Understanding superiority, noninferiority, and equivalence for clinical trials
Randomized control trialsare the gold standard for testing the efficacy of new interventions. Historically, superiority trials were methods of choice as reference (standard) interventions were not established for many disease conditions. However currently, reference interventions are available for m...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Indian Dermatology Online Journal |
| Subjects: | |
| Online Access: | http://www.idoj.in/article.asp?issn=2229-5178;year=2020;volume=11;issue=6;spage=890;epage=894;aulast=Kishore |
| _version_ | 1818957103602073600 |
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| author | Kamal Kishore Rahul Mahajan |
| author_facet | Kamal Kishore Rahul Mahajan |
| author_sort | Kamal Kishore |
| collection | DOAJ |
| description | Randomized control trialsare the gold standard for testing the efficacy of new interventions. Historically, superiority trials were methods of choice as reference (standard) interventions were not established for many disease conditions. However currently, reference interventions are available for most of adverse conditions. Despite this, many investigators are using superiority trials in comparison to more suitable noninferiority and equivalence trials. The application of noninferiority and equivalence trials is on the rise, but by and large, these trials are poorly understood, ill-conceived, inappropriately analyzed, and reported and misinterpreted. |
| first_indexed | 2024-12-20T11:04:32Z |
| format | Article |
| id | doaj.art-7ddb6be05e5a4fe095bb5ee01d3a4351 |
| institution | Directory Open Access Journal |
| issn | 2229-5178 |
| language | English |
| last_indexed | 2024-12-20T11:04:32Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Dermatology Online Journal |
| spelling | doaj.art-7ddb6be05e5a4fe095bb5ee01d3a43512022-12-21T19:42:55ZengWolters Kluwer Medknow PublicationsIndian Dermatology Online Journal2229-51782020-01-0111689089410.4103/idoj.IDOJ_130_20Understanding superiority, noninferiority, and equivalence for clinical trialsKamal KishoreRahul MahajanRandomized control trialsare the gold standard for testing the efficacy of new interventions. Historically, superiority trials were methods of choice as reference (standard) interventions were not established for many disease conditions. However currently, reference interventions are available for most of adverse conditions. Despite this, many investigators are using superiority trials in comparison to more suitable noninferiority and equivalence trials. The application of noninferiority and equivalence trials is on the rise, but by and large, these trials are poorly understood, ill-conceived, inappropriately analyzed, and reported and misinterpreted.http://www.idoj.in/article.asp?issn=2229-5178;year=2020;volume=11;issue=6;spage=890;epage=894;aulast=Kishoreclinical trialsequivalencemethodologynoninferioritysuperiority |
| spellingShingle | Kamal Kishore Rahul Mahajan Understanding superiority, noninferiority, and equivalence for clinical trials Indian Dermatology Online Journal clinical trials equivalence methodology noninferiority superiority |
| title | Understanding superiority, noninferiority, and equivalence for clinical trials |
| title_full | Understanding superiority, noninferiority, and equivalence for clinical trials |
| title_fullStr | Understanding superiority, noninferiority, and equivalence for clinical trials |
| title_full_unstemmed | Understanding superiority, noninferiority, and equivalence for clinical trials |
| title_short | Understanding superiority, noninferiority, and equivalence for clinical trials |
| title_sort | understanding superiority noninferiority and equivalence for clinical trials |
| topic | clinical trials equivalence methodology noninferiority superiority |
| url | http://www.idoj.in/article.asp?issn=2229-5178;year=2020;volume=11;issue=6;spage=890;epage=894;aulast=Kishore |
| work_keys_str_mv | AT kamalkishore understandingsuperioritynoninferiorityandequivalenceforclinicaltrials AT rahulmahajan understandingsuperioritynoninferiorityandequivalenceforclinicaltrials |