Associations between vaspin rs2236242 gene polymorphism, walking time and the risk of metabolic syndrome
The associations between serum vaspin levels and metabolic or coronary artery disease (CAD) and polycystic ovary syndrome (PCOS) is under the scope of current researchers. Therefore, this adipokine can be considered as a biomarker of metabolic syndrome (MetS). The aim of the study was to analyze the...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2019-08-01
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| Series: | Balkan Journal of Medical Genetics |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/bjmg-2019-0013 |
| _version_ | 1827845247460179968 |
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| author | Suliga E Kozieł D Cieśla E Rębak D Wawszczak M Adamus-Białek W Naszydłowska E Piechowska A Głuszek S |
| author_facet | Suliga E Kozieł D Cieśla E Rębak D Wawszczak M Adamus-Białek W Naszydłowska E Piechowska A Głuszek S |
| author_sort | Suliga E |
| collection | DOAJ |
| description | The associations between serum vaspin levels and metabolic or coronary artery disease (CAD) and polycystic ovary syndrome (PCOS) is under the scope of current researchers. Therefore, this adipokine can be considered as a biomarker of metabolic syndrome (MetS). The aim of the study was to analyze the associations between the vaspin rs2236242 polymorphism and physical activity in relation to MetS and its components. The analysis involved the genetic material and clinical data of 108 individuals with MetS and 110 controls. Vaspin rs2236242 polymorphism was detected using the tetra-primer amplification-refractory mutation system polymerase chain reaction (T-ARMS PCR) method. The TA genotype of vaspin rs2236242 was associated with a greater risk of MetS and its components compared with the TT genotype. The analysis of interactions between genotype and walking time revealed that a walking time longer than 60 min./day significantly decreased the risk of MetS in the TA carriers (p = 0.007). The obtained results suggest that any unfavorable effect of the TA genotype of the vaspin rs2236242 polymorphism can be essentially reduced, or even reversed, in a case of individuals walking longer than 60 min. a day. The analysis of the interaction between vaspin rs2236242 polymorphism and walking showed that a walking time of longer than 1 hour a day significantly reduced the risk of MetS, elevated blood pressure and triglycerides concentration. |
| first_indexed | 2024-03-12T08:53:55Z |
| format | Article |
| id | doaj.art-7dd7c6b64a4c47f59378464c2f25fc7a |
| institution | Directory Open Access Journal |
| issn | 1311-0160 |
| language | English |
| last_indexed | 2024-03-12T08:53:55Z |
| publishDate | 2019-08-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Balkan Journal of Medical Genetics |
| spelling | doaj.art-7dd7c6b64a4c47f59378464c2f25fc7a2023-09-02T16:10:18ZengSciendoBalkan Journal of Medical Genetics1311-01602019-08-01221414810.2478/bjmg-2019-0013bjmg-2019-0013Associations between vaspin rs2236242 gene polymorphism, walking time and the risk of metabolic syndromeSuliga E0Kozieł D1Cieśla E2Rębak D3Wawszczak M4Adamus-Białek W5Naszydłowska E6Piechowska A7Głuszek S8Department of Nutrition and Dietetics, Institute of Public Health, Faculty of Medicine and Health Sciences, Jan Kochanowski University, Kielce, PolandDepartment of Surgery and Surgical Nursery with Genetics Laboratory and Research Laboratory, Institute of Medical Sciences, Jan Kochanowski University, Kielce, PolandDepartment of Developmental Age Research, Institute of Public Health, Faculty of Medicine and Health Sciences, Jan Kochanowski University, Kielce, PolandDepartment of Surgery and Surgical Nursery with Genetics Laboratory and Research Laboratory, Institute of Medical Sciences, Jan Kochanowski University, Kielce, PolandDepartment of Surgery and Surgical Nursery with Genetics Laboratory and Research Laboratory, Institute of Medical Sciences, Jan Kochanowski University, Kielce, PolandDepartment of Surgery and Surgical Nursery with Genetics Laboratory and Research Laboratory, Institute of Medical Sciences, Jan Kochanowski University, Kielce, PolandDepartment of Social Prevention, Institute of Public Health, Faculty of Medicine and Health Sciences, Jan Kochanowski University, Kielce, PolandDepartment of Surgery and Surgical Nursery with Genetics Laboratory and Research Laboratory, Institute of Medical Sciences, Jan Kochanowski University, Kielce, PolandDepartment of Surgery and Surgical Nursery with Genetics Laboratory and Research Laboratory, Institute of Medical Sciences, Jan Kochanowski University, Kielce, PolandThe associations between serum vaspin levels and metabolic or coronary artery disease (CAD) and polycystic ovary syndrome (PCOS) is under the scope of current researchers. Therefore, this adipokine can be considered as a biomarker of metabolic syndrome (MetS). The aim of the study was to analyze the associations between the vaspin rs2236242 polymorphism and physical activity in relation to MetS and its components. The analysis involved the genetic material and clinical data of 108 individuals with MetS and 110 controls. Vaspin rs2236242 polymorphism was detected using the tetra-primer amplification-refractory mutation system polymerase chain reaction (T-ARMS PCR) method. The TA genotype of vaspin rs2236242 was associated with a greater risk of MetS and its components compared with the TT genotype. The analysis of interactions between genotype and walking time revealed that a walking time longer than 60 min./day significantly decreased the risk of MetS in the TA carriers (p = 0.007). The obtained results suggest that any unfavorable effect of the TA genotype of the vaspin rs2236242 polymorphism can be essentially reduced, or even reversed, in a case of individuals walking longer than 60 min. a day. The analysis of the interaction between vaspin rs2236242 polymorphism and walking showed that a walking time of longer than 1 hour a day significantly reduced the risk of MetS, elevated blood pressure and triglycerides concentration.https://doi.org/10.2478/bjmg-2019-0013abdominaladipokinesexercisemetabolic syndrome (mets)obesity |
| spellingShingle | Suliga E Kozieł D Cieśla E Rębak D Wawszczak M Adamus-Białek W Naszydłowska E Piechowska A Głuszek S Associations between vaspin rs2236242 gene polymorphism, walking time and the risk of metabolic syndrome Balkan Journal of Medical Genetics abdominal adipokines exercise metabolic syndrome (mets) obesity |
| title | Associations between vaspin rs2236242 gene polymorphism, walking time and the risk of metabolic syndrome |
| title_full | Associations between vaspin rs2236242 gene polymorphism, walking time and the risk of metabolic syndrome |
| title_fullStr | Associations between vaspin rs2236242 gene polymorphism, walking time and the risk of metabolic syndrome |
| title_full_unstemmed | Associations between vaspin rs2236242 gene polymorphism, walking time and the risk of metabolic syndrome |
| title_short | Associations between vaspin rs2236242 gene polymorphism, walking time and the risk of metabolic syndrome |
| title_sort | associations between vaspin rs2236242 gene polymorphism walking time and the risk of metabolic syndrome |
| topic | abdominal adipokines exercise metabolic syndrome (mets) obesity |
| url | https://doi.org/10.2478/bjmg-2019-0013 |
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