Comparative evaluation of anesthetic efficacy and hemodynamic effects of intrathecal isobaric bupivacaine versus intrathecal isobaric levobupivacaine in the lower abdominal and lower limb surgeries
Background: The most frequently utilized approach in patients undergoing lower abdominal and lower limb procedures is spinal anesthesia with bupivacaine. Aims and Objectives: The aim of the study was to compare the anesthetic efficacy and hemodynamic effects of isobaric bupivacaine and isobaric l...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2022-09-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/46975 |
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| author | Chinthavali Sujatha Chandraleela Sundararajan Arthi Asokan |
| author_facet | Chinthavali Sujatha Chandraleela Sundararajan Arthi Asokan |
| author_sort | Chinthavali Sujatha |
| collection | DOAJ |
| description | Background: The most frequently utilized approach in patients undergoing lower abdominal and lower limb procedures is spinal anesthesia with bupivacaine.
Aims and Objectives: The aim of the study was to compare the anesthetic efficacy and hemodynamic effects of isobaric bupivacaine and isobaric levobupivacaine for spinal anesthesia.
Materials and Methods: In our study, 80 patients (43 – male and 37 – female) between the ages of 18 and 70 years at Sri Venkateswaraa Medical College Hospital and Research Centre, Ariyur, Puducherry, were enrolled and split into Group I and Group II following approval by an ethical committee and written informed consent. Individuals in Group I were given 3 mL of preservative free 0.5% isobaric bupivacaine (Anawin™, bupivacaine hydrochloride, Neon laboratories, India), and Group II patients were given 3 mL of 0.5% isobaric levobupivacaine (Levoanawin™, levobupivacaine hydrochloride, Neon laboratories, India) for spinal anesthesia. A complete preanesthetic checkup was performed the day before surgery.
Results: In this study, we observed no significant correlation between height, weight, and surgery duration. We discovered a statistically substantial distinction in motor and sensory blockade between the bupivacaine (Group I) and levobupivacaine (Group II) groups. In this study, Group I (50% of patients) had a lower occurrence of hypotension than Group II (20% of patients), indicating a statistically significant variation between the groups.
Conclusion: When compared to levobupivacaine, individuals in the bupivacaine group required more administration of the vasoactive medicine ephedrine and the sympathomimetic drug atropine. Levobupivacaine is less cardiotoxic, neurotoxic, and equally potent local anesthetic compared to its racemate. |
| first_indexed | 2024-04-14T05:24:25Z |
| format | Article |
| id | doaj.art-7dcdcf666ad14d33827b1e69558241d1 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-04-14T05:24:25Z |
| publishDate | 2022-09-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-7dcdcf666ad14d33827b1e69558241d12022-12-22T02:10:02ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762022-09-011395762https://doi.org/10.3126/ajms.v13i9.46975Comparative evaluation of anesthetic efficacy and hemodynamic effects of intrathecal isobaric bupivacaine versus intrathecal isobaric levobupivacaine in the lower abdominal and lower limb surgeriesChinthavali Sujatha 0https://orcid.org/0000-0002-8003-3544Chandraleela Sundararajan 1Arthi Asokan 2https://orcid.org/0000-0002-8928-7065Assistant Professor, Department of Anaesthesiology, Sri Venkateswaraa Medical College Hospital and Research Centre, Ariyur, Puducherry, India Assistant Professor, Department of Anaesthesiology, Sri Venkateswaraa Medical College Hospital and Research Centre, Ariyur, Puducherry, IndiaAssociate Professor, Department of Anaesthesiology, Sri Venkateswaraa Medical College Hospital and Research Centre, Ariyur, Puducherry, India Background: The most frequently utilized approach in patients undergoing lower abdominal and lower limb procedures is spinal anesthesia with bupivacaine. Aims and Objectives: The aim of the study was to compare the anesthetic efficacy and hemodynamic effects of isobaric bupivacaine and isobaric levobupivacaine for spinal anesthesia. Materials and Methods: In our study, 80 patients (43 – male and 37 – female) between the ages of 18 and 70 years at Sri Venkateswaraa Medical College Hospital and Research Centre, Ariyur, Puducherry, were enrolled and split into Group I and Group II following approval by an ethical committee and written informed consent. Individuals in Group I were given 3 mL of preservative free 0.5% isobaric bupivacaine (Anawin™, bupivacaine hydrochloride, Neon laboratories, India), and Group II patients were given 3 mL of 0.5% isobaric levobupivacaine (Levoanawin™, levobupivacaine hydrochloride, Neon laboratories, India) for spinal anesthesia. A complete preanesthetic checkup was performed the day before surgery. Results: In this study, we observed no significant correlation between height, weight, and surgery duration. We discovered a statistically substantial distinction in motor and sensory blockade between the bupivacaine (Group I) and levobupivacaine (Group II) groups. In this study, Group I (50% of patients) had a lower occurrence of hypotension than Group II (20% of patients), indicating a statistically significant variation between the groups. Conclusion: When compared to levobupivacaine, individuals in the bupivacaine group required more administration of the vasoactive medicine ephedrine and the sympathomimetic drug atropine. Levobupivacaine is less cardiotoxic, neurotoxic, and equally potent local anesthetic compared to its racemate.https://www.nepjol.info/index.php/AJMS/article/view/46975spinal anesthesia; bupivacaine; levobupivacaine |
| spellingShingle | Chinthavali Sujatha Chandraleela Sundararajan Arthi Asokan Comparative evaluation of anesthetic efficacy and hemodynamic effects of intrathecal isobaric bupivacaine versus intrathecal isobaric levobupivacaine in the lower abdominal and lower limb surgeries Asian Journal of Medical Sciences spinal anesthesia; bupivacaine; levobupivacaine |
| title | Comparative evaluation of anesthetic efficacy and hemodynamic effects of intrathecal isobaric bupivacaine versus intrathecal isobaric levobupivacaine in the lower abdominal and lower limb surgeries |
| title_full | Comparative evaluation of anesthetic efficacy and hemodynamic effects of intrathecal isobaric bupivacaine versus intrathecal isobaric levobupivacaine in the lower abdominal and lower limb surgeries |
| title_fullStr | Comparative evaluation of anesthetic efficacy and hemodynamic effects of intrathecal isobaric bupivacaine versus intrathecal isobaric levobupivacaine in the lower abdominal and lower limb surgeries |
| title_full_unstemmed | Comparative evaluation of anesthetic efficacy and hemodynamic effects of intrathecal isobaric bupivacaine versus intrathecal isobaric levobupivacaine in the lower abdominal and lower limb surgeries |
| title_short | Comparative evaluation of anesthetic efficacy and hemodynamic effects of intrathecal isobaric bupivacaine versus intrathecal isobaric levobupivacaine in the lower abdominal and lower limb surgeries |
| title_sort | comparative evaluation of anesthetic efficacy and hemodynamic effects of intrathecal isobaric bupivacaine versus intrathecal isobaric levobupivacaine in the lower abdominal and lower limb surgeries |
| topic | spinal anesthesia; bupivacaine; levobupivacaine |
| url | https://www.nepjol.info/index.php/AJMS/article/view/46975 |
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