One-Step Generation of Multiple Gene-Edited Pigs by Electroporation of the CRISPR/Cas9 System into Zygotes to Reduce Xenoantigen Biosynthesis

One-Step Generation of Multiple Gene-Edited Pigs by Electroporation of the CRISPR/Cas9 System into Zygotes to Reduce Xenoantigen Biosynthesis

Xenoantigens cause hyperacute rejection and limit the success of interspecific xenografts. Therefore, genes involved in xenoantigen biosynthesis, such as <i>GGTA1</i>, <i>CMAH</i>, and <i>B4GALNT2</i>, are key targets to improve the outcomes of xenotransplantation...

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Bibliographic Details
Main Authors: Fuminori Tanihara, Maki Hirata, Nhien Thi Nguyen, Osamu Sawamoto, Takeshi Kikuchi, Takeshige Otoi
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
CRISPR/Cas9
<i>GGTA1</i>
<i>CMAH</i>
<i>B4GALNT2</i>
pig
in vitro fertilization
Online Access:https://www.mdpi.com/1422-0067/22/5/2249

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