Immunosensing Based on Optical Fiber Technology: Recent Advances
The evolution of optical fiber technology has revolutionized a variety of fields, from optical transmission to environmental monitoring and biomedicine, given their unique properties and versatility. For biosensing purposes, the light guided in the fiber core is exposed to the surrounding media wher...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/11/9/305 |
| _version_ | 1797520050815500288 |
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| author | Maria Simone Soares Miguel Vidal Nuno F. Santos Florinda M. Costa Carlos Marques Sónia O. Pereira Cátia Leitão |
| author_facet | Maria Simone Soares Miguel Vidal Nuno F. Santos Florinda M. Costa Carlos Marques Sónia O. Pereira Cátia Leitão |
| author_sort | Maria Simone Soares |
| collection | DOAJ |
| description | The evolution of optical fiber technology has revolutionized a variety of fields, from optical transmission to environmental monitoring and biomedicine, given their unique properties and versatility. For biosensing purposes, the light guided in the fiber core is exposed to the surrounding media where the analytes of interest are detected by different techniques, according to the optical fiber configuration and biofunctionalization strategy employed. These configurations differ in manufacturing complexity, cost and overall performance. The biofunctionalization strategies can be carried out directly on bare fibers or on coated fibers. The former relies on interactions between the evanescent wave (EW) of the fiber and the analyte of interest, whereas the latter can comprise plasmonic methods such as surface plasmon resonance (SPR) and localized SPR (LSPR), both originating from the interaction between light and metal surface electrons. This review presents the basics of optical fiber immunosensors for a broad audience as well as the more recent research trends on the topic. Several optical fiber configurations used for biosensing applications are highlighted, namely uncladded, U-shape, D-shape, tapered, end-face reflected, fiber gratings and special optical fibers, alongside practical application examples. Furthermore, EW, SPR, LSPR and biofunctionalization strategies, as well as the most recent advances and applications of immunosensors, are also covered. Finally, the main challenges and an outlook over the future direction of the field is presented. |
| first_indexed | 2024-03-10T07:51:22Z |
| format | Article |
| id | doaj.art-7de059664c044f5e97b5131089b70786 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-10T07:51:22Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-7de059664c044f5e97b5131089b707862023-11-22T12:12:21ZengMDPI AGBiosensors2079-63742021-08-0111930510.3390/bios11090305Immunosensing Based on Optical Fiber Technology: Recent AdvancesMaria Simone Soares0Miguel Vidal1Nuno F. Santos2Florinda M. Costa3Carlos Marques4Sónia O. Pereira5Cátia Leitão6Physics Department & I3N, University of Aveiro, 3810-193 Aveiro, PortugalPhysics Department & I3N, University of Aveiro, 3810-193 Aveiro, PortugalPhysics Department & I3N, University of Aveiro, 3810-193 Aveiro, PortugalPhysics Department & I3N, University of Aveiro, 3810-193 Aveiro, PortugalPhysics Department & I3N, University of Aveiro, 3810-193 Aveiro, PortugalPhysics Department & I3N, University of Aveiro, 3810-193 Aveiro, PortugalPhysics Department & I3N, University of Aveiro, 3810-193 Aveiro, PortugalThe evolution of optical fiber technology has revolutionized a variety of fields, from optical transmission to environmental monitoring and biomedicine, given their unique properties and versatility. For biosensing purposes, the light guided in the fiber core is exposed to the surrounding media where the analytes of interest are detected by different techniques, according to the optical fiber configuration and biofunctionalization strategy employed. These configurations differ in manufacturing complexity, cost and overall performance. The biofunctionalization strategies can be carried out directly on bare fibers or on coated fibers. The former relies on interactions between the evanescent wave (EW) of the fiber and the analyte of interest, whereas the latter can comprise plasmonic methods such as surface plasmon resonance (SPR) and localized SPR (LSPR), both originating from the interaction between light and metal surface electrons. This review presents the basics of optical fiber immunosensors for a broad audience as well as the more recent research trends on the topic. Several optical fiber configurations used for biosensing applications are highlighted, namely uncladded, U-shape, D-shape, tapered, end-face reflected, fiber gratings and special optical fibers, alongside practical application examples. Furthermore, EW, SPR, LSPR and biofunctionalization strategies, as well as the most recent advances and applications of immunosensors, are also covered. Finally, the main challenges and an outlook over the future direction of the field is presented.https://www.mdpi.com/2079-6374/11/9/305biosensoroptical fiberbiofunctionalizationsurface plasmon resonance (SPR)antibody |
| spellingShingle | Maria Simone Soares Miguel Vidal Nuno F. Santos Florinda M. Costa Carlos Marques Sónia O. Pereira Cátia Leitão Immunosensing Based on Optical Fiber Technology: Recent Advances Biosensors biosensor optical fiber biofunctionalization surface plasmon resonance (SPR) antibody |
| title | Immunosensing Based on Optical Fiber Technology: Recent Advances |
| title_full | Immunosensing Based on Optical Fiber Technology: Recent Advances |
| title_fullStr | Immunosensing Based on Optical Fiber Technology: Recent Advances |
| title_full_unstemmed | Immunosensing Based on Optical Fiber Technology: Recent Advances |
| title_short | Immunosensing Based on Optical Fiber Technology: Recent Advances |
| title_sort | immunosensing based on optical fiber technology recent advances |
| topic | biosensor optical fiber biofunctionalization surface plasmon resonance (SPR) antibody |
| url | https://www.mdpi.com/2079-6374/11/9/305 |
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