Production of l-alanyl-l-glutamine by immobilized Pichia pastoris GS115 expressing α-amino acid ester acyltransferase

Production of l-alanyl-l-glutamine by immobilized Pichia pastoris GS115 expressing α-amino acid ester acyltransferase

Abstract Background l-Alanyl-l-glutamine (Ala-Gln) represents the great application potential in clinic due to the unique physicochemical properties. A new approach was developed to synthesize Ala-Gln by recombinant Escherichia coli OPA, which could overcome the disadvantages of traditional chemical...

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Bibliographic Details
Main Authors: Yi-Min Li, Jiao-Qi Gao, Xu-Ze Pei, Cong Du, Chao Fan, Wen-Jie Yuan, Feng-Wu Bai
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Microbial Cell Factories
Subjects:
l-Alanyl-l-glutamine
α-Amino acid ester acyltransferase
Immobilization
Codon optimization
Recycle
Online Access:http://link.springer.com/article/10.1186/s12934-019-1077-1

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