Cerebral electrometabolic coupling in disordered and normal states of consciousness
Summary: We assess cerebral integrity with cortical and subcortical FDG-PET and cortical electroencephalography (EEG) within the mesocircuit model framework in patients with disorders of consciousness (DoCs). The mesocircuit hypothesis proposes that subcortical activation facilitates cortical functi...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723008653 |
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| author | Jitka Annen Gianluca Frasso Glenn J.M. van der Lande Estelle A.C. Bonin Marie M. Vitello Rajanikant Panda Arianna Sala Carlo Cavaliere Federico Raimondo Mohamed Ali Bahri Nicholas D. Schiff Olivia Gosseries Aurore Thibaut Steven Laureys |
| author_facet | Jitka Annen Gianluca Frasso Glenn J.M. van der Lande Estelle A.C. Bonin Marie M. Vitello Rajanikant Panda Arianna Sala Carlo Cavaliere Federico Raimondo Mohamed Ali Bahri Nicholas D. Schiff Olivia Gosseries Aurore Thibaut Steven Laureys |
| author_sort | Jitka Annen |
| collection | DOAJ |
| description | Summary: We assess cerebral integrity with cortical and subcortical FDG-PET and cortical electroencephalography (EEG) within the mesocircuit model framework in patients with disorders of consciousness (DoCs). The mesocircuit hypothesis proposes that subcortical activation facilitates cortical function. We find that the metabolic balance of subcortical mesocircuit areas is informative for diagnosis and is associated with four EEG-based power spectral density patterns, cortical metabolism, and α power in healthy controls and patients with a DoC. Last, regional electrometabolic coupling at the cortical level can be identified in the θ and α ranges, showing positive and negative relations with glucose uptake, respectively. This relation is inverted in patients with a DoC, potentially related to altered orchestration of neural activity, and may underlie suboptimal excitability states in patients with a DoC. By understanding the neurobiological basis of the pathophysiology underlying DoCs, we foresee translational value for diagnosis and treatment of patients with a DoC. |
| first_indexed | 2024-03-12T11:53:47Z |
| format | Article |
| id | doaj.art-7dcd3ed8d7054d5b8622a08446c2e0f5 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-12T11:53:47Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-7dcd3ed8d7054d5b8622a08446c2e0f52023-08-31T05:01:54ZengElsevierCell Reports2211-12472023-08-01428112854Cerebral electrometabolic coupling in disordered and normal states of consciousnessJitka Annen0Gianluca Frasso1Glenn J.M. van der Lande2Estelle A.C. Bonin3Marie M. Vitello4Rajanikant Panda5Arianna Sala6Carlo Cavaliere7Federico Raimondo8Mohamed Ali Bahri9Nicholas D. Schiff10Olivia Gosseries11Aurore Thibaut12Steven Laureys13Coma Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau2, University Hospital of Liège, Liège, Belgium; Corresponding authorEnergy Efficiency, Samotics Bv, Leiden, the NetherlandsComa Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau2, University Hospital of Liège, Liège, BelgiumComa Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau2, University Hospital of Liège, Liège, BelgiumComa Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau2, University Hospital of Liège, Liège, BelgiumComa Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau2, University Hospital of Liège, Liège, BelgiumComa Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau2, University Hospital of Liège, Liège, BelgiumIRCCS SYNLAB SDN of Naples, Naples, ItalyComa Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium; Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, GermanyGIGA-Cyclotron Research Centre-In Vivo Imaging, University of Liège, Liège, BelgiumBMRI, Weill Cornell Medicine, New York, NY, USAComa Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau2, University Hospital of Liège, Liège, BelgiumComa Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau2, University Hospital of Liège, Liège, BelgiumComa Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau2, University Hospital of Liège, Liège, Belgium; Joint International Research Unit on Consciousness, CERVO Brain Research Centre, University Laval, Quebec City, QC, CanadaSummary: We assess cerebral integrity with cortical and subcortical FDG-PET and cortical electroencephalography (EEG) within the mesocircuit model framework in patients with disorders of consciousness (DoCs). The mesocircuit hypothesis proposes that subcortical activation facilitates cortical function. We find that the metabolic balance of subcortical mesocircuit areas is informative for diagnosis and is associated with four EEG-based power spectral density patterns, cortical metabolism, and α power in healthy controls and patients with a DoC. Last, regional electrometabolic coupling at the cortical level can be identified in the θ and α ranges, showing positive and negative relations with glucose uptake, respectively. This relation is inverted in patients with a DoC, potentially related to altered orchestration of neural activity, and may underlie suboptimal excitability states in patients with a DoC. By understanding the neurobiological basis of the pathophysiology underlying DoCs, we foresee translational value for diagnosis and treatment of patients with a DoC.http://www.sciencedirect.com/science/article/pii/S2211124723008653CP: Neuroscience |
| spellingShingle | Jitka Annen Gianluca Frasso Glenn J.M. van der Lande Estelle A.C. Bonin Marie M. Vitello Rajanikant Panda Arianna Sala Carlo Cavaliere Federico Raimondo Mohamed Ali Bahri Nicholas D. Schiff Olivia Gosseries Aurore Thibaut Steven Laureys Cerebral electrometabolic coupling in disordered and normal states of consciousness Cell Reports CP: Neuroscience |
| title | Cerebral electrometabolic coupling in disordered and normal states of consciousness |
| title_full | Cerebral electrometabolic coupling in disordered and normal states of consciousness |
| title_fullStr | Cerebral electrometabolic coupling in disordered and normal states of consciousness |
| title_full_unstemmed | Cerebral electrometabolic coupling in disordered and normal states of consciousness |
| title_short | Cerebral electrometabolic coupling in disordered and normal states of consciousness |
| title_sort | cerebral electrometabolic coupling in disordered and normal states of consciousness |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723008653 |
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