Amnion signals are essential for mesoderm formation in primates
Human and murine embryonic development has disparities, highlighting the need for primate systems. Here, the authors construct a post-implantation transcriptional atlas from non-human primate embryos and show ISL1 controls a gene regulatory network in the amnion required for mesoderm formation.
Bibliographic Details
| Main Authors: |
Ran Yang,
Alexander Goedel,
Yu Kang,
Chenyang Si,
Chu Chu,
Yi Zheng,
Zhenzhen Chen,
Peter J. Gruber,
Yao Xiao,
Chikai Zhou,
Nevin Witman,
Elif Eroglu,
Chuen-Yan Leung,
Yongchang Chen,
Jianping Fu,
Weizhi Ji,
Fredrik Lanner,
Yuyu Niu,
Kenneth R. Chien |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-08-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-25186-2
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