Comparative Evaluation of Volatile Anaesthetic Agents for Attenuation of Venous Cannulation Pain: A Prospective, Randomized Controlled Study
Introduction: Topical application of volatile anaesthetic agents has been found to attenuate the response to a mechanical stimulus; however, this effect of volatile anaesthetic on perception of pain during venous cannulation is not known. Aim: To compare the efficacy of topically administered vo...
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JCDR Research and Publications Private Limited
2016-09-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/8412/19970_CE[Ra]_F(P)_PF1(ROAK)_PFA(AK)_PF2(PAG).pdf |
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| author | Vinit K. Srivastava Pravin K Das Sujeet KS Gautam Parineeta Jaisawal Venkat N. Kadiyala Sonal Rambhad |
| author_facet | Vinit K. Srivastava Pravin K Das Sujeet KS Gautam Parineeta Jaisawal Venkat N. Kadiyala Sonal Rambhad |
| author_sort | Vinit K. Srivastava |
| collection | DOAJ |
| description | Introduction: Topical application of volatile anaesthetic agents
has been found to attenuate the response to a mechanical
stimulus; however, this effect of volatile anaesthetic on
perception of pain during venous cannulation is not known.
Aim: To compare the efficacy of topically administered volatile
anaesthetic agents for attenuating venous cannulation pain.
Materials and Methods: This prospective, randomized,
placebo controlled and double blind study was conducted on
120 patients, aged 20-60years. They were of American Society
of Anaesthesiologists (ASA) I or II physical status, of either sex,
planned for elective surgeries. These patients were randomized
into 4 groups, of 30 each. Equipotent doses of halothane
(1ml), isoflurane (1.5ml), sevoflurane (2.7ml) and sterile water
(2.5ml; Control) were topically administered on the volar surface
of forearm wrapped with cotton and aluminium foil; venous
cannulation was performed with 18G intravenous cannula after
30 min. These patients were assessed for the incidence and
severity of pain upon venous cannulation {visual analog scale
(VAS), 0-100mm; 0 = no pain and 100 = worst imaginable pain}.
Data were analysed by one-way ANOVA, Chi-square test and
Kruskal-Wallis test. The p<0.05 was considered as significant.
Results: A significant reduction in the incidence of venous
cannulation pain was observed in the halothane (79%) group as
compared to control (100%; p<0.05), isoflurane (100%; p<0.05)
and sevoflurane (100%; p<0.05) groups. The severity of venous
cannulation pain as assessed by median (interquartile range,
Q1-Q3). VAS scores was reduced in the halothane {10 (10-20);
p<0.001}, isoflurane {20 (10-30); p<0.001} and sevoflurane {20
(20-30); p<0.001} groups as compared to the control group {40
(30-40)}; VAS score in the halothane group was significantly less
as compared to isoflurane (p<0.05) and sevoflurane (p<0.05)
groups.
Conclusion: Topical application of halothane is most effective
in reducing incidence and severity of venous cannulation pain;
however, topical application of isoflurane and sevoflurane
decreases only the severity of venous cannulation pain. |
| first_indexed | 2024-04-13T01:22:18Z |
| format | Article |
| id | doaj.art-7ddb05d199f14fe283b4e544c94153de |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-13T01:22:18Z |
| publishDate | 2016-09-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-7ddb05d199f14fe283b4e544c94153de2022-12-22T03:08:43ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-09-01109UC01UC0410.7860/JCDR/2016/19970.8412Comparative Evaluation of Volatile Anaesthetic Agents for Attenuation of Venous Cannulation Pain: A Prospective, Randomized Controlled StudyVinit K. Srivastava0Pravin K Das1Sujeet KS Gautam2Parineeta Jaisawal3Venkat N. Kadiyala4Sonal Rambhad5Senior Consultant, Department of Anaesthesiology, Apollo Hospitals, Bilaspur, Chhattisgarh, India.Associate Professor, Department of Anaesthesiology, Dr RML Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. Assistant Professor, Department of Anaesthesiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.Consultant, Department of Anaesthesiology, Apollo Hospitals, Bilaspur, Chhattisgarh, India.DNB Student, Department of Anaesthesiology, Apollo Hospitals, Bilaspur, Chhattisgarh, India. DNB Student, Department of Anaesthesiology, Apollo Hospitals, Bilaspur, Chhattisgarh, India.Introduction: Topical application of volatile anaesthetic agents has been found to attenuate the response to a mechanical stimulus; however, this effect of volatile anaesthetic on perception of pain during venous cannulation is not known. Aim: To compare the efficacy of topically administered volatile anaesthetic agents for attenuating venous cannulation pain. Materials and Methods: This prospective, randomized, placebo controlled and double blind study was conducted on 120 patients, aged 20-60years. They were of American Society of Anaesthesiologists (ASA) I or II physical status, of either sex, planned for elective surgeries. These patients were randomized into 4 groups, of 30 each. Equipotent doses of halothane (1ml), isoflurane (1.5ml), sevoflurane (2.7ml) and sterile water (2.5ml; Control) were topically administered on the volar surface of forearm wrapped with cotton and aluminium foil; venous cannulation was performed with 18G intravenous cannula after 30 min. These patients were assessed for the incidence and severity of pain upon venous cannulation {visual analog scale (VAS), 0-100mm; 0 = no pain and 100 = worst imaginable pain}. Data were analysed by one-way ANOVA, Chi-square test and Kruskal-Wallis test. The p<0.05 was considered as significant. Results: A significant reduction in the incidence of venous cannulation pain was observed in the halothane (79%) group as compared to control (100%; p<0.05), isoflurane (100%; p<0.05) and sevoflurane (100%; p<0.05) groups. The severity of venous cannulation pain as assessed by median (interquartile range, Q1-Q3). VAS scores was reduced in the halothane {10 (10-20); p<0.001}, isoflurane {20 (10-30); p<0.001} and sevoflurane {20 (20-30); p<0.001} groups as compared to the control group {40 (30-40)}; VAS score in the halothane group was significantly less as compared to isoflurane (p<0.05) and sevoflurane (p<0.05) groups. Conclusion: Topical application of halothane is most effective in reducing incidence and severity of venous cannulation pain; however, topical application of isoflurane and sevoflurane decreases only the severity of venous cannulation pain.https://jcdr.net/articles/PDF/8412/19970_CE[Ra]_F(P)_PF1(ROAK)_PFA(AK)_PF2(PAG).pdfhalothaneisofluranesevoflurane |
| spellingShingle | Vinit K. Srivastava Pravin K Das Sujeet KS Gautam Parineeta Jaisawal Venkat N. Kadiyala Sonal Rambhad Comparative Evaluation of Volatile Anaesthetic Agents for Attenuation of Venous Cannulation Pain: A Prospective, Randomized Controlled Study Journal of Clinical and Diagnostic Research halothane isoflurane sevoflurane |
| title | Comparative Evaluation of Volatile Anaesthetic Agents for Attenuation of Venous Cannulation Pain: A Prospective, Randomized Controlled Study |
| title_full | Comparative Evaluation of Volatile Anaesthetic Agents for Attenuation of Venous Cannulation Pain: A Prospective, Randomized Controlled Study |
| title_fullStr | Comparative Evaluation of Volatile Anaesthetic Agents for Attenuation of Venous Cannulation Pain: A Prospective, Randomized Controlled Study |
| title_full_unstemmed | Comparative Evaluation of Volatile Anaesthetic Agents for Attenuation of Venous Cannulation Pain: A Prospective, Randomized Controlled Study |
| title_short | Comparative Evaluation of Volatile Anaesthetic Agents for Attenuation of Venous Cannulation Pain: A Prospective, Randomized Controlled Study |
| title_sort | comparative evaluation of volatile anaesthetic agents for attenuation of venous cannulation pain a prospective randomized controlled study |
| topic | halothane isoflurane sevoflurane |
| url | https://jcdr.net/articles/PDF/8412/19970_CE[Ra]_F(P)_PF1(ROAK)_PFA(AK)_PF2(PAG).pdf |
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