Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype.
Visceral Leishmaniasis (VL), caused by the intracellular protozoan Leishmania donovani, is characterized by relentlessly increasing visceral parasite replication, cachexia, massive splenomegaly, pancytopenia and ultimately death. Progressive disease is considered to be due to impaired effector T cel...
Main Authors: | Fanping Kong, Omar A Saldarriaga, Heidi Spratt, E Yaneth Osorio, Bruno L Travi, Bruce A Luxon, Peter C Melby |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-01-01
|
Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC5283737?pdf=render |
Similar Items
-
Visceral leishmaniasis with multiple splenic nodular lesions
by: Lucas Mustafa Aguiar, et al. -
Malnutrition-related parasite dissemination from the skin in visceral leishmaniasis is driven by PGE2-mediated amplification of CCR7-related trafficking of infected inflammatory monocytes.
by: E Yaneth Osorio, et al.
Published: (2023-01-01) -
Hematological and Clinical Features Associated with Initial Poor Treatment Outcomes in Visceral Leishmaniasis Patients with and without HIV Coinfection in Gondar, Northwest Ethiopia
by: Muluneh Ademe, et al.
Published: (2023-01-01) -
Visceral leishmaniasis concurrent with splenic marginal zone B-cell lymphoma
by: U L Julhakyan, et al.
Published: (2016-02-01) -
Use of domperidone in canine visceral leishmaniasis: gaps in veterinary knowledge and epidemiological implications
by: Bruno L Travi, et al.
Published: (2018-10-01)