Major Characteristics of Severity and Mortality in Diabetic Patients With COVID-19 and Establishment of Severity Risk Score
Objectives: Diabetes is a risk factor for poor COVID-19 prognosis. The analysis of related prognostic factors in diabetic patients with COVID-19 would be helpful for further treatment of such patients.Methods: This retrospective study involved 3623 patients with COVID-19 (325 with diabetes). Clinica...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.655604/full |
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| author | Yu-Feng Xiao Jia-Lin He Jia-Lin He Jia-Lin He Yu Xu Yu Xu Yu Xu Xi Liu Xi Liu Xi Liu Hui Lin Qi Li Qi Li Qi Li Zhi Xu Zhi Xu Zhi Xu Ming-Dong Hu Ming-Dong Hu Ming-Dong Hu Xiao-Bao Ren Xiao-Bao Ren Xiao-Bao Ren Cheng Zhang Cheng Zhang Cheng Zhang Wen-Jing Zhang Wen-Jing Zhang Wen-Jing Zhang Wei Duan Wei Duan Wei Duan Yong-Feng Tian Yong-Feng Tian Yong-Feng Tian Ping Li Ping Li Ping Li Hao Wu Hao Wu Cai-Ping Song Cai-Ping Song Cai-Ping Song En Liu Shi-Ming Yang Shi-Ming Yang Shi-Ming Yang |
| author_facet | Yu-Feng Xiao Jia-Lin He Jia-Lin He Jia-Lin He Yu Xu Yu Xu Yu Xu Xi Liu Xi Liu Xi Liu Hui Lin Qi Li Qi Li Qi Li Zhi Xu Zhi Xu Zhi Xu Ming-Dong Hu Ming-Dong Hu Ming-Dong Hu Xiao-Bao Ren Xiao-Bao Ren Xiao-Bao Ren Cheng Zhang Cheng Zhang Cheng Zhang Wen-Jing Zhang Wen-Jing Zhang Wen-Jing Zhang Wei Duan Wei Duan Wei Duan Yong-Feng Tian Yong-Feng Tian Yong-Feng Tian Ping Li Ping Li Ping Li Hao Wu Hao Wu Cai-Ping Song Cai-Ping Song Cai-Ping Song En Liu Shi-Ming Yang Shi-Ming Yang Shi-Ming Yang |
| author_sort | Yu-Feng Xiao |
| collection | DOAJ |
| description | Objectives: Diabetes is a risk factor for poor COVID-19 prognosis. The analysis of related prognostic factors in diabetic patients with COVID-19 would be helpful for further treatment of such patients.Methods: This retrospective study involved 3623 patients with COVID-19 (325 with diabetes). Clinical characteristics and laboratory tests were collected and compared between the diabetic group and the non-diabetic group. Binary logistic regression analysis was applied to explore risk factors associated in diabetic patients with COVID-19. A prediction model was built based on these risk factors.Results: The risk factors for higher mortality in diabetic patients with COVID-19 were dyspnea, lung disease, cardiovascular diseases, neutrophil, PLT count, and CKMB. Similarly, dyspnea, cardiovascular diseases, neutrophil, PLT count, and CKMB were risk factors related to the severity of diabetes with COVID-19. Based on these factors, a risk score was built to predict the severity of disease in diabetic patients with COVID-19. Patients with a score of 7 or higher had an odds ratio of 7.616.Conclusions: Dyspnea is a critical clinical manifestation that is closely related to the severity of disease in diabetic patients with COVID-19. Attention should also be paid to the neutrophil, PLT count and CKMB levels after admission. |
| first_indexed | 2024-12-19T18:08:33Z |
| format | Article |
| id | doaj.art-7de00e7f161848a097b7a92e46fd5a06 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-19T18:08:33Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-7de00e7f161848a097b7a92e46fd5a062022-12-21T20:11:23ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-06-01810.3389/fmed.2021.655604655604Major Characteristics of Severity and Mortality in Diabetic Patients With COVID-19 and Establishment of Severity Risk ScoreYu-Feng Xiao0Jia-Lin He1Jia-Lin He2Jia-Lin He3Yu Xu4Yu Xu5Yu Xu6Xi Liu7Xi Liu8Xi Liu9Hui Lin10Qi Li11Qi Li12Qi Li13Zhi Xu14Zhi Xu15Zhi Xu16Ming-Dong Hu17Ming-Dong Hu18Ming-Dong Hu19Xiao-Bao Ren20Xiao-Bao Ren21Xiao-Bao Ren22Cheng Zhang23Cheng Zhang24Cheng Zhang25Wen-Jing Zhang26Wen-Jing Zhang27Wen-Jing Zhang28Wei Duan29Wei Duan30Wei Duan31Yong-Feng Tian32Yong-Feng Tian33Yong-Feng Tian34Ping Li35Ping Li36Ping Li37Hao Wu38Hao Wu39Cai-Ping Song40Cai-Ping Song41Cai-Ping Song42En Liu43Shi-Ming Yang44Shi-Ming Yang45Shi-Ming Yang46Department of Gastroenterology, Xinqiao Hospital, The Army Medical University, Chongqing, ChinaDepartment of Gastroenterology, Xinqiao Hospital, The Army Medical University, Chongqing, ChinaHuo-Shen-Shan Hospital, Wuhan, ChinaThe Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, ChinaHuo-Shen-Shan Hospital, Wuhan, ChinaThe Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, ChinaDepartment of Respiratory and Critical Care Medicine, Xinqiao Hospital, The Army Medical University, Chongqing, ChinaDepartment of Gastroenterology, Xinqiao Hospital, The Army Medical University, Chongqing, ChinaThe Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, ChinaTaikang Tongji Hospital, Wuhan, ChinaDepartment of Gastroenterology, Xinqiao Hospital, The Army Medical University, Chongqing, ChinaHuo-Shen-Shan Hospital, Wuhan, ChinaThe Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, ChinaDepartment of Respiratory and Critical Care Medicine, Xinqiao Hospital, The Army Medical University, Chongqing, ChinaHuo-Shen-Shan Hospital, Wuhan, ChinaDepartment of Respiratory and Critical Care Medicine, Xinqiao Hospital, The Army Medical University, Chongqing, ChinaTaikang Tongji Hospital, Wuhan, ChinaHuo-Shen-Shan Hospital, Wuhan, ChinaThe Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, ChinaDepartment of Respiratory and Critical Care Medicine, Xinqiao Hospital, The Army Medical University, Chongqing, ChinaHuo-Shen-Shan Hospital, Wuhan, ChinaThe Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, ChinaDepartment of Emergency, Xinan Hospital, The Army Medical University, Chongqing, ChinaHuo-Shen-Shan Hospital, Wuhan, ChinaThe Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, ChinaDepartment of Hematology, Xinqiao Hospital, The Army Medical University, Chongqing, ChinaHuo-Shen-Shan Hospital, Wuhan, ChinaThe Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, ChinaDepartment of Respiratory and Critical Care Medicine, Xinqiao Hospital, The Army Medical University, Chongqing, ChinaHuo-Shen-Shan Hospital, Wuhan, ChinaThe Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, ChinaDepartment of Neurology, Xinqiao Hospital, The Army Medical University, Chongqing, ChinaHuo-Shen-Shan Hospital, Wuhan, ChinaThe Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, ChinaDepartment of Endocrinology, Xinqiao Hospital, The Army Medical University, Chongqing, ChinaHuo-Shen-Shan Hospital, Wuhan, ChinaThe Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, China0Department of Cardiology, Xinqiao Hospital, The Army Medical University, Chongqing, ChinaTaikang Tongji Hospital, Wuhan, China1Xinqiao Hospital, The Army Medical University, Chongqing, ChinaHuo-Shen-Shan Hospital, Wuhan, ChinaThe Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, China1Xinqiao Hospital, The Army Medical University, Chongqing, ChinaDepartment of Gastroenterology, Xinqiao Hospital, The Army Medical University, Chongqing, ChinaDepartment of Gastroenterology, Xinqiao Hospital, The Army Medical University, Chongqing, ChinaHuo-Shen-Shan Hospital, Wuhan, ChinaThe Medical Team of the Army Medical University, Jin-Yin-Tan Hospital, Wuhan, ChinaObjectives: Diabetes is a risk factor for poor COVID-19 prognosis. The analysis of related prognostic factors in diabetic patients with COVID-19 would be helpful for further treatment of such patients.Methods: This retrospective study involved 3623 patients with COVID-19 (325 with diabetes). Clinical characteristics and laboratory tests were collected and compared between the diabetic group and the non-diabetic group. Binary logistic regression analysis was applied to explore risk factors associated in diabetic patients with COVID-19. A prediction model was built based on these risk factors.Results: The risk factors for higher mortality in diabetic patients with COVID-19 were dyspnea, lung disease, cardiovascular diseases, neutrophil, PLT count, and CKMB. Similarly, dyspnea, cardiovascular diseases, neutrophil, PLT count, and CKMB were risk factors related to the severity of diabetes with COVID-19. Based on these factors, a risk score was built to predict the severity of disease in diabetic patients with COVID-19. Patients with a score of 7 or higher had an odds ratio of 7.616.Conclusions: Dyspnea is a critical clinical manifestation that is closely related to the severity of disease in diabetic patients with COVID-19. Attention should also be paid to the neutrophil, PLT count and CKMB levels after admission.https://www.frontiersin.org/articles/10.3389/fmed.2021.655604/fulldiabetesCOVID-19severitymortalityrisk score |
| spellingShingle | Yu-Feng Xiao Jia-Lin He Jia-Lin He Jia-Lin He Yu Xu Yu Xu Yu Xu Xi Liu Xi Liu Xi Liu Hui Lin Qi Li Qi Li Qi Li Zhi Xu Zhi Xu Zhi Xu Ming-Dong Hu Ming-Dong Hu Ming-Dong Hu Xiao-Bao Ren Xiao-Bao Ren Xiao-Bao Ren Cheng Zhang Cheng Zhang Cheng Zhang Wen-Jing Zhang Wen-Jing Zhang Wen-Jing Zhang Wei Duan Wei Duan Wei Duan Yong-Feng Tian Yong-Feng Tian Yong-Feng Tian Ping Li Ping Li Ping Li Hao Wu Hao Wu Cai-Ping Song Cai-Ping Song Cai-Ping Song En Liu Shi-Ming Yang Shi-Ming Yang Shi-Ming Yang Major Characteristics of Severity and Mortality in Diabetic Patients With COVID-19 and Establishment of Severity Risk Score Frontiers in Medicine diabetes COVID-19 severity mortality risk score |
| title | Major Characteristics of Severity and Mortality in Diabetic Patients With COVID-19 and Establishment of Severity Risk Score |
| title_full | Major Characteristics of Severity and Mortality in Diabetic Patients With COVID-19 and Establishment of Severity Risk Score |
| title_fullStr | Major Characteristics of Severity and Mortality in Diabetic Patients With COVID-19 and Establishment of Severity Risk Score |
| title_full_unstemmed | Major Characteristics of Severity and Mortality in Diabetic Patients With COVID-19 and Establishment of Severity Risk Score |
| title_short | Major Characteristics of Severity and Mortality in Diabetic Patients With COVID-19 and Establishment of Severity Risk Score |
| title_sort | major characteristics of severity and mortality in diabetic patients with covid 19 and establishment of severity risk score |
| topic | diabetes COVID-19 severity mortality risk score |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.655604/full |
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