Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy

Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy

Abstract Background Tauopathies comprise a family of neurodegenerative disorders including Alzheimer’s disease for which there is an urgent and unmet need for disease-modifying treatments. Tauopathies are characterized by pathological tau hyperphosphorylation, which has been shown to correlate tight...

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Main Authors: Seyedeh Maryam Alavi Naini, Constantin Yanicostas, Rahma Hassan-Abdi, Sébastien Blondeel, Mohamed Bennis, Ryan J. Weiss, Yitzhak Tor, Jeffrey D. Esko, Nadia Soussi-Yanicostas
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Translational Neurodegeneration
Subjects:
Tauopathy
Zebrafish
Alzheimer’s disease
Tau protein
Tau hyperphosphorylation
Surfen
Online Access:http://link.springer.com/article/10.1186/s40035-018-0111-2

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