Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology
Abstract Background This study was conducted to compare the histological diagnostic accuracy of conventional oral-based cytology and liquid-based cytology (LBC) methods. Methods Histological diagnoses of 251 cases were classified as negative (no malignancy lesion, inflammation, or mild/moderate dysp...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-09-01
|
| Series: | Diagnostic Pathology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13000-020-01027-6 |
| _version_ | 1817986617754779648 |
|---|---|
| author | Shintaro Sukegawa Sawako Ono Keisuke Nakano Kiyofumi Takabatake Hotaka Kawai Hitoshi Nagatsuka Yoshihiko Furuki |
| author_facet | Shintaro Sukegawa Sawako Ono Keisuke Nakano Kiyofumi Takabatake Hotaka Kawai Hitoshi Nagatsuka Yoshihiko Furuki |
| author_sort | Shintaro Sukegawa |
| collection | DOAJ |
| description | Abstract Background This study was conducted to compare the histological diagnostic accuracy of conventional oral-based cytology and liquid-based cytology (LBC) methods. Methods Histological diagnoses of 251 cases were classified as negative (no malignancy lesion, inflammation, or mild/moderate dysplasia) and positive [severe dysplasia/carcinoma in situ (CIS) and squamous cell carcinoma (SCC)]. Cytological diagnoses were classified as negative for intraepithelial lesion or malignancy (NILM), oral low-grade squamous intraepithelial lesion (OLSIL), oral high-grade squamous intraepithelial lesion (OHSIL), or SCC. Cytological diagnostic results were compared with histology results. Results Of NILM cytology cases, the most frequent case was negative [LBC n = 50 (90.9%), conventional n = 22 (95.7%)]. Among OLSIL cytodiagnoses, the most common was negative (LBC n = 34; 75.6%, conventional n = 14; 70.0%). Among OHSIL cytodiagnoses (LBC n = 51, conventional n = 23), SCC was the most frequent (LBC n = 31; 60.8%, conventional n = 7; 30.4%). Negative cases were common (LBC n = 13; 25.5%, conventional n = 14; 60.9%). Among SCC cytodiagnoses SCC was the most common (LBC n = 16; 88.9%, conventional n = 14; 87.5%). Regarding the diagnostic results of cytology, assuming OHSIL and SCC as cytologically positive, the LBC method/conventional method showed a sensitivity of 79.4%/76.7%, specificity of 85.1%/69.2%, false-positive rate of 14.9%/30.7%, and false-negative rate of 20.6%/23.3%. Conclusions LBC method was superior to conventional cytodiagnosis methods. It was especially superior for OLSIL and OHSIL. Because of the false-positive and false-negative cytodiagnoses, it is necessary to make a comprehensive diagnosis considering the clinical findings. |
| first_indexed | 2024-04-14T00:11:32Z |
| format | Article |
| id | doaj.art-7de3ba6d501a4981b27c969092f3ad54 |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-04-14T00:11:32Z |
| publishDate | 2020-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-7de3ba6d501a4981b27c969092f3ad542022-12-22T02:23:18ZengBMCDiagnostic Pathology1746-15962020-09-011511610.1186/s13000-020-01027-6Clinical study on primary screening of oral cancer and precancerous lesions by oral cytologyShintaro Sukegawa0Sawako Ono1Keisuke Nakano2Kiyofumi Takabatake3Hotaka Kawai4Hitoshi Nagatsuka5Yoshihiko Furuki6Department of Oral and Maxillofacial Surgery, Kagawa Prefectural Central HospitalDepartment of Pathology, Kagawa Prefectural Central HospitalDepartment of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesDepartment of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesDepartment of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesDepartment of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesDepartment of Oral and Maxillofacial Surgery, Kagawa Prefectural Central HospitalAbstract Background This study was conducted to compare the histological diagnostic accuracy of conventional oral-based cytology and liquid-based cytology (LBC) methods. Methods Histological diagnoses of 251 cases were classified as negative (no malignancy lesion, inflammation, or mild/moderate dysplasia) and positive [severe dysplasia/carcinoma in situ (CIS) and squamous cell carcinoma (SCC)]. Cytological diagnoses were classified as negative for intraepithelial lesion or malignancy (NILM), oral low-grade squamous intraepithelial lesion (OLSIL), oral high-grade squamous intraepithelial lesion (OHSIL), or SCC. Cytological diagnostic results were compared with histology results. Results Of NILM cytology cases, the most frequent case was negative [LBC n = 50 (90.9%), conventional n = 22 (95.7%)]. Among OLSIL cytodiagnoses, the most common was negative (LBC n = 34; 75.6%, conventional n = 14; 70.0%). Among OHSIL cytodiagnoses (LBC n = 51, conventional n = 23), SCC was the most frequent (LBC n = 31; 60.8%, conventional n = 7; 30.4%). Negative cases were common (LBC n = 13; 25.5%, conventional n = 14; 60.9%). Among SCC cytodiagnoses SCC was the most common (LBC n = 16; 88.9%, conventional n = 14; 87.5%). Regarding the diagnostic results of cytology, assuming OHSIL and SCC as cytologically positive, the LBC method/conventional method showed a sensitivity of 79.4%/76.7%, specificity of 85.1%/69.2%, false-positive rate of 14.9%/30.7%, and false-negative rate of 20.6%/23.3%. Conclusions LBC method was superior to conventional cytodiagnosis methods. It was especially superior for OLSIL and OHSIL. Because of the false-positive and false-negative cytodiagnoses, it is necessary to make a comprehensive diagnosis considering the clinical findings.http://link.springer.com/article/10.1186/s13000-020-01027-6CytologyPathologyLiquid-based cytologyScreeningInflammation |
| spellingShingle | Shintaro Sukegawa Sawako Ono Keisuke Nakano Kiyofumi Takabatake Hotaka Kawai Hitoshi Nagatsuka Yoshihiko Furuki Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology Diagnostic Pathology Cytology Pathology Liquid-based cytology Screening Inflammation |
| title | Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology |
| title_full | Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology |
| title_fullStr | Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology |
| title_full_unstemmed | Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology |
| title_short | Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology |
| title_sort | clinical study on primary screening of oral cancer and precancerous lesions by oral cytology |
| topic | Cytology Pathology Liquid-based cytology Screening Inflammation |
| url | http://link.springer.com/article/10.1186/s13000-020-01027-6 |
| work_keys_str_mv | AT shintarosukegawa clinicalstudyonprimaryscreeningoforalcancerandprecancerouslesionsbyoralcytology AT sawakoono clinicalstudyonprimaryscreeningoforalcancerandprecancerouslesionsbyoralcytology AT keisukenakano clinicalstudyonprimaryscreeningoforalcancerandprecancerouslesionsbyoralcytology AT kiyofumitakabatake clinicalstudyonprimaryscreeningoforalcancerandprecancerouslesionsbyoralcytology AT hotakakawai clinicalstudyonprimaryscreeningoforalcancerandprecancerouslesionsbyoralcytology AT hitoshinagatsuka clinicalstudyonprimaryscreeningoforalcancerandprecancerouslesionsbyoralcytology AT yoshihikofuruki clinicalstudyonprimaryscreeningoforalcancerandprecancerouslesionsbyoralcytology |