Diuretic activity of the bark of Eysenhardtia polystachya
The aim of this study was to evaluate the diuretic activity of Eysenhardtia polystachya bark aqueous extract at different doses in a rat model. Different doses of E. polystachya (125, 250, 500 and 750 mg/kg body weight), furosemide (4 mg/kg) and vehicle were administered per os to female rats (n=6 a...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2016-01-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/24659 |
| _version_ | 1818749736404910080 |
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| author | Saudy Saret Pablo-Pérez María Mirian Estévez-Carmona María Estela Meléndez-Camargo |
| author_facet | Saudy Saret Pablo-Pérez María Mirian Estévez-Carmona María Estela Meléndez-Camargo |
| author_sort | Saudy Saret Pablo-Pérez |
| collection | DOAJ |
| description | The aim of this study was to evaluate the diuretic activity of Eysenhardtia polystachya bark aqueous extract at different doses in a rat model. Different doses of E. polystachya (125, 250, 500 and 750 mg/kg body weight), furosemide (4 mg/kg) and vehicle were administered per os to female rats (n=6 animals per group). After 6 hours in metabolic cages, the effect on urinary flow, glomerular ?ltration rate and electrolyte balance of sodium and potassium were assessed in all animals. E. polystachya at the doses of 500 and 750 mg/kg induced diuretic activity, since markedly increased (p<0.05) the urinary flow rate, similar to that of furosemide treated group. Only the dose of 750 mg/kg produced an increment in urinary excretion of sodium but not of potassium compared with control group. These findings indicate that E. polystachya bark-induced diuretic activity, providing evidence for its folkloric use. |
| first_indexed | 2024-12-18T04:08:31Z |
| format | Article |
| id | doaj.art-7dd8c1912074408283ca7c3b5e8ef646 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-18T04:08:31Z |
| publishDate | 2016-01-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-7dd8c1912074408283ca7c3b5e8ef6462022-12-21T21:21:31ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882016-01-0111110.3329/bjp.v11i1.24659Diuretic activity of the bark of Eysenhardtia polystachyaSaudy Saret Pablo-Pérez0María Mirian Estévez-Carmona1María Estela Meléndez-Camargo2Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional (ENCB-IPN), Mexico City, 07738Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional (ENCB-IPN), Mexico City, 07738Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional (ENCB-IPN), Mexico City, 07738The aim of this study was to evaluate the diuretic activity of Eysenhardtia polystachya bark aqueous extract at different doses in a rat model. Different doses of E. polystachya (125, 250, 500 and 750 mg/kg body weight), furosemide (4 mg/kg) and vehicle were administered per os to female rats (n=6 animals per group). After 6 hours in metabolic cages, the effect on urinary flow, glomerular ?ltration rate and electrolyte balance of sodium and potassium were assessed in all animals. E. polystachya at the doses of 500 and 750 mg/kg induced diuretic activity, since markedly increased (p<0.05) the urinary flow rate, similar to that of furosemide treated group. Only the dose of 750 mg/kg produced an increment in urinary excretion of sodium but not of potassium compared with control group. These findings indicate that E. polystachya bark-induced diuretic activity, providing evidence for its folkloric use.https://www.banglajol.info/index.php/BJP/article/view/24659DiureticEysenhardtia polystachyaFurosemide |
| spellingShingle | Saudy Saret Pablo-Pérez María Mirian Estévez-Carmona María Estela Meléndez-Camargo Diuretic activity of the bark of Eysenhardtia polystachya Bangladesh Journal of Pharmacology Diuretic Eysenhardtia polystachya Furosemide |
| title | Diuretic activity of the bark of Eysenhardtia polystachya |
| title_full | Diuretic activity of the bark of Eysenhardtia polystachya |
| title_fullStr | Diuretic activity of the bark of Eysenhardtia polystachya |
| title_full_unstemmed | Diuretic activity of the bark of Eysenhardtia polystachya |
| title_short | Diuretic activity of the bark of Eysenhardtia polystachya |
| title_sort | diuretic activity of the bark of eysenhardtia polystachya |
| topic | Diuretic Eysenhardtia polystachya Furosemide |
| url | https://www.banglajol.info/index.php/BJP/article/view/24659 |
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