Systemic lupus erythematous and CD24V
Background: Systemic lupus erythematous is an autoimmune disease of multifactorial etiology with genetic predisposition. Its pathogenesis involved more than 100 genes. CD24 gene can mediate various functions such as their costimulatory activity in the clonal expansion of T cells. The single nucleoti...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Colegio Mexicano de Inmunología Clínica y Alergia, A.C.
2015-11-01
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| Series: | Revista Alergia México |
| Subjects: | |
| Online Access: | http://revistaalergia.mx/ojs/index.php/ram/article/view/76 |
| _version_ | 1797764869160697856 |
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| author | Rubén Darío Jiménez-Uscanga Margarita Carsolio-Trujano Diana Andrea Herrera-Sánchez María Isabel Castrejón-Vázquez Fedra Irazoque-Palacios María Eugenia Vargas-Camaño Nora Ernestina Martínez-Aguilar María del Carmen Chima-Galán |
| author_facet | Rubén Darío Jiménez-Uscanga Margarita Carsolio-Trujano Diana Andrea Herrera-Sánchez María Isabel Castrejón-Vázquez Fedra Irazoque-Palacios María Eugenia Vargas-Camaño Nora Ernestina Martínez-Aguilar María del Carmen Chima-Galán |
| author_sort | Rubén Darío Jiménez-Uscanga |
| collection | DOAJ |
| description | Background: Systemic lupus erythematous is an autoimmune disease of multifactorial etiology with genetic predisposition. Its pathogenesis involved more than 100 genes. CD24 gene can mediate various functions such as their costimulatory activity in the clonal expansion of T cells. The single nucleotide polymorphism, resulting in a non-conservative replacement of alanine to valine (CD24v) precedes immediately GPI anchorage site (position ω-1), determines CD24 loss activity. CD24v has been associated with multiple sclerosis and systemic lupus erythematous in other populations.
Objective: To find the presence of CD24v in Mexican patients with systemic lupus erythematous.
Material and method: A study of fenotyping of CD24v included 65 subjects, 32 cases (systemic lupus erythematous): 28 women and 4 men; and 32 controls: 9 women and 23 men; cases and controls from patients with systemic lupus erythematous in National Medical Center 20 de Noviembre ISSSTE, Mexico City, services of Clinical Immunology and Rheumatology.
Results: In cases, 19 patients had a wild homozygous genotype, 12 were heterozygous and only one patient showed homozygous polymorphism. In controls, 17 showed wild heterozygous genotypes; 14 were heterozygous and 1 was found to be polymorphic homozygote. With odds ratio: 0.84 and chi cuadrada of 0.17; therefore there was no statistically significant difference.
Conclusions: Study population showed that there is no statistically significant difference between systemic lupus erythematous cases and controls with respect to the presence of CD24v. |
| first_indexed | 2024-03-12T20:01:59Z |
| format | Article |
| id | doaj.art-7dd9baf4f8f0469cb56eaed12bf63085 |
| institution | Directory Open Access Journal |
| issn | 0002-5151 2448-9190 |
| language | English |
| last_indexed | 2024-03-12T20:01:59Z |
| publishDate | 2015-11-01 |
| publisher | Colegio Mexicano de Inmunología Clínica y Alergia, A.C. |
| record_format | Article |
| series | Revista Alergia México |
| spelling | doaj.art-7dd9baf4f8f0469cb56eaed12bf630852023-08-02T02:20:13ZengColegio Mexicano de Inmunología Clínica y Alergia, A.C.Revista Alergia México0002-51512448-91902015-11-0162426527010.29262/ram.v62i4.7696Systemic lupus erythematous and CD24VRubén Darío Jiménez-Uscanga0Margarita Carsolio-Trujano1Diana Andrea Herrera-Sánchez2María Isabel Castrejón-Vázquez3Fedra Irazoque-Palacios4María Eugenia Vargas-Camaño5Nora Ernestina Martínez-Aguilar6María del Carmen Chima-Galán7Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Centro Médico Nacional 20 de Noviembre, Servicio Inmunología Clínica y Alergia, Ciudad de MéxicoInstituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Centro Médico Nacional 20 de Noviembre, Servicio Inmunología Clínica y Alergia, Ciudad de MéxicoInstituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, Servicio de Alergia e Inmunología Clínica, Ciudad de MéxicoInstituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Centro Médico Nacional 20 de Noviembre, Servicio Inmunología Clínica y Alergia, Ciudad de MéxicoInstituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Centro Médico Nacional 20 de Noviembre, Servicio Inmunología Clínica y Alergia, Ciudad de MéxicoInstituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Centro Médico Nacional 20 de Noviembre, Servicio Inmunología Clínica y Alergia, Ciudad de MéxicoInstituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Centro Médico Nacional 20 de Noviembre, Servicio Inmunología Clínica y Alergia, Ciudad de MéxicoInstituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Centro Médico Nacional 20 de Noviembre, Servicio Inmunología Clínica y Alergia, Ciudad de MéxicoBackground: Systemic lupus erythematous is an autoimmune disease of multifactorial etiology with genetic predisposition. Its pathogenesis involved more than 100 genes. CD24 gene can mediate various functions such as their costimulatory activity in the clonal expansion of T cells. The single nucleotide polymorphism, resulting in a non-conservative replacement of alanine to valine (CD24v) precedes immediately GPI anchorage site (position ω-1), determines CD24 loss activity. CD24v has been associated with multiple sclerosis and systemic lupus erythematous in other populations. Objective: To find the presence of CD24v in Mexican patients with systemic lupus erythematous. Material and method: A study of fenotyping of CD24v included 65 subjects, 32 cases (systemic lupus erythematous): 28 women and 4 men; and 32 controls: 9 women and 23 men; cases and controls from patients with systemic lupus erythematous in National Medical Center 20 de Noviembre ISSSTE, Mexico City, services of Clinical Immunology and Rheumatology. Results: In cases, 19 patients had a wild homozygous genotype, 12 were heterozygous and only one patient showed homozygous polymorphism. In controls, 17 showed wild heterozygous genotypes; 14 were heterozygous and 1 was found to be polymorphic homozygote. With odds ratio: 0.84 and chi cuadrada of 0.17; therefore there was no statistically significant difference. Conclusions: Study population showed that there is no statistically significant difference between systemic lupus erythematous cases and controls with respect to the presence of CD24v.http://revistaalergia.mx/ojs/index.php/ram/article/view/76lupus eritematoso sistémicopolimorfismo de un simple nucleótidoCD24CD24v |
| spellingShingle | Rubén Darío Jiménez-Uscanga Margarita Carsolio-Trujano Diana Andrea Herrera-Sánchez María Isabel Castrejón-Vázquez Fedra Irazoque-Palacios María Eugenia Vargas-Camaño Nora Ernestina Martínez-Aguilar María del Carmen Chima-Galán Systemic lupus erythematous and CD24V Revista Alergia México lupus eritematoso sistémico polimorfismo de un simple nucleótido CD24 CD24v |
| title | Systemic lupus erythematous and CD24V |
| title_full | Systemic lupus erythematous and CD24V |
| title_fullStr | Systemic lupus erythematous and CD24V |
| title_full_unstemmed | Systemic lupus erythematous and CD24V |
| title_short | Systemic lupus erythematous and CD24V |
| title_sort | systemic lupus erythematous and cd24v |
| topic | lupus eritematoso sistémico polimorfismo de un simple nucleótido CD24 CD24v |
| url | http://revistaalergia.mx/ojs/index.php/ram/article/view/76 |
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