Roles of cell differentiation factors in preimplantation development of domestic animals
In mammalian embryos, the first visible differentiation event is the segregation of the inner cell mass (ICM) and trophectoderm (TE) during the transition from the morula to the blastocyst stage. The ICM, which is attached to the inside of the TE, develop into the fetus and extraembryonic tissues, w...
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| Format: | Article |
| Language: | English |
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The Society for Reproduction and Development
2021-04-01
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| Series: | The Journal of Reproduction and Development |
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| Online Access: | https://www.jstage.jst.go.jp/article/jrd/67/3/67_2021-031/_pdf/-char/en |
| _version_ | 1797615728912760832 |
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| author | Ken SAWAI |
| author_facet | Ken SAWAI |
| author_sort | Ken SAWAI |
| collection | DOAJ |
| description | In mammalian embryos, the first visible differentiation event is the segregation of the inner cell mass (ICM) and trophectoderm (TE) during the transition from the morula to the blastocyst stage. The ICM, which is attached to the inside of the TE, develop into the fetus and extraembryonic tissues, while the TE, which is a single layer surrounding the fluid-filled cavity called the blastocoel, will provide extraembryonic structures such as the placenta. ICM/TE differentiation is regulated by the interaction between various transcriptional factors. However, little information is available on the segregation of the ICM and TE lineages in preimplantation embryos of domestic animals, such as cattle and pigs. This review focuses on the roles of cell differentiation factors that regulate the ICM/TE segregation of preimplantation bovine and porcine embryos. Understanding the mechanism of cell differentiation in early embryos is necessary to improve the in vitro production systems for bovine and porcine embryos. |
| first_indexed | 2024-03-11T07:30:47Z |
| format | Article |
| id | doaj.art-7dd6c8ab4fb241e29ab48681b2eed3b0 |
| institution | Directory Open Access Journal |
| issn | 0916-8818 1348-4400 |
| language | English |
| last_indexed | 2024-03-11T07:30:47Z |
| publishDate | 2021-04-01 |
| publisher | The Society for Reproduction and Development |
| record_format | Article |
| series | The Journal of Reproduction and Development |
| spelling | doaj.art-7dd6c8ab4fb241e29ab48681b2eed3b02023-11-17T07:20:43ZengThe Society for Reproduction and DevelopmentThe Journal of Reproduction and Development0916-88181348-44002021-04-0167316116510.1262/jrd.2021-031jrdRoles of cell differentiation factors in preimplantation development of domestic animalsKen SAWAI0Faculty of Agriculture, Iwate University, Iwate 020-8550, JapanIn mammalian embryos, the first visible differentiation event is the segregation of the inner cell mass (ICM) and trophectoderm (TE) during the transition from the morula to the blastocyst stage. The ICM, which is attached to the inside of the TE, develop into the fetus and extraembryonic tissues, while the TE, which is a single layer surrounding the fluid-filled cavity called the blastocoel, will provide extraembryonic structures such as the placenta. ICM/TE differentiation is regulated by the interaction between various transcriptional factors. However, little information is available on the segregation of the ICM and TE lineages in preimplantation embryos of domestic animals, such as cattle and pigs. This review focuses on the roles of cell differentiation factors that regulate the ICM/TE segregation of preimplantation bovine and porcine embryos. Understanding the mechanism of cell differentiation in early embryos is necessary to improve the in vitro production systems for bovine and porcine embryos.https://www.jstage.jst.go.jp/article/jrd/67/3/67_2021-031/_pdf/-char/encattleembryo developmentgene expressioninner cell mas (icm)/ trophectoderm (te) segregationpig |
| spellingShingle | Ken SAWAI Roles of cell differentiation factors in preimplantation development of domestic animals The Journal of Reproduction and Development cattle embryo development gene expression inner cell mas (icm)/ trophectoderm (te) segregation pig |
| title | Roles of cell differentiation factors in preimplantation development of domestic animals |
| title_full | Roles of cell differentiation factors in preimplantation development of domestic animals |
| title_fullStr | Roles of cell differentiation factors in preimplantation development of domestic animals |
| title_full_unstemmed | Roles of cell differentiation factors in preimplantation development of domestic animals |
| title_short | Roles of cell differentiation factors in preimplantation development of domestic animals |
| title_sort | roles of cell differentiation factors in preimplantation development of domestic animals |
| topic | cattle embryo development gene expression inner cell mas (icm)/ trophectoderm (te) segregation pig |
| url | https://www.jstage.jst.go.jp/article/jrd/67/3/67_2021-031/_pdf/-char/en |
| work_keys_str_mv | AT kensawai rolesofcelldifferentiationfactorsinpreimplantationdevelopmentofdomesticanimals |