The effects of chronic candesartan treatment on cardiac and hepatic adenosine monophosphate-activated protein kinase in rats submitted to surgical stress
Introduction: adenosine monophosphate-activated protein kinase (AMPK) plays a prominent role as a metabolic stress sensor, and it has recently been suggested that the renin-angiotensin system, in addition to its role in stress regulation, may play a significant role in regulating the AMPK system. Th...
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| Format: | Article |
| Language: | English |
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SAGE Publications
2015-09-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320313499199 |
| _version_ | 1797283604041039872 |
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| author | Antônio Ribeiro-Oliveira Mirna B Marques Walkiria W Vilas-Boas Jonas Guimarães Cândido C Coimbra Allan P Anjos Rodrigo B Fóscolo Robson Santos Julia D Thomas Suzana M Igreja Blerina Kola Ashley B Grossman Márta Korbonits |
| author_facet | Antônio Ribeiro-Oliveira Mirna B Marques Walkiria W Vilas-Boas Jonas Guimarães Cândido C Coimbra Allan P Anjos Rodrigo B Fóscolo Robson Santos Julia D Thomas Suzana M Igreja Blerina Kola Ashley B Grossman Márta Korbonits |
| author_sort | Antônio Ribeiro-Oliveira |
| collection | DOAJ |
| description | Introduction: adenosine monophosphate-activated protein kinase (AMPK) plays a prominent role as a metabolic stress sensor, and it has recently been suggested that the renin-angiotensin system, in addition to its role in stress regulation, may play a significant role in regulating the AMPK system. This study aimed to evaluate the effects of candesartan, an angiotensin II receptor blocker, on cardiac and hepatic AMPK activity basally as well as after surgical stress under general anesthesia. Materials and methods: Male Wistar rats were treated with 5 mg/kg/day candesartan in their drinking water for two weeks. Levels of cardiac and hepatic AMPK activity were determined, using a kinase activity assay, basally and after surgical stress under general anesthesia. Results: Chronic administration of candesartan increased hepatic AMPK activity approximately 4 times ( p <0.05) while no significant change was demonstrated in cardiac AMPK. Cardiac and hepatic AMPK activities were not significantly increased by surgical stress alone performed under anesthesia. However, chronic treatment with candesartan decreased AMPK activity in both liver and heart after surgical stress under anesthesia ( p <0.01 for both comparisons). Conclusions: While chronic candesartan treatment may stimulate AMPK activity in certain organs such as the liver, when combined with surgical stress under anesthesia it inhibits pathways regulating AMPK activity. |
| first_indexed | 2024-03-07T17:34:11Z |
| format | Article |
| id | doaj.art-7ddb39a8607e49a59e57eba834e69d61 |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T17:34:11Z |
| publishDate | 2015-09-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-7ddb39a8607e49a59e57eba834e69d612024-03-02T17:16:06ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762015-09-011610.1177/1470320313499199The effects of chronic candesartan treatment on cardiac and hepatic adenosine monophosphate-activated protein kinase in rats submitted to surgical stressAntônio Ribeiro-Oliveira0Mirna B Marques1Walkiria W Vilas-Boas2Jonas Guimarães3Cândido C Coimbra4Allan P Anjos5Rodrigo B Fóscolo6Robson Santos7Julia D Thomas8Suzana M Igreja9Blerina Kola10Ashley B Grossman11Márta Korbonits12Department of Internal Medicine, Federal University of Minas Gerais, BrazilDepartment of Endocrinology, Queen Mary University of London, UKDepartment of Surgery, Federal University of Minas Gerais, BrazilDepartment of Internal Medicine, Federal University of Minas Gerais, BrazilDepartment of Physiology and Biophysics, Federal University of Minas Gerais, BrazilDepartment of Internal Medicine, Federal University of Minas Gerais, BrazilDepartment of Internal Medicine, Federal University of Minas Gerais, BrazilDepartment of Physiology and Biophysics, Federal University of Minas Gerais, BrazilDepartment of Endocrinology, Queen Mary University of London, UKDepartment of Endocrinology, Queen Mary University of London, UKDepartment of Endocrinology, Queen Mary University of London, UKOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UKDepartment of Endocrinology, Queen Mary University of London, UKIntroduction: adenosine monophosphate-activated protein kinase (AMPK) plays a prominent role as a metabolic stress sensor, and it has recently been suggested that the renin-angiotensin system, in addition to its role in stress regulation, may play a significant role in regulating the AMPK system. This study aimed to evaluate the effects of candesartan, an angiotensin II receptor blocker, on cardiac and hepatic AMPK activity basally as well as after surgical stress under general anesthesia. Materials and methods: Male Wistar rats were treated with 5 mg/kg/day candesartan in their drinking water for two weeks. Levels of cardiac and hepatic AMPK activity were determined, using a kinase activity assay, basally and after surgical stress under general anesthesia. Results: Chronic administration of candesartan increased hepatic AMPK activity approximately 4 times ( p <0.05) while no significant change was demonstrated in cardiac AMPK. Cardiac and hepatic AMPK activities were not significantly increased by surgical stress alone performed under anesthesia. However, chronic treatment with candesartan decreased AMPK activity in both liver and heart after surgical stress under anesthesia ( p <0.01 for both comparisons). Conclusions: While chronic candesartan treatment may stimulate AMPK activity in certain organs such as the liver, when combined with surgical stress under anesthesia it inhibits pathways regulating AMPK activity.https://doi.org/10.1177/1470320313499199 |
| spellingShingle | Antônio Ribeiro-Oliveira Mirna B Marques Walkiria W Vilas-Boas Jonas Guimarães Cândido C Coimbra Allan P Anjos Rodrigo B Fóscolo Robson Santos Julia D Thomas Suzana M Igreja Blerina Kola Ashley B Grossman Márta Korbonits The effects of chronic candesartan treatment on cardiac and hepatic adenosine monophosphate-activated protein kinase in rats submitted to surgical stress Journal of the Renin-Angiotensin-Aldosterone System |
| title | The effects of chronic candesartan treatment on cardiac and hepatic adenosine monophosphate-activated protein kinase in rats submitted to surgical stress |
| title_full | The effects of chronic candesartan treatment on cardiac and hepatic adenosine monophosphate-activated protein kinase in rats submitted to surgical stress |
| title_fullStr | The effects of chronic candesartan treatment on cardiac and hepatic adenosine monophosphate-activated protein kinase in rats submitted to surgical stress |
| title_full_unstemmed | The effects of chronic candesartan treatment on cardiac and hepatic adenosine monophosphate-activated protein kinase in rats submitted to surgical stress |
| title_short | The effects of chronic candesartan treatment on cardiac and hepatic adenosine monophosphate-activated protein kinase in rats submitted to surgical stress |
| title_sort | effects of chronic candesartan treatment on cardiac and hepatic adenosine monophosphate activated protein kinase in rats submitted to surgical stress |
| url | https://doi.org/10.1177/1470320313499199 |
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