The Current State of Donor-Derived Cell-Free DNA Use in Allograft Monitoring in Kidney Transplantation
Renal transplantation is the definitive therapy for patients suffering from end-stage renal disease. Though there have been significant advances in immunosuppression in these patients, there is still up to 30% acute and subclinical rejection. Current standards employ lab markers of renal function an...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/10/1700 |
| _version_ | 1797472151998038016 |
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| author | Michael L. Kueht Laxmi Priya Dongur Matthew Cusick Heather L. Stevenson Muhammad Mujtaba |
| author_facet | Michael L. Kueht Laxmi Priya Dongur Matthew Cusick Heather L. Stevenson Muhammad Mujtaba |
| author_sort | Michael L. Kueht |
| collection | DOAJ |
| description | Renal transplantation is the definitive therapy for patients suffering from end-stage renal disease. Though there have been significant advances in immunosuppression in these patients, there is still up to 30% acute and subclinical rejection. Current standards employ lab markers of renal function and biopsy results for accurate diagnosis. However, donor derived cell-free DNA has been identified as a measurable lab test that may be able to adequately diagnose rejection at early stages, precluding the need for invasive procedures like biopsy. We obtained published data directly from companies that offer ddcfDNA assay tests and additionally conducted a literature review using databases like PUBMED and NIH U.S. National Library of Medicine. We comprehensively compare the most used ddcfDNA assays, delineate their respective limitations, and further explore future directions in the utility of ddcfDNA in renal transplant patients. |
| first_indexed | 2024-03-09T19:58:05Z |
| format | Article |
| id | doaj.art-7dcbd2e420734358952aed2ec3f79426 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T19:58:05Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-7dcbd2e420734358952aed2ec3f794262023-11-24T00:50:35ZengMDPI AGJournal of Personalized Medicine2075-44262022-10-011210170010.3390/jpm12101700The Current State of Donor-Derived Cell-Free DNA Use in Allograft Monitoring in Kidney TransplantationMichael L. Kueht0Laxmi Priya Dongur1Matthew Cusick2Heather L. Stevenson3Muhammad Mujtaba4Department of Surgery, Multiorgan Transplant and Hepatobiliary Surgery, University of Texas Medical Branch, Galveston, TX 77555, USADepartment of Surgery, Multiorgan Transplant and Hepatobiliary Surgery, University of Texas Medical Branch, Galveston, TX 77555, USADepartment of Pathology, Division of Histocompatibility and Immunogenetics, University of Michigan Medicine, Ann Arbor, MI 48109, USADepartment of Pathology, Transplant Pathology, University of Texas Medical Branch, Galveston, TX 77555, USADepartment of Medicine, Transplant Nephrology, University of Texas Medical Branch, Galveston, TX 77555, USARenal transplantation is the definitive therapy for patients suffering from end-stage renal disease. Though there have been significant advances in immunosuppression in these patients, there is still up to 30% acute and subclinical rejection. Current standards employ lab markers of renal function and biopsy results for accurate diagnosis. However, donor derived cell-free DNA has been identified as a measurable lab test that may be able to adequately diagnose rejection at early stages, precluding the need for invasive procedures like biopsy. We obtained published data directly from companies that offer ddcfDNA assay tests and additionally conducted a literature review using databases like PUBMED and NIH U.S. National Library of Medicine. We comprehensively compare the most used ddcfDNA assays, delineate their respective limitations, and further explore future directions in the utility of ddcfDNA in renal transplant patients.https://www.mdpi.com/2075-4426/12/10/1700renal transplantationT-cell mediated rejectionantibody-mediated rejectiondo-nor-derived cell-free DNA |
| spellingShingle | Michael L. Kueht Laxmi Priya Dongur Matthew Cusick Heather L. Stevenson Muhammad Mujtaba The Current State of Donor-Derived Cell-Free DNA Use in Allograft Monitoring in Kidney Transplantation Journal of Personalized Medicine renal transplantation T-cell mediated rejection antibody-mediated rejection do-nor-derived cell-free DNA |
| title | The Current State of Donor-Derived Cell-Free DNA Use in Allograft Monitoring in Kidney Transplantation |
| title_full | The Current State of Donor-Derived Cell-Free DNA Use in Allograft Monitoring in Kidney Transplantation |
| title_fullStr | The Current State of Donor-Derived Cell-Free DNA Use in Allograft Monitoring in Kidney Transplantation |
| title_full_unstemmed | The Current State of Donor-Derived Cell-Free DNA Use in Allograft Monitoring in Kidney Transplantation |
| title_short | The Current State of Donor-Derived Cell-Free DNA Use in Allograft Monitoring in Kidney Transplantation |
| title_sort | current state of donor derived cell free dna use in allograft monitoring in kidney transplantation |
| topic | renal transplantation T-cell mediated rejection antibody-mediated rejection do-nor-derived cell-free DNA |
| url | https://www.mdpi.com/2075-4426/12/10/1700 |
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