sun0Bryan S Kaplan1Minhui Guan2Guihong Zhang3Jianqiang Ye4Li-Ping Long5Sherry Blackmon6Chun-Kai Yang7Meng-Jung Chiang8Hang Xie9Nan Zhao10Jim Cooley11David F Smith12Ming Liao13Carol Cardona14Lei Li15George Peng Wang16Richard Webby17Xiu-Feng Wan18Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39759, USADepartment of Infectious Diseases, St Jude Children’s Research Hospital, Memphis, TN 38105, USADepartment of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39759, USACollege of Veterinary Medicine, South China Agricultural University, Guangzhou 510462, Guangdong, ChinaDepartment of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39759, USADepartment of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39759, USADepartment of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39759, USADepartment of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39759, USALaboratory of Respiratory Viral Diseases, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, MD 20993, USALaboratory of Respiratory Viral Diseases, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, MD 20993, USADepartment of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39759, USADepartment of Population Medicine and Pathobiology, College of Veterinary MedicineMississippi State University, Mississippi State, MS 39759, USADepartment of Biochemistry, Glycomics Center, School of MedicineEmory University, Atlanta 30322, GA, USACollege of Veterinary Medicine, South China Agricultural University, Guangzhou 510462, Guangdong, ChinaCollege of Veterinary MedicineUniversity of Minnesota, St Paul, MN 30322, USADepartment of ChemistryGeorgia State University, Atlanta, GA 30302, USADepartment of ChemistryGeorgia State University, Atlanta, GA 30302, USADepartment of Infectious Diseases, St Jude Children’s Research Hospital, Memphis, TN 38105, USADepartment of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39759, USASubtype H6 influenza A viruses (IAVs) are commonly detected in wild birds and domestic poultry and can infect humans. In 2010, a H6N6 virus emerged in southern China, and since then, it has caused sporadic infections among swine. We show that this virus binds to α2,6-linked and α2,3-linked sialic acids. Mutations at residues 222 (alanine to valine) and 228 (glycine to serine) of the virus hemagglutinin (HA) affected its receptor-binding properties. Experiments showed that the virus has limited transmissibility between ferrets through direct contact or through inhalation of infectious aerosolized droplets. The internal genes of the influenza A(H1N1)pdm09 virus, which is prevalent in swine worldwide, increases the replication efficiency of H6N6 IAV in the lower respiratory tract of ferrets but not its transmissibility between ferrets. These findings suggest H6N6 swine IAV (SIV) currently poses a moderate risk to public health, but its evolution and spread should be closely monitored.Emerging Microbes & Infections (2017) 6, e17; doi:10.1038/emi.2017.3; published online 12 April 2017https://www.tandfonline.com/doi/10.1038/emi.2017.32009 H1N1 influenza virusaerosol transmissionglycan microarrayinfluenza A(H1N1)pdm09 virusreceptor bindingrisk assessment |
| spellingShingle | Hailiang Sun Bryan S Kaplan Minhui Guan Guihong Zhang Jianqiang Ye Li-Ping Long Sherry Blackmon Chun-Kai Yang Meng-Jung Chiang Hang Xie Nan Zhao Jim Cooley David F Smith Ming Liao Carol Cardona Lei Li George Peng Wang Richard Webby Xiu-Feng Wan Pathogenicity and transmission of a swine influenza A(H6N6) virus<subtitle>Risk assessment of H6N6 swine influenza A virus</subtitle> Emerging Microbes and Infections 2009 H1N1 influenza virus aerosol transmission glycan microarray influenza A(H1N1)pdm09 virus receptor binding risk assessment |
| title | Pathogenicity and transmission of a swine influenza A(H6N6) virus<subtitle>Risk assessment of H6N6 swine influenza A virus</subtitle> |
| title_full | Pathogenicity and transmission of a swine influenza A(H6N6) virus<subtitle>Risk assessment of H6N6 swine influenza A virus</subtitle> |
| title_fullStr | Pathogenicity and transmission of a swine influenza A(H6N6) virus<subtitle>Risk assessment of H6N6 swine influenza A virus</subtitle> |
| title_full_unstemmed | Pathogenicity and transmission of a swine influenza A(H6N6) virus<subtitle>Risk assessment of H6N6 swine influenza A virus</subtitle> |
| title_short | Pathogenicity and transmission of a swine influenza A(H6N6) virus<subtitle>Risk assessment of H6N6 swine influenza A virus</subtitle> |
| title_sort | pathogenicity and transmission of a swine influenza a h6n6 virus subtitle risk assessment of h6n6 swine influenza a virus subtitle |
| topic | 2009 H1N1 influenza virus aerosol transmission glycan microarray influenza A(H1N1)pdm09 virus receptor binding risk assessment |
| url | https://www.tandfonline.com/doi/10.1038/emi.2017.3 |
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