Investigation of Gas Hold up and Power Consumption in a Stirred Tank Bioreactor Using Single and Dual Impeller Configurations
A laboratory stirred tank bioreactor with six single and dual-impeller configurations was tested to obtain the optimum operating conditions for future biological processes. Six impeller combinations consisting of three basic impeller types, namely Rushton turbine (RT), pitched 4blade (P4B) and pitch...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2015-10-01
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| Series: | International Journal of Occupational Hygiene |
| Subjects: | |
| Online Access: | https://ijoh.tums.ac.ir/index.php/ijoh/article/view/76 |
| _version_ | 1831649424690905088 |
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| author | ALI KARIMI FARIDEH GOLBABAEI MOHAMMADREZA MEHRNIA KAZEM MOHAMMAD MASOUD NEGHAB AHMAD NIKPEY MOHAMMADREZA POURMAND |
| author_facet | ALI KARIMI FARIDEH GOLBABAEI MOHAMMADREZA MEHRNIA KAZEM MOHAMMAD MASOUD NEGHAB AHMAD NIKPEY MOHAMMADREZA POURMAND |
| author_sort | ALI KARIMI |
| collection | DOAJ |
| description | A laboratory stirred tank bioreactor with six single and dual-impeller configurations was tested to obtain the optimum operating conditions for future biological processes. Six impeller combinations consisting of three basic impeller types, namely Rushton turbine (RT), pitched 4blade (P4B) and pitched 2blade (P2B) downward flow were investigated in 1.77 L bioreactor working volume. Power consumption and gas hold-up measurements were taken over a range of 100-1000 rpm of stirring speed and 1-5 Lmin-1 of air flowrates, for all the six combinations consisting of any single and dual impellers. Using predicted data some empirical correlations were derived which present relations in estimation of power consumption in stirred tanks with various impeller configurations. Electrical measurement method was use to determine the power drown in the stirred bioreactor. Gas hold-up increased with an increase in stirring speed and superficial gas velocity for all the impellers employed. The number and type of impellers in stirred bioreactor had considerable influence on gas hold-up behavior of the stirred bioreactor. Besides, Rushton turbine-dual Impeller gave comparably maximum gas hold-up, but at significantly higher power consumption levels. The proposed correlations offered good agreement with theexperimental data. |
| first_indexed | 2024-12-19T14:50:31Z |
| format | Article |
| id | doaj.art-7dce14bc8ae241088d236713fdf62e3f |
| institution | Directory Open Access Journal |
| issn | 2008-5109 2008-5435 |
| language | English |
| last_indexed | 2024-12-19T14:50:31Z |
| publishDate | 2015-10-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | International Journal of Occupational Hygiene |
| spelling | doaj.art-7dce14bc8ae241088d236713fdf62e3f2022-12-21T20:16:51ZengTehran University of Medical SciencesInternational Journal of Occupational Hygiene2008-51092008-54352015-10-015376Investigation of Gas Hold up and Power Consumption in a Stirred Tank Bioreactor Using Single and Dual Impeller ConfigurationsALI KARIMI0FARIDEH GOLBABAEI1MOHAMMADREZA MEHRNIA2KAZEM MOHAMMAD3MASOUD NEGHAB4AHMAD NIKPEY5MOHAMMADREZA POURMAND6Occupational Health Department, School of Public Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran AND Occupational Health Eng. Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.Occupational Health Eng. Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.Biotechnology Group, School of Chemical Engineering, University College of Engineering, University of Tehran, Tehran, Iran.Epidemiology and Biostatistics Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.Occupational Health Department, School of Public Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran.Occupational Health Department, School of Public Health, Qazvin University of Medical Sciences, Qazvin, Iran.Pathobiology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.A laboratory stirred tank bioreactor with six single and dual-impeller configurations was tested to obtain the optimum operating conditions for future biological processes. Six impeller combinations consisting of three basic impeller types, namely Rushton turbine (RT), pitched 4blade (P4B) and pitched 2blade (P2B) downward flow were investigated in 1.77 L bioreactor working volume. Power consumption and gas hold-up measurements were taken over a range of 100-1000 rpm of stirring speed and 1-5 Lmin-1 of air flowrates, for all the six combinations consisting of any single and dual impellers. Using predicted data some empirical correlations were derived which present relations in estimation of power consumption in stirred tanks with various impeller configurations. Electrical measurement method was use to determine the power drown in the stirred bioreactor. Gas hold-up increased with an increase in stirring speed and superficial gas velocity for all the impellers employed. The number and type of impellers in stirred bioreactor had considerable influence on gas hold-up behavior of the stirred bioreactor. Besides, Rushton turbine-dual Impeller gave comparably maximum gas hold-up, but at significantly higher power consumption levels. The proposed correlations offered good agreement with theexperimental data.https://ijoh.tums.ac.ir/index.php/ijoh/article/view/76Gas hold-upStirred bioreactorPower consumptionDual-impeller |
| spellingShingle | ALI KARIMI FARIDEH GOLBABAEI MOHAMMADREZA MEHRNIA KAZEM MOHAMMAD MASOUD NEGHAB AHMAD NIKPEY MOHAMMADREZA POURMAND Investigation of Gas Hold up and Power Consumption in a Stirred Tank Bioreactor Using Single and Dual Impeller Configurations International Journal of Occupational Hygiene Gas hold-up Stirred bioreactor Power consumption Dual-impeller |
| title | Investigation of Gas Hold up and Power Consumption in a Stirred Tank Bioreactor Using Single and Dual Impeller Configurations |
| title_full | Investigation of Gas Hold up and Power Consumption in a Stirred Tank Bioreactor Using Single and Dual Impeller Configurations |
| title_fullStr | Investigation of Gas Hold up and Power Consumption in a Stirred Tank Bioreactor Using Single and Dual Impeller Configurations |
| title_full_unstemmed | Investigation of Gas Hold up and Power Consumption in a Stirred Tank Bioreactor Using Single and Dual Impeller Configurations |
| title_short | Investigation of Gas Hold up and Power Consumption in a Stirred Tank Bioreactor Using Single and Dual Impeller Configurations |
| title_sort | investigation of gas hold up and power consumption in a stirred tank bioreactor using single and dual impeller configurations |
| topic | Gas hold-up Stirred bioreactor Power consumption Dual-impeller |
| url | https://ijoh.tums.ac.ir/index.php/ijoh/article/view/76 |
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