A Hairy Cell Leukaemia Variant – A Rare Case Report
ABSTRACT The aim of the article is to present a rare case of Hairy cell leukaemia variant (HCl-V) which is a distinct clinico-pathological entity with intermediate features between classical HCl (HCl-C) and B-cell prolymphocytic leukaemia. It is an uncommon disorder accounting for approximately...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2013-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/2768/42-%205169_E(C)_PF1(M)_F(P)_PF1(P)_PFA(RP)_OLF_PF1(SPR)_u_(P).pdf |
| Summary: | ABSTRACT
The aim of the article is to present a rare case of Hairy cell leukaemia variant (HCl-V) which is a distinct clinico-pathological entity
with intermediate features between classical HCl (HCl-C) and B-cell
prolymphocytic leukaemia. It is an uncommon disorder accounting
for approximately 0.4% of chronic lymphoid malignancies and 10%
of all HCl cases. A 58 year old woman presented with pain abdomen and loss of weight. On examination she had massive splenomegaly. Peripheral smear was reported as chronic lymphoproliferative disorder (? Hairy cell leukemia or splenic lymphoma with villous
lymphocytes). On Bone marrow examination, differential diagnosis
was given as splenic lymphoma with villous lymphocytes (SLVL)
and prolymphocytic variant of Hairy cell leukemia. On flow cytometric analysis, these cells were positive for CD11c, CD19, CD20,
and CD22. Based on the clinical, peripheral smear, bone marrow
and flow cytometry findings, a diagnosis of hairy cell leukaemia
variant was confirmed. The differential diagnosis should always include SLVL, HCL-C and Japanese variant HCL because they have
different clinical and biological features, particularly regarding their
response to purine analogue-based treatment or splenectomy. |
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| ISSN: | 2249-782X 0973-709X |