Lack of Relationship between Fibrosis-Related Biomarkers and Cardiac Magnetic Resonance-Assessed Replacement and Interstitial Fibrosis in Dilated Cardiomyopathy
The relationship between circulating fibrosis-related molecules and magnetic resonance-assessed cardiac fibrosis in dilated cardiomyopathy (DCM) is poorly understood. To compare circulating biomarkers between DCM patients with high and low fibrosis burdens, we performed a prospective, single-center,...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/6/1295 |
| _version_ | 1827691708148613120 |
|---|---|
| author | Paweł Rubiś Ewa Dziewięcka Magdalena Szymańska Robert Banyś Małgorzata Urbańczyk-Zawadzka Maciej Krupiński Małgorzata Mielnik Sylwia Wiśniowska-Śmiałek Aleksandra Karabinowska Piotr Podolec Mateusz Winiarczyk Matylda Gliniak Monika Kaciczak Jan Robak Arman Karapetyan Ewa Wypasek |
| author_facet | Paweł Rubiś Ewa Dziewięcka Magdalena Szymańska Robert Banyś Małgorzata Urbańczyk-Zawadzka Maciej Krupiński Małgorzata Mielnik Sylwia Wiśniowska-Śmiałek Aleksandra Karabinowska Piotr Podolec Mateusz Winiarczyk Matylda Gliniak Monika Kaciczak Jan Robak Arman Karapetyan Ewa Wypasek |
| author_sort | Paweł Rubiś |
| collection | DOAJ |
| description | The relationship between circulating fibrosis-related molecules and magnetic resonance-assessed cardiac fibrosis in dilated cardiomyopathy (DCM) is poorly understood. To compare circulating biomarkers between DCM patients with high and low fibrosis burdens, we performed a prospective, single-center, observational study. The study population was composed of 100 DCM patients (87 male, mean age 45.2 ± 11.8 years, mean ejection fraction 29.7% ± 10.1%). Replacement fibrosis was quantified by means of late gadolinium enhancement (LGE), whereas interstitial fibrosis was assessed via extracellular volume (ECV). Plasma concentrations of cardiotrophin-1, growth differentiation factor-15, platelet-derived growth factor, procollagen I C-terminal propeptide, procollagen III N-terminal propeptide, and C-terminal telopeptide of type I collagen were measured. There were 44% patients with LGE and the median ECV was 27.7%. None of analyzed fibrosis serum biomarkers were associated with the LGE or ECV, whereas NT-proBNP was independently associated with both LGE and ECV, and troponin T was associated with ECV. None of the circulating fibrosis markers differentiated between DCM patients with and without replacement fibrosis, or patients stratified according to median ECV. However, cardiac-specific markers, such as NT-proBNP and hs-TnT, were associated with fibrosis. Levels of circulating markers of fibrosis seem to have no utility in the diagnosis and monitoring of cardiac fibrosis in DCM. |
| first_indexed | 2024-03-10T11:07:26Z |
| format | Article |
| id | doaj.art-7dd31ea3be2144dea2fad815f26d079a |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T11:07:26Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-7dd31ea3be2144dea2fad815f26d079a2023-11-21T21:01:05ZengMDPI AGCells2073-44092021-05-01106129510.3390/cells10061295Lack of Relationship between Fibrosis-Related Biomarkers and Cardiac Magnetic Resonance-Assessed Replacement and Interstitial Fibrosis in Dilated CardiomyopathyPaweł Rubiś0Ewa Dziewięcka1Magdalena Szymańska2Robert Banyś3Małgorzata Urbańczyk-Zawadzka4Maciej Krupiński5Małgorzata Mielnik6Sylwia Wiśniowska-Śmiałek7Aleksandra Karabinowska8Piotr Podolec9Mateusz Winiarczyk10Matylda Gliniak11Monika Kaciczak12Jan Robak13Arman Karapetyan14Ewa Wypasek15Department of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital, Pradnicka St. 80, 31-202 Krakow, PolandDepartment of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital, Pradnicka St. 80, 31-202 Krakow, PolandDepartment of Molecular Biology, John Paul II Hospital, Prądnicka St. 80, 31-202 Krakow, PolandDepartment of Radiology, John Paul II Hospital, Pradnicka Street 80, 31-202 Krakow, PolandDepartment of Radiology, John Paul II Hospital, Pradnicka Street 80, 31-202 Krakow, PolandDepartment of Radiology, John Paul II Hospital, Pradnicka Street 80, 31-202 Krakow, PolandDepartment of Radiology, John Paul II Hospital, Pradnicka Street 80, 31-202 Krakow, PolandDepartment of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital, Pradnicka St. 80, 31-202 Krakow, PolandDepartment of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital, Pradnicka St. 80, 31-202 Krakow, PolandDepartment of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital, Pradnicka St. 80, 31-202 Krakow, PolandStudents’ Scientific Group at Department of Cardiac and Vascular Diseases, Jagiellonian University Collegium Medicum, John Paul II Hospital, 31-202 Krakow, PolandStudents’ Scientific Group at Department of Cardiac and Vascular Diseases, Jagiellonian University Collegium Medicum, John Paul II Hospital, 31-202 Krakow, PolandStudents’ Scientific Group at Department of Cardiac and Vascular Diseases, Jagiellonian University Collegium Medicum, John Paul II Hospital, 31-202 Krakow, PolandStudents’ Scientific Group at Department of Cardiac and Vascular Diseases, Jagiellonian University Collegium Medicum, John Paul II Hospital, 31-202 Krakow, PolandStudents’ Scientific Group at Department of Cardiac and Vascular Diseases, Jagiellonian University Collegium Medicum, John Paul II Hospital, 31-202 Krakow, PolandDepartment of Molecular Biology, John Paul II Hospital, Prądnicka St. 80, 31-202 Krakow, PolandThe relationship between circulating fibrosis-related molecules and magnetic resonance-assessed cardiac fibrosis in dilated cardiomyopathy (DCM) is poorly understood. To compare circulating biomarkers between DCM patients with high and low fibrosis burdens, we performed a prospective, single-center, observational study. The study population was composed of 100 DCM patients (87 male, mean age 45.2 ± 11.8 years, mean ejection fraction 29.7% ± 10.1%). Replacement fibrosis was quantified by means of late gadolinium enhancement (LGE), whereas interstitial fibrosis was assessed via extracellular volume (ECV). Plasma concentrations of cardiotrophin-1, growth differentiation factor-15, platelet-derived growth factor, procollagen I C-terminal propeptide, procollagen III N-terminal propeptide, and C-terminal telopeptide of type I collagen were measured. There were 44% patients with LGE and the median ECV was 27.7%. None of analyzed fibrosis serum biomarkers were associated with the LGE or ECV, whereas NT-proBNP was independently associated with both LGE and ECV, and troponin T was associated with ECV. None of the circulating fibrosis markers differentiated between DCM patients with and without replacement fibrosis, or patients stratified according to median ECV. However, cardiac-specific markers, such as NT-proBNP and hs-TnT, were associated with fibrosis. Levels of circulating markers of fibrosis seem to have no utility in the diagnosis and monitoring of cardiac fibrosis in DCM.https://www.mdpi.com/2073-4409/10/6/1295dilated cardiomyopathyreplacement fibrosisinterstitial fibrosisbiomarkerscollagen |
| spellingShingle | Paweł Rubiś Ewa Dziewięcka Magdalena Szymańska Robert Banyś Małgorzata Urbańczyk-Zawadzka Maciej Krupiński Małgorzata Mielnik Sylwia Wiśniowska-Śmiałek Aleksandra Karabinowska Piotr Podolec Mateusz Winiarczyk Matylda Gliniak Monika Kaciczak Jan Robak Arman Karapetyan Ewa Wypasek Lack of Relationship between Fibrosis-Related Biomarkers and Cardiac Magnetic Resonance-Assessed Replacement and Interstitial Fibrosis in Dilated Cardiomyopathy Cells dilated cardiomyopathy replacement fibrosis interstitial fibrosis biomarkers collagen |
| title | Lack of Relationship between Fibrosis-Related Biomarkers and Cardiac Magnetic Resonance-Assessed Replacement and Interstitial Fibrosis in Dilated Cardiomyopathy |
| title_full | Lack of Relationship between Fibrosis-Related Biomarkers and Cardiac Magnetic Resonance-Assessed Replacement and Interstitial Fibrosis in Dilated Cardiomyopathy |
| title_fullStr | Lack of Relationship between Fibrosis-Related Biomarkers and Cardiac Magnetic Resonance-Assessed Replacement and Interstitial Fibrosis in Dilated Cardiomyopathy |
| title_full_unstemmed | Lack of Relationship between Fibrosis-Related Biomarkers and Cardiac Magnetic Resonance-Assessed Replacement and Interstitial Fibrosis in Dilated Cardiomyopathy |
| title_short | Lack of Relationship between Fibrosis-Related Biomarkers and Cardiac Magnetic Resonance-Assessed Replacement and Interstitial Fibrosis in Dilated Cardiomyopathy |
| title_sort | lack of relationship between fibrosis related biomarkers and cardiac magnetic resonance assessed replacement and interstitial fibrosis in dilated cardiomyopathy |
| topic | dilated cardiomyopathy replacement fibrosis interstitial fibrosis biomarkers collagen |
| url | https://www.mdpi.com/2073-4409/10/6/1295 |
| work_keys_str_mv | AT pawełrubis lackofrelationshipbetweenfibrosisrelatedbiomarkersandcardiacmagneticresonanceassessedreplacementandinterstitialfibrosisindilatedcardiomyopathy AT ewadziewiecka lackofrelationshipbetweenfibrosisrelatedbiomarkersandcardiacmagneticresonanceassessedreplacementandinterstitialfibrosisindilatedcardiomyopathy AT magdalenaszymanska lackofrelationshipbetweenfibrosisrelatedbiomarkersandcardiacmagneticresonanceassessedreplacementandinterstitialfibrosisindilatedcardiomyopathy AT robertbanys lackofrelationshipbetweenfibrosisrelatedbiomarkersandcardiacmagneticresonanceassessedreplacementandinterstitialfibrosisindilatedcardiomyopathy AT małgorzataurbanczykzawadzka lackofrelationshipbetweenfibrosisrelatedbiomarkersandcardiacmagneticresonanceassessedreplacementandinterstitialfibrosisindilatedcardiomyopathy AT maciejkrupinski lackofrelationshipbetweenfibrosisrelatedbiomarkersandcardiacmagneticresonanceassessedreplacementandinterstitialfibrosisindilatedcardiomyopathy AT małgorzatamielnik lackofrelationshipbetweenfibrosisrelatedbiomarkersandcardiacmagneticresonanceassessedreplacementandinterstitialfibrosisindilatedcardiomyopathy AT sylwiawisniowskasmiałek lackofrelationshipbetweenfibrosisrelatedbiomarkersandcardiacmagneticresonanceassessedreplacementandinterstitialfibrosisindilatedcardiomyopathy AT aleksandrakarabinowska lackofrelationshipbetweenfibrosisrelatedbiomarkersandcardiacmagneticresonanceassessedreplacementandinterstitialfibrosisindilatedcardiomyopathy AT piotrpodolec lackofrelationshipbetweenfibrosisrelatedbiomarkersandcardiacmagneticresonanceassessedreplacementandinterstitialfibrosisindilatedcardiomyopathy AT mateuszwiniarczyk lackofrelationshipbetweenfibrosisrelatedbiomarkersandcardiacmagneticresonanceassessedreplacementandinterstitialfibrosisindilatedcardiomyopathy AT matyldagliniak lackofrelationshipbetweenfibrosisrelatedbiomarkersandcardiacmagneticresonanceassessedreplacementandinterstitialfibrosisindilatedcardiomyopathy AT monikakaciczak lackofrelationshipbetweenfibrosisrelatedbiomarkersandcardiacmagneticresonanceassessedreplacementandinterstitialfibrosisindilatedcardiomyopathy AT janrobak lackofrelationshipbetweenfibrosisrelatedbiomarkersandcardiacmagneticresonanceassessedreplacementandinterstitialfibrosisindilatedcardiomyopathy AT armankarapetyan lackofrelationshipbetweenfibrosisrelatedbiomarkersandcardiacmagneticresonanceassessedreplacementandinterstitialfibrosisindilatedcardiomyopathy AT ewawypasek lackofrelationshipbetweenfibrosisrelatedbiomarkersandcardiacmagneticresonanceassessedreplacementandinterstitialfibrosisindilatedcardiomyopathy |