Auxin-regulated chromatin switch directs acquisition of flower primordium founder fate
Reprogramming of cell identities during development frequently requires changes in the chromatin state that need to be restricted to the correct cell populations. Here we identify an auxin hormone-regulated chromatin state switch that directs reprogramming from transit amplifying to primordium found...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2015-10-01
|
| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/09269 |
| _version_ | 1811200368923639808 |
|---|---|
| author | Miin-Feng Wu Nobutoshi Yamaguchi Jun Xiao Bastiaan Bargmann Mark Estelle Yi Sang Doris Wagner |
| author_facet | Miin-Feng Wu Nobutoshi Yamaguchi Jun Xiao Bastiaan Bargmann Mark Estelle Yi Sang Doris Wagner |
| author_sort | Miin-Feng Wu |
| collection | DOAJ |
| description | Reprogramming of cell identities during development frequently requires changes in the chromatin state that need to be restricted to the correct cell populations. Here we identify an auxin hormone-regulated chromatin state switch that directs reprogramming from transit amplifying to primordium founder cell fate in Arabidopsis inflorescences. Upon auxin sensing, the MONOPTEROS transcription factor recruits SWI/SNF chromatin remodeling ATPases to increase accessibility of the DNA for induction of key regulators of flower primordium initiation. In the absence of the hormonal cue, auxin sensitive Aux/IAA proteins bound to MONOPTEROS block recruitment of the SWI/SNF chromatin remodeling ATPases in addition to recruiting a co-repressor/histone deacetylase complex. This simple and elegant hormone-mediated chromatin state switch is ideally suited for iterative flower primordium initiation and orchestrates additional auxin-regulated cell fate transitions. Our findings establish a new paradigm for nuclear response to auxin. They also provide an explanation for how this small molecule can direct diverse plant responses. |
| first_indexed | 2024-04-12T02:03:43Z |
| format | Article |
| id | doaj.art-7dd532878378475c9b34c6787ac4f028 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:03:43Z |
| publishDate | 2015-10-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-7dd532878378475c9b34c6787ac4f0282022-12-22T03:52:37ZengeLife Sciences Publications LtdeLife2050-084X2015-10-01410.7554/eLife.09269Auxin-regulated chromatin switch directs acquisition of flower primordium founder fateMiin-Feng Wu0Nobutoshi Yamaguchi1Jun Xiao2Bastiaan Bargmann3Mark Estelle4Yi Sang5Doris Wagner6Department of Biology, University of Pennsylvania, Philadelphia, United StatesDepartment of Biology, University of Pennsylvania, Philadelphia, United StatesDepartment of Biology, University of Pennsylvania, Philadelphia, United StatesSection of Cell and Developmental Biology, Howard Hughes Medical Institute, University of California, San Diego, San Diego, United StatesSection of Cell and Developmental Biology, Howard Hughes Medical Institute, University of California, San Diego, San Diego, United StatesDepartment of Biology, University of Pennsylvania, Philadelphia, United StatesDepartment of Biology, University of Pennsylvania, Philadelphia, United StatesReprogramming of cell identities during development frequently requires changes in the chromatin state that need to be restricted to the correct cell populations. Here we identify an auxin hormone-regulated chromatin state switch that directs reprogramming from transit amplifying to primordium founder cell fate in Arabidopsis inflorescences. Upon auxin sensing, the MONOPTEROS transcription factor recruits SWI/SNF chromatin remodeling ATPases to increase accessibility of the DNA for induction of key regulators of flower primordium initiation. In the absence of the hormonal cue, auxin sensitive Aux/IAA proteins bound to MONOPTEROS block recruitment of the SWI/SNF chromatin remodeling ATPases in addition to recruiting a co-repressor/histone deacetylase complex. This simple and elegant hormone-mediated chromatin state switch is ideally suited for iterative flower primordium initiation and orchestrates additional auxin-regulated cell fate transitions. Our findings establish a new paradigm for nuclear response to auxin. They also provide an explanation for how this small molecule can direct diverse plant responses.https://elifesciences.org/articles/09269auxin responseflower primordium initiationauxin response factor 5/MONOPTEROSchromatin remodelingaux/IAAarabidopsis thaliana |
| spellingShingle | Miin-Feng Wu Nobutoshi Yamaguchi Jun Xiao Bastiaan Bargmann Mark Estelle Yi Sang Doris Wagner Auxin-regulated chromatin switch directs acquisition of flower primordium founder fate eLife auxin response flower primordium initiation auxin response factor 5/MONOPTEROS chromatin remodeling aux/IAA arabidopsis thaliana |
| title | Auxin-regulated chromatin switch directs acquisition of flower primordium founder fate |
| title_full | Auxin-regulated chromatin switch directs acquisition of flower primordium founder fate |
| title_fullStr | Auxin-regulated chromatin switch directs acquisition of flower primordium founder fate |
| title_full_unstemmed | Auxin-regulated chromatin switch directs acquisition of flower primordium founder fate |
| title_short | Auxin-regulated chromatin switch directs acquisition of flower primordium founder fate |
| title_sort | auxin regulated chromatin switch directs acquisition of flower primordium founder fate |
| topic | auxin response flower primordium initiation auxin response factor 5/MONOPTEROS chromatin remodeling aux/IAA arabidopsis thaliana |
| url | https://elifesciences.org/articles/09269 |
| work_keys_str_mv | AT miinfengwu auxinregulatedchromatinswitchdirectsacquisitionofflowerprimordiumfounderfate AT nobutoshiyamaguchi auxinregulatedchromatinswitchdirectsacquisitionofflowerprimordiumfounderfate AT junxiao auxinregulatedchromatinswitchdirectsacquisitionofflowerprimordiumfounderfate AT bastiaanbargmann auxinregulatedchromatinswitchdirectsacquisitionofflowerprimordiumfounderfate AT markestelle auxinregulatedchromatinswitchdirectsacquisitionofflowerprimordiumfounderfate AT yisang auxinregulatedchromatinswitchdirectsacquisitionofflowerprimordiumfounderfate AT doriswagner auxinregulatedchromatinswitchdirectsacquisitionofflowerprimordiumfounderfate |