Perception of Quality of Life and Fatigue in Multiple Sclerosis Patients Treated with High-Dose Vitamin D
Background: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system, with symptoms that greatly affect quality of life (QoL). One of the most prevalent symptoms of MS is fatigue, also one of the main factors reducing QoL. Low levels of vitamin D (VD) are associated with...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Clinical and Translational Neuroscience |
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| Online Access: | https://www.mdpi.com/2514-183X/7/2/12 |
| _version_ | 1797595332764237824 |
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| author | Antonio Ianniello Andrea Sottosanti Giovanna Borriello Massimo Vincenti |
| author_facet | Antonio Ianniello Andrea Sottosanti Giovanna Borriello Massimo Vincenti |
| author_sort | Antonio Ianniello |
| collection | DOAJ |
| description | Background: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system, with symptoms that greatly affect quality of life (QoL). One of the most prevalent symptoms of MS is fatigue, also one of the main factors reducing QoL. Low levels of vitamin D (VD) are associated with worse QoL and with increased risk of developing more severe forms of the disease. Methods: In this cross-sectional study, we compared perceptions of quality of life and fatigue in 324 patients, subdivided into four groups, according to their treatment: high-dose VD therapy only, disease-modifying therapy (DMT) only, both treatments, and no treatments. All subjects completed the MSQOL-54 and the FSS questionnaires via an online survey. Results: High-dose VD treatment was associated with an increased perception of physical QoL (83.60 vs. 66.92, <i>p</i> < 0.001), mental QoL (75.52 vs. 59.80, <i>p</i> < 0.001), and fatigue (1.89 vs. 2.98, <i>p</i> < 0.001), compared to the DMT-only group. Treatment with DMT was associated with a worse perception of physical QoL compared to no treatment (70.58 vs. 76.53, <i>p</i> = 0.024). Conclusions: high-dose VD treatment is well-tolerated and associated with an increased perception of QoL in people with MS. |
| first_indexed | 2024-03-11T02:35:52Z |
| format | Article |
| id | doaj.art-7de1ce451d4e4cbd8e363a374bddc167 |
| institution | Directory Open Access Journal |
| issn | 2514-183X |
| language | English |
| last_indexed | 2024-03-11T02:35:52Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Clinical and Translational Neuroscience |
| spelling | doaj.art-7de1ce451d4e4cbd8e363a374bddc1672023-11-18T09:57:31ZengMDPI AGClinical and Translational Neuroscience2514-183X2023-04-01721210.3390/ctn7020012Perception of Quality of Life and Fatigue in Multiple Sclerosis Patients Treated with High-Dose Vitamin DAntonio Ianniello0Andrea Sottosanti1Giovanna Borriello2Massimo Vincenti3Department of Human Neurosciences, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Medicine, University of Padova, 35128 Padua, ItalyDepartment of Neurology, San Pietro Fatebenefratelli, 00189 Rome, ItalyAssociazione Italiana Protocollo Coimbra, 35020 Legnaro, ItalyBackground: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system, with symptoms that greatly affect quality of life (QoL). One of the most prevalent symptoms of MS is fatigue, also one of the main factors reducing QoL. Low levels of vitamin D (VD) are associated with worse QoL and with increased risk of developing more severe forms of the disease. Methods: In this cross-sectional study, we compared perceptions of quality of life and fatigue in 324 patients, subdivided into four groups, according to their treatment: high-dose VD therapy only, disease-modifying therapy (DMT) only, both treatments, and no treatments. All subjects completed the MSQOL-54 and the FSS questionnaires via an online survey. Results: High-dose VD treatment was associated with an increased perception of physical QoL (83.60 vs. 66.92, <i>p</i> < 0.001), mental QoL (75.52 vs. 59.80, <i>p</i> < 0.001), and fatigue (1.89 vs. 2.98, <i>p</i> < 0.001), compared to the DMT-only group. Treatment with DMT was associated with a worse perception of physical QoL compared to no treatment (70.58 vs. 76.53, <i>p</i> = 0.024). Conclusions: high-dose VD treatment is well-tolerated and associated with an increased perception of QoL in people with MS.https://www.mdpi.com/2514-183X/7/2/12multiple sclerosisvitamin DCoimbra protocolquality of lifemental healthphysical health |
| spellingShingle | Antonio Ianniello Andrea Sottosanti Giovanna Borriello Massimo Vincenti Perception of Quality of Life and Fatigue in Multiple Sclerosis Patients Treated with High-Dose Vitamin D Clinical and Translational Neuroscience multiple sclerosis vitamin D Coimbra protocol quality of life mental health physical health |
| title | Perception of Quality of Life and Fatigue in Multiple Sclerosis Patients Treated with High-Dose Vitamin D |
| title_full | Perception of Quality of Life and Fatigue in Multiple Sclerosis Patients Treated with High-Dose Vitamin D |
| title_fullStr | Perception of Quality of Life and Fatigue in Multiple Sclerosis Patients Treated with High-Dose Vitamin D |
| title_full_unstemmed | Perception of Quality of Life and Fatigue in Multiple Sclerosis Patients Treated with High-Dose Vitamin D |
| title_short | Perception of Quality of Life and Fatigue in Multiple Sclerosis Patients Treated with High-Dose Vitamin D |
| title_sort | perception of quality of life and fatigue in multiple sclerosis patients treated with high dose vitamin d |
| topic | multiple sclerosis vitamin D Coimbra protocol quality of life mental health physical health |
| url | https://www.mdpi.com/2514-183X/7/2/12 |
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