Successful treatment with nilotinib after bosutinib-induced pulmonary arterial hypertension recurrence following dasatinib in chronic myeloid leukemia in chronic phase
A 52-year-old man was diagnosed with chronic myeloid leukemia in the chronic phase (CML-CP). He experienced bosutinib-induced pulmonary arterial hypertension (PAH) recurrence following dasatinib use. Symptoms and examination findings associated with PAH improved after bosutinib cessation. Although n...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-01-01
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| Series: | Leukemia Research Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213048922000243 |
| _version_ | 1828517179902918656 |
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| author | Ibuki Takatsuka Hiroya Hirata Takumi Takahashi Satoshi Dohtan Shinichiro Oka Nami Sakamoto Masamitsu Takaba Miwa Adachi Tomonari Takemura Yasuyuki Nagata Takaaki Ono |
| author_facet | Ibuki Takatsuka Hiroya Hirata Takumi Takahashi Satoshi Dohtan Shinichiro Oka Nami Sakamoto Masamitsu Takaba Miwa Adachi Tomonari Takemura Yasuyuki Nagata Takaaki Ono |
| author_sort | Ibuki Takatsuka |
| collection | DOAJ |
| description | A 52-year-old man was diagnosed with chronic myeloid leukemia in the chronic phase (CML-CP). He experienced bosutinib-induced pulmonary arterial hypertension (PAH) recurrence following dasatinib use. Symptoms and examination findings associated with PAH improved after bosutinib cessation. Although nilotinib was started because of the loss of response after bosutinib cessation, a deep molecular response without PAH recurrence was achieved 3 months after the initiation of nilotinib therapy. PAH recurrence after switching to bosutinib due to dasatinib-induced PAH should be closely monitored. In addition, nilotinib therapy might be an effective approach in PAH cases related to dasatinib and/or bosutinib in patients with CML-CP. |
| first_indexed | 2024-12-11T18:37:20Z |
| format | Article |
| id | doaj.art-7dd83824e9494a509194654d4ebfeee9 |
| institution | Directory Open Access Journal |
| issn | 2213-0489 |
| language | English |
| last_indexed | 2024-12-11T18:37:20Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Leukemia Research Reports |
| spelling | doaj.art-7dd83824e9494a509194654d4ebfeee92022-12-22T00:54:43ZengElsevierLeukemia Research Reports2213-04892022-01-0117100312Successful treatment with nilotinib after bosutinib-induced pulmonary arterial hypertension recurrence following dasatinib in chronic myeloid leukemia in chronic phaseIbuki Takatsuka0Hiroya Hirata1Takumi Takahashi2Satoshi Dohtan3Shinichiro Oka4Nami Sakamoto5Masamitsu Takaba6Miwa Adachi7Tomonari Takemura8Yasuyuki Nagata9Takaaki Ono10Division of Hematology, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, Hamamatsu, Shizuoka, JapanDivision of Hematology, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, Hamamatsu, Shizuoka, JapanDivision of Hematology, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, Hamamatsu, Shizuoka, JapanDivision of Hematology, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, Hamamatsu, Shizuoka, JapanDivision of Hematology, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, Hamamatsu, Shizuoka, JapanDivision of Hematology, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, Hamamatsu, Shizuoka, JapanDivision of Hematology, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, Hamamatsu, Shizuoka, JapanDivision of Hematology, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, Hamamatsu, Shizuoka, JapanDivision of Hematology, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, Hamamatsu, Shizuoka, JapanDivision of Hematology, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, Hamamatsu, Shizuoka, JapanCorresponding author at: Division of Hematology, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, Hamamatsu, Shizuoka, Japan; Division of Hematology, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, Hamamatsu, Shizuoka, JapanA 52-year-old man was diagnosed with chronic myeloid leukemia in the chronic phase (CML-CP). He experienced bosutinib-induced pulmonary arterial hypertension (PAH) recurrence following dasatinib use. Symptoms and examination findings associated with PAH improved after bosutinib cessation. Although nilotinib was started because of the loss of response after bosutinib cessation, a deep molecular response without PAH recurrence was achieved 3 months after the initiation of nilotinib therapy. PAH recurrence after switching to bosutinib due to dasatinib-induced PAH should be closely monitored. In addition, nilotinib therapy might be an effective approach in PAH cases related to dasatinib and/or bosutinib in patients with CML-CP.http://www.sciencedirect.com/science/article/pii/S2213048922000243Pulmonary arterial hypertensionDasatinibBosutinibNilotinibChronic myeloid leukemia in chronic phase |
| spellingShingle | Ibuki Takatsuka Hiroya Hirata Takumi Takahashi Satoshi Dohtan Shinichiro Oka Nami Sakamoto Masamitsu Takaba Miwa Adachi Tomonari Takemura Yasuyuki Nagata Takaaki Ono Successful treatment with nilotinib after bosutinib-induced pulmonary arterial hypertension recurrence following dasatinib in chronic myeloid leukemia in chronic phase Leukemia Research Reports Pulmonary arterial hypertension Dasatinib Bosutinib Nilotinib Chronic myeloid leukemia in chronic phase |
| title | Successful treatment with nilotinib after bosutinib-induced pulmonary arterial hypertension recurrence following dasatinib in chronic myeloid leukemia in chronic phase |
| title_full | Successful treatment with nilotinib after bosutinib-induced pulmonary arterial hypertension recurrence following dasatinib in chronic myeloid leukemia in chronic phase |
| title_fullStr | Successful treatment with nilotinib after bosutinib-induced pulmonary arterial hypertension recurrence following dasatinib in chronic myeloid leukemia in chronic phase |
| title_full_unstemmed | Successful treatment with nilotinib after bosutinib-induced pulmonary arterial hypertension recurrence following dasatinib in chronic myeloid leukemia in chronic phase |
| title_short | Successful treatment with nilotinib after bosutinib-induced pulmonary arterial hypertension recurrence following dasatinib in chronic myeloid leukemia in chronic phase |
| title_sort | successful treatment with nilotinib after bosutinib induced pulmonary arterial hypertension recurrence following dasatinib in chronic myeloid leukemia in chronic phase |
| topic | Pulmonary arterial hypertension Dasatinib Bosutinib Nilotinib Chronic myeloid leukemia in chronic phase |
| url | http://www.sciencedirect.com/science/article/pii/S2213048922000243 |
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